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Volumn 15, Issue 8, 2009, Pages 857-862

Effects of metabolic approach in diabetic patients with coronary artery disease

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARNITINE PALMITOYLTRANSFERASE I; ENDOTHELIN 1; ETOMOXIR; FATTY ACID; MOXONIDINE; OXFENICINE; PERHEXILINE; TRIMETAZIDINE;

EID: 65649099707     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161209787582093     Document Type: Review
Times cited : (19)

References (59)
  • 1
    • 0034086150 scopus 로고    scopus 로고
    • Relationship between endothelin-1 concentrations and the metabolic alterations typical of the insulin resistance syndrome
    • Piatti PM, Monti LD, Galli L, Fragasso G, Valsecchi G, Conti M, et al. Relationship between endothelin-1 concentrations and the metabolic alterations typical of the insulin resistance syndrome. Metabolism 2000; 49: 748-52.
    • (2000) Metabolism , vol.49 , pp. 748-752
    • Piatti, P.M.1    Monti, L.D.2    Galli, L.3    Fragasso, G.4    Valsecchi, G.5    Conti, M.6
  • 2
    • 17744362283 scopus 로고    scopus 로고
    • Alterations in nitric oxide/cyclic-GMP pathway in nondiabetic siblings of patients with type 2 diabetes
    • Piatti PM, Monti LD, Zavaroni I, Valsecchi G, Van Phan C, Costa S, et al. Alterations in nitric oxide/cyclic-GMP pathway in nondiabetic siblings of patients with type 2 diabetes. J Clin Endocrinol Metab 2000; 85: 2416-20.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2416-2420
    • Piatti, P.M.1    Monti, L.D.2    Zavaroni, I.3    Valsecchi, G.4    Van Phan, C.5    Costa, S.6
  • 3
    • 0033919875 scopus 로고    scopus 로고
    • Role of insulin resistance in heart and skeletal muscle F-18 fluorodeoxyglucose uptake in patients with non-insulin-dependent diabetes mellitus
    • Yokoyama I, Yonekura K, Ohtake T, Kawamura H, Matsumoto A, Inoue Y, et al. Role of insulin resistance in heart and skeletal muscle F-18 fluorodeoxyglucose uptake in patients with non-insulin-dependent diabetes mellitus. J Nucl Cardiol 2000; 7: 242-8.
    • (2000) J Nucl Cardiol , vol.7 , pp. 242-248
    • Yokoyama, I.1    Yonekura, K.2    Ohtake, T.3    Kawamura, H.4    Matsumoto, A.5    Inoue, Y.6
  • 4
    • 0030855598 scopus 로고    scopus 로고
    • Insulin sensitivity, vascular reactivity, and clamp-induced vasodilatation in essential hypertension
    • Natali A, Taddei S, Quiñones Galvan A, Camastra S, Baldi S, Frascerra S, et al. Insulin sensitivity, vascular reactivity, and clamp-induced vasodilatation in essential hypertension. Circulation 1997; 96: 725-6.
    • (1997) Circulation , vol.96 , pp. 725-726
    • Natali, A.1    Taddei, S.2    Quiñones Galvan, A.3    Camastra, S.4    Baldi, S.5    Frascerra, S.6
  • 6
    • 0038681950 scopus 로고    scopus 로고
    • The Relationship between insulin resistance and polymorphisms of the endothelial nitric oxide synthase gene in patients with coronary artery disease
    • Yoshimura T, Hisatomi A, Kajihara S, Yasutake T, Ogawa Y, Mizuta T, et al. The Relationship between insulin resistance and polymorphisms of the endothelial nitric oxide synthase gene in patients with coronary artery disease. J Atheroscler Thromb 2003; 10: 43-7.
    • (2003) J Atheroscler Thromb , vol.10 , pp. 43-47
    • Yoshimura, T.1    Hisatomi, A.2    Kajihara, S.3    Yasutake, T.4    Ogawa, Y.5    Mizuta, T.6
  • 7
    • 0033230056 scopus 로고    scopus 로고
    • Endothelial and metabolic characteristics of patients with angina and angiographically normal coronary arteries
    • Piatti PM, Fragasso G, Monti LD, Caumo A, Phan VC, Valsecchi G, et al. Endothelial and metabolic characteristics of patients with angina and angiographically normal coronary arteries. J Am Coll Cardiol 1999; 34: 1452-60.
