Acute effects of heparin administration on the ischemic threshold of patients with coronary artery disease: Evaluation of the protective role of the metabolic modulator trimetazidine

Journal of the American College of Cardiology

Volumn 39, Issue 3, 2002, Pages 413-419

  Fragasso, Gabriele ^a,b   Piatti, Pier Marco ^a   Monti, Lucilla ^a   Palloshi, Altin ^a   Lu, Chunzeng ^a   Valsecchi, Gianpietro ^a   Setola, Emanuela ^a   Calori, Giliola ^a   Pozza, Guido ^a   Margonato, Alberto ^a   Chierchia, Sergio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; FATTY ACID; GLUCOSE; HEPARIN; NITRIC OXIDE; PLACEBO; TRIMETAZIDINE;

ADULT; AGED; ARTICLE; BOLUS INJECTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOUBLE BLIND PROCEDURE; ENERGY YIELD; EXERCISE; FATTY ACID OXIDATION; GLUCOSE METABOLISM; GLUCOSE OXIDATION; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HUMAN; ISCHEMIC HEART DISEASE; MALE; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT DEPRESSION; TREADMILL EXERCISE;

EID: 0037028648     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(01)01768-5     Document Type: Article

References (51)

1. Lipolysis in plasma after subcutaneous, intramuscular and intravenous heparin in small doses
2. Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium swine
3. Effects of low dose heparin infusion on arterial endothelin-1 release in man
4. High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells
5. Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor
6. High-dose heparin impairs nitric oxide pathway and vasomotion in rats
7. Detrimental effects of high dose heparin administration on ischemic threshold in