    • (1999) J Am Coll Cardiol , vol.34 , pp. 1452-1460
    • Piatti, P.M.1    Fragasso, G.2    Monti, L.D.3    Caumo, A.4    Phan, V.C.5    Valsecchi, G.6
  • 9
    • 0242381316 scopus 로고    scopus 로고
    • Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting
    • Piatti P, Di Mario C, Monti LD, Fragasso G, Sgura F, Caumo A, et al. Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting. Circulation 2003; 108: 2074-81.
    • (2003) Circulation , vol.108 , pp. 2074-2081
    • Piatti, P.1    Di Mario, C.2    Monti, L.D.3    Fragasso, G.4    Sgura, F.5    Caumo, A.6
  • 10
    • 0033592101 scopus 로고    scopus 로고
    • Glucose tolerance and mortality: Comparison of WHO and American Diabetes Association diagnostic criteria
    • The Decode Study Group
    • The Decode Study Group. Glucose tolerance and mortality: Comparison of WHO and American Diabetes Association diagnostic criteria. Lancet 1999; 354: 617-21
    • (1999) Lancet , vol.354 , pp. 617-621
  • 12
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 2002; 23: 201-29.
    • (2002) Endocr Rev , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 13
    • 0035985081 scopus 로고    scopus 로고
    • Vascular function, insulin resistance and fatty acids
    • Steinberg HO, Baron AD. Vascular function, insulin resistance and fatty acids. Diabetologia 2002; 45: 623-34.
    • (2002) Diabetologia , vol.45 , pp. 623-634
    • Steinberg, H.O.1    Baron, A.D.2
  • 15
    • 53149138585 scopus 로고    scopus 로고
    • Deleterious action of FA metabolites on ATP synthesis: Possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance
    • Abdul-Ghani MA, Muller FL, Liu Y, Chavez AO, Balas B, Zuo P, et al. Deleterious action of FA metabolites on ATP synthesis: Possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. Am J Physiol Endocrinol Metab. 2008; 295: E678-85.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Abdul-Ghani, M.A.1    Muller, F.L.2    Liu, Y.3    Chavez, A.O.4    Balas, B.5    Zuo, P.6
  • 16
    • 0035933194 scopus 로고    scopus 로고
    • Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure
    • Wallhaus TR, Taylor M, DeGrado TR, Russell DC. Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure. Circulation 2001; 103: 2441-6.
    • (2001) Circulation , vol.103 , pp. 2441-2446
    • Wallhaus, T.R.1    Taylor, M.2    DeGrado, T.R.3    Russell, D.C.4
  • 17
    • 0036932990 scopus 로고    scopus 로고
    • Effect of selective and nonselective beta-blockers on resting energy production rate and total body substrate utilization in chronic heart failure
    • Podbregar M, Voga G. Effect of selective and nonselective beta-blockers on resting energy production rate and total body substrate utilization in chronic heart failure. J Cardiac Fail 2002: 8: 369-378.
    • (2002) J Cardiac Fail , vol.8 , pp. 369-378
    • Podbregar, M.1    Voga, G.2
  • 19
    • 3142776467 scopus 로고    scopus 로고
    • Carvedilol Or Metoprolol European Trial Investigators. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET): Randomised controlled trial
    • Poole-Wilson P, Swedberg K, Cleland J, Di Lenarda A, Hanrath P, Komajda M, et al. Carvedilol Or Metoprolol European Trial Investigators. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET): Randomised controlled trial. Lancet 2003; 362: 7-13.
    • (2003) Lancet , vol.362 , pp. 7-13
    • Poole-Wilson, P.1    Swedberg, K.2    Cleland, J.3    Di Lenarda, A.4    Hanrath, P.5    Komajda, M.6
  • 20
    • 0346730904 scopus 로고    scopus 로고
    • Wiltse C, Wright T; for the MOXCON Investigators. Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON). Eur J Heart Fail 2003; 5: 659-66
    • Wiltse C, Wright T; for the MOXCON Investigators. Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON). Eur J Heart Fail 2003; 5: 659-66
  • 21
    • 33644760351 scopus 로고    scopus 로고
    • Mobini R, Jansson PA, Bergh CH, Sharing Tang M, Waagstein F, Andersson B. Influence of central inhibition of sympathetic nervous activity on myocardial metabolism in chronic heart failure: Acute effects of the imidazoline I1-receptor agonist moxonidine. Clin Sci 2006; 110: 329-36.
    • Mobini R, Jansson PA, Bergh CH, Sharing Tang M, Waagstein F, Andersson B. Influence of central inhibition of sympathetic nervous activity on myocardial metabolism in chronic heart failure: Acute effects of the imidazoline I1-receptor agonist moxonidine. Clin Sci 2006; 110: 329-36.
  • 22
    • 50949089151 scopus 로고    scopus 로고
    • Heart rate reduction is probably not the main beneficial mechanism by which beta blockade improves outcome in patients with systolic chronic heart failure
    • Fragasso G, Salerno A, Margonato A. Heart rate reduction is probably not the main beneficial mechanism by which beta blockade improves outcome in patients with systolic chronic heart failure. Am J Cardiol 2008; 102: 506-7.
    • (2008) Am J Cardiol , vol.102 , pp. 506-507
    • Fragasso, G.1    Salerno, A.2    Margonato, A.3
  • 23
    • 0027724432 scopus 로고
    • Metabolic management of ischaemic heart disease
    • Chierchia S, Fragasso G: Metabolic management of ischaemic heart disease. Eur Heart J 1993; 14(Suppl G): 2-5.
    • (1993) Eur Heart J , vol.14 , Issue.SUPPL. G , pp. 2-5
    • Chierchia, S.1    Fragasso, G.2
  • 24
    • 33744994173 scopus 로고    scopus 로고
    • Improved myocardial high-energy phosphate metabolism induced by partial fatty acid inhibition in patients with heart failure
    • Fragasso G, De Cobelli F, Perseghin G, Esposito A, Palloshi A, Bassanelli G, et al. Improved myocardial high-energy phosphate metabolism induced by partial fatty acid inhibition in patients with heart failure. J Am Coll Cardiol 2004; 43: 190A.
    • (2004) J Am Coll Cardiol , vol.43
    • Fragasso, G.1    De Cobelli, F.2    Perseghin, G.3    Esposito, A.4    Palloshi, A.5    Bassanelli, G.6
  • 26
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial longchain 3-ketoacyl coenzyme A thiolase
    • Kantor PF, Lucien A, Kozak R, Lopaschuk GD. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial longchain 3-ketoacyl coenzyme A thiolase. Circ Res 2000; 86: 580-8.
    • (2000) Circ Res , vol.86 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 27
    • 0025307724 scopus 로고
    • Therapeutic value of a cardioprotective agent in patients with severe ischemic cardiomyopathy
    • Brottier L, Barat JL, Combe C, Boussens B, Bonnet J, Bricaud H. Therapeutic value of a cardioprotective agent in patients with severe ischemic cardiomyopathy. Eur Heart J 1990; 11: 207-12.
    • (1990) Eur Heart J , vol.11 , pp. 207-212
    • Brottier, L.1    Barat, J.L.2    Combe, C.3    Boussens, B.4    Bonnet, J.5    Bricaud, H.6
  • 28
    • 0032189888 scopus 로고    scopus 로고
    • Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease
    • Lu C, Dabrowski P, Fragasso G, Chierchia SL. Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease. Am J Cardiol 1998; 82: 898-901
    • (1998) Am J Cardiol , vol.82 , pp. 898-901
    • Lu, C.1    Dabrowski, P.2    Fragasso, G.3    Chierchia, S.L.4
  • 29
    • 12744278944 scopus 로고    scopus 로고
    • Short and long term beneficial effects of partial free fatty acid inhibition in diabetic patients with ischemic dilated cardiomyopathy
    • Fragasso G, Piatti PM, Monti L, Palloshi A, Setola E, Puccetti P, et al. Short and long term beneficial effects of partial free fatty acid inhibition in diabetic patients with ischemic dilated cardiomyopathy. Am Heart J 2003; 146: E1-8.
    • (2003) Am Heart J , vol.146
    • Fragasso, G.1    Piatti, P.M.2    Monti, L.3    Palloshi, A.4    Setola, E.5    Puccetti, P.6
  • 30
    • 2942512039 scopus 로고    scopus 로고
    • Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: A double-blind placebo-controlled study
    • Rosano GMC, Vitale C, Sposato B, Mercuro G, Fini M. Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: A double-blind placebo-controlled study. Cardiovasc Diabetol 2003; 2: 16/1-16/9.
    • Cardiovasc Diabetol 2003; 2: 16/1-16/9
    • Rosano, G.M.C.1    Vitale, C.2    Sposato, B.3    Mercuro, G.4    Fini, M.5
  • 32
    • 0029792760 scopus 로고    scopus 로고
    • Effects of insulin treatment on cause-specific one-year mortality and morbidity in diabetic patients with acute myocardial infarction. DIGAMI study group
    • Malmberg K, Ryden L, Hamsten A, Herlitz J, Waldenström A, Wedel H. Effects of insulin treatment on cause-specific one-year mortality and morbidity in diabetic patients with acute myocardial infarction. DIGAMI study group, Eur Heart J 1996; 17: 1337-44.
    • (1996) Eur Heart J , vol.17 , pp. 1337-1344
    • Malmberg, K.1    Ryden, L.2    Hamsten, A.3    Herlitz, J.4    Waldenström, A.5    Wedel, H.6
  • 33
    • 0032564373 scopus 로고    scopus 로고
    • Metabolic modulation of acute myocardial infarction. The ECLA glucose- insulin-potassium pilot trial
    • Diaz R, Paolasso EC, Piegas LS, Tajer CD, Moreno MG, Corvalán R, et al. Metabolic modulation of acute myocardial infarction. The ECLA glucose- insulin-potassium pilot trial. Circulation 1998; 98: 2227-34
    • (1998) Circulation , vol.98 , pp. 2227-2234
    • Diaz, R.1    Paolasso, E.C.2    Piegas, L.S.3    Tajer, C.D.4    Moreno, M.G.5    Corvalán, R.6
  • 34
    • 0030861078 scopus 로고    scopus 로고
    • Glucose-insulin-potassium (GIK) therapy for treatment of acute myocardial infarction: An overview of randomized placebo controlled trials
    • Fath-Ordoubadi F, Beatt KJ. Glucose-insulin-potassium (GIK) therapy for treatment of acute myocardial infarction: An overview of randomized placebo controlled trials. Circulation 1997; 96: 1152-6
    • (1997) Circulation , vol.96 , pp. 1152-1156
    • Fath-Ordoubadi, F.1    Beatt, K.J.2
  • 35
    • 0037028648 scopus 로고    scopus 로고
    • Acute effects of heparin administration on the ischemic threshold of patients with coronary artery disease: Evaluation of the protective role of the metabolic modulator trimetazidine
    • Fragasso G, Piatti P, Monti L, Palloshi A, Lu C, Valsecchi G, et al. Acute effects of heparin administration on the ischemic threshold of patients with coronary artery disease: Evaluation of the protective role of the metabolic modulator trimetazidine. J Am Coll Cardiol 2002; 39: 413-9.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 413-419
    • Fragasso, G.1    Piatti, P.2    Monti, L.3    Palloshi, A.4    Lu, C.5    Valsecchi, G.6
  • 36
    • 0033609032 scopus 로고    scopus 로고
    • Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters: Increase in endothelin production in the heart and beneficial effect of endothelin A antagonist on survival and cardiac function
    • Yamauchi-Kohno R, Miyauchi T, Hoshino T, Kobayashi T, Aihara H, Sakai S, et al. Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters: Increase in endothelin production in the heart and beneficial effect of endothelin A antagonist on survival and cardiac function. Circulation 1999; 99: 2171-6.
    • (1999) Circulation , vol.99 , pp. 2171-2176
    • Yamauchi-Kohno, R.1    Miyauchi, T.2    Hoshino, T.3    Kobayashi, T.4    Aihara, H.5    Sakai, S.6
  • 37
    • 0021961392 scopus 로고
    • Effects of trimetazidine on membrane damage induced by oxygen free radicals in human red cells
    • Maridonneau-Parini I, Harpey C. Effects of trimetazidine on membrane damage induced by oxygen free radicals in human red cells. Br J Clin Pharmacol 1985; 20: 148-151.
    • (1985) Br J Clin Pharmacol , vol.20 , pp. 148-151
    • Maridonneau-Parini, I.1    Harpey, C.2
  • 38
    • 2142641791 scopus 로고    scopus 로고
    • Trimetazidine diminishes fasting glucose in rats with fasting hyperglycemia: A preliminary study
    • Cano C, Bermúdez VJ, Medina MT, Bermúdez FA, Ambard MJ, Souki AJ, et al. Trimetazidine diminishes fasting glucose in rats with fasting hyperglycemia: A preliminary study. Am J Ther 2003; 10: 444-6.
    • (2003) Am J Ther , vol.10 , pp. 444-446
    • Cano, C.1    Bermúdez, V.J.2    Medina, M.T.3    Bermúdez, F.A.4    Ambard, M.J.5    Souki, A.J.6
  • 39
    • 33644878025 scopus 로고    scopus 로고
    • Metabolic and Endothelial Effects of Trimetazidine on Forearm Muscle in Patients with Type 2 Diabetes and Ischemic Cardiomyopathy
    • Monti LD, Setola E, Fragasso G, Camisasca RP, Lucotti P, Galluccio E, et al. Metabolic and Endothelial Effects of Trimetazidine on Forearm Muscle in Patients with Type 2 Diabetes and Ischemic Cardiomyopathy. Am J Physiol Endocrinol Metab 2006; 290: E54-9.
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Monti, L.D.1    Setola, E.2    Fragasso, G.3    Camisasca, R.P.4    Lucotti, P.5    Galluccio, E.6
  • 40
    • 33744981111 scopus 로고    scopus 로고
    • Fragasso G, Montano C, Perseghin G, Palloshi A, Calori G, Lattuada G, et al. The antiischaemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition. Am Heart J 2006; 151: 1238.e1-1238.e8.
    • Fragasso G, Montano C, Perseghin G, Palloshi A, Calori G, Lattuada G, et al. The antiischaemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition. Am Heart J 2006; 151: 1238.e1-1238.e8.
  • 41
    • 0024262853 scopus 로고    scopus 로고
    • Lopashuck GD, Wall SR, Olley PM, Davies NJ. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res 1988; 63: 1036-43.
    • Lopashuck GD, Wall SR, Olley PM, Davies NJ. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res 1988; 63: 1036-43.
  • 42
    • 0025991923 scopus 로고
    • Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus
    • Ratheiser K, Schneeweiss B, Waldhausl W, Fasching P, Korn A, Nowotny P, et al. Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus. Metabolism 1991; 40: 1185-9062.
    • (1991) Metabolism , vol.40 , pp. 1185-9062
    • Ratheiser, K.1    Schneeweiss, B.2    Waldhausl, W.3    Fasching, P.4    Korn, A.5    Nowotny, P.6
  • 43
    • 0030778603 scopus 로고    scopus 로고
    • Etomoxir improves left ventricular performance of pressure-overloaded rat heart
    • Turcani M, Rupp H. Etomoxir improves left ventricular performance of pressure-overloaded rat heart. Circulation 1997; 96: 3681-6
    • (1997) Circulation , vol.96 , pp. 3681-3686
    • Turcani, M.1    Rupp, H.2
  • 44
    • 0036195453 scopus 로고    scopus 로고
    • Therapeutic potential of CPT I inhibitors: Cardiac gene transcription as a target
    • Zarain-Herzberg A, Rupp H. Therapeutic potential of CPT I inhibitors: cardiac gene transcription as a target. Expert Opin Investig Drugs 2002; 11: 345-56
    • (2002) Expert Opin Investig Drugs , vol.11 , pp. 345-356
    • Zarain-Herzberg, A.1    Rupp, H.2
  • 45
    • 0033910352 scopus 로고    scopus 로고
    • First clinical trial with etomoxir in patients with chronic congestive heart failure
    • Schmidt-Schweda S, Holubarsch C. First clinical trial with etomoxir in patients with chronic congestive heart failure. Clin Sci 2000; 99: 27-35
    • (2000) Clin Sci , vol.99 , pp. 27-35
    • Schmidt-Schweda, S.1    Holubarsch, C.2
  • 46
    • 0029587279 scopus 로고
    • Improvement of myocardial function and metabolism in diabetic rats by the carnitine palmitoyl transferase inhibitor etomoxir
    • Schmitz FJ, Rösen P, Reinauer H. Improvement of myocardial function and metabolism in diabetic rats by the carnitine palmitoyl transferase inhibitor etomoxir. Horm Metab Res 1995; 27: 515-22
    • (1995) Horm Metab Res , vol.27 , pp. 515-522
    • Schmitz, F.J.1    Rösen, P.2    Reinauer, H.3
  • 47
    • 0142060197 scopus 로고    scopus 로고
    • Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy
    • Cabreros A, Merlos M, Laguna JC, Carrera MV. Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy. J Lipid Res 2003; 44: 388-98.
    • (2003) J Lipid Res , vol.44 , pp. 388-398
    • Cabreros, A.1    Merlos, M.2    Laguna, J.C.3    Carrera, M.V.4
  • 48
    • 0035996062 scopus 로고    scopus 로고
    • Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically
    • Merril CL, Ni H, Yoon LW, Yoon LW, Tirmenstein MA, Narayanan P, et al. Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically. Toxicol Sci 2002; 68: 93-101.
    • (2002) Toxicol Sci , vol.68 , pp. 93-101
    • Merril, C.L.1    Ni, H.2    Yoon, L.W.3    Yoon, L.W.4    Tirmenstein, M.A.5    Narayanan, P.6
  • 49
    • 0033653158 scopus 로고    scopus 로고
    • Effect of perhexilline and oxfenicine on myocardial function and metabolism during low flow ischemia/reperfusion in the isolated rat heart
    • Kennedy JA, Kiosoglus AJ, Murphy GA, Pelle MA, Horowitz JD. Effect of perhexilline and oxfenicine on myocardial function and metabolism during low flow ischemia/reperfusion in the isolated rat heart. J Cardiovasc Pharmacol 2000; 36: 794-801
    • (2000) J Cardiovasc Pharmacol , vol.36 , pp. 794-801
    • Kennedy, J.A.1    Kiosoglus, A.J.2    Murphy, G.A.3    Pelle, M.A.4    Horowitz, J.D.5
  • 50
    • 0028953680 scopus 로고
    • Direct evidence that perhexiline modifies myocardial substrate utilization from fatty acids to lactate
    • Jeffrey FM, Alvarez L, Diczku V, Sherry AD, Mallory CR. Direct evidence that perhexiline modifies myocardial substrate utilization from fatty acids to lactate. J Cardiovasc Pharmacol 1995; 25: 469-72
    • (1995) J Cardiovasc Pharmacol , vol.25 , pp. 469-472
    • Jeffrey, F.M.1    Alvarez, L.2    Diczku, V.3    Sherry, A.D.4    Mallory, C.R.5
  • 51
    • 0021864482 scopus 로고
    • Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine
    • Stephens TW, Higgins AJ, Cook GA, Harris RA. Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine. Biochem J 1985; 227: 651-60
    • (1985) Biochem J , vol.227 , pp. 651-660
    • Stephens, T.W.1    Higgins, A.J.2    Cook, G.A.3    Harris, R.A.4
  • 52
    • 0019122736 scopus 로고
    • Beneficial effect of enhanced myocardial carbohydrate utilisation after oxfenicine (L-hydroxyphenylglycine) in angina pectoris
    • Bergman G, Atkinson L, Metcalfe J, Jackson J, Jewitt DE. Beneficial effect of enhanced myocardial carbohydrate utilisation after oxfenicine (L-hydroxyphenylglycine) in angina pectoris. Eur Heart J 1980; 1: 247-53.
    • (1980) Eur Heart J , vol.1 , pp. 247-253
    • Bergman, G.1    Atkinson, L.2    Metcalfe, J.3    Jackson, J.4    Jewitt, D.E.5
  • 53
    • 0025343177 scopus 로고
    • Efficacy and safety of perhexiline maleate in refractory angina: A double-blind placebo-controlled clinical trial of a novel antianginal agent
    • Cole PL, Beamer AD, McGowan N, Cantillon CO, Benfell K, Kelly RA, et al. Efficacy and safety of perhexiline maleate in refractory angina: a double-blind placebo-controlled clinical trial of a novel antianginal agent. Circulation 1990; 81: 1260-70.
    • (1990) Circulation , vol.81 , pp. 1260-1270
    • Cole, P.L.1    Beamer, A.D.2    McGowan, N.3    Cantillon, C.O.4    Benfell, K.5    Kelly, R.A.6
  • 54
    • 33644875657 scopus 로고    scopus 로고
    • Metabolic modulation with perhexiline in chronic heart failure. A randomized, controlled trial of short-term use of a novel treatment
    • Lee L, Campbell R, Scheuermann-Freestone M, Taylor R, Gunaruwan P, Williams L, et al. Metabolic modulation with perhexiline in chronic heart failure. A randomized, controlled trial of short-term use of a novel treatment. Circulation 2005; 112: 3280-8.
    • (2005) Circulation , vol.112 , pp. 3280-3288
    • Lee, L.1    Campbell, R.2    Scheuermann-Freestone, M.3    Taylor, R.4    Gunaruwan, P.5    Williams, L.6
  • 55
    • 0022508927 scopus 로고
    • Perhexiline-induced lipidosis in the dark Agouti (DA) rat: An animal model of genetically determined neurotoxicity
    • Meier C, Wahllaender A, Hess CW, Preisig R. Perhexiline-induced lipidosis in the dark Agouti (DA) rat: An animal model of genetically determined neurotoxicity. Brain 1986; 109: 649-660.
    • (1986) Brain , vol.109 , pp. 649-660
    • Meier, C.1    Wahllaender, A.2    Hess, C.W.3    Preisig, R.4
  • 56
    • 0007619884 scopus 로고    scopus 로고
    • Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease
    • Killalea SM, Krum H. Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease. Am J Cardiovasc Drugs 2001; 1: 193-204.
    • (2001) Am J Cardiovasc Drugs , vol.1 , pp. 193-204
    • Killalea, S.M.1    Krum, H.2
  • 57
    • 53549109135 scopus 로고    scopus 로고
    • How do the Australian guidelines for lipid-lowering drugs perform in practice? Cardiovascular disease risk in the Aus-Diab Study 1999-2000
    • Chen L, Rogers SL, Colagiuri S, Cadilhac DA, Mathew TH, Boyden AN, et al. How do the Australian guidelines for lipid-lowering drugs perform in practice? Cardiovascular disease risk in the Aus-Diab Study 1999-2000. Med J Aust 2008; 189(6): 319-322.
    • (2008) Med J Aust , vol.189 , Issue.6 , pp. 319-322
    • Chen, L.1    Rogers, S.L.2    Colagiuri, S.3    Cadilhac, D.A.4    Mathew, T.H.5    Boyden, A.N.6
  • 58
    • 44349168867 scopus 로고    scopus 로고
    • Fatty acid synthesis in protozoan parasites: Unusual pathways and novel drug targets
    • Goodman CD, McFadden GI. Fatty acid synthesis in protozoan parasites: unusual pathways and novel drug targets. Curr Pharm Des 2008; 14(9): 901-16.
    • (2008) Curr Pharm Des , vol.14 , Issue.9 , pp. 901-916
    • Goodman, C.D.1    McFadden, G.I.2
  • 59
    • 44449125709 scopus 로고    scopus 로고
    • The role of AGEs in cardiovascular disease
    • Jandeleit-Dahm K, Cooper ME. The role of AGEs in cardiovascular disease. Curr Pharm Des 2008; 14(10): 979-86.
    • (2008) Curr Pharm Des , vol.14 , Issue.10 , pp. 979-986
    • Jandeleit-Dahm, K.1    Cooper, M.E.2


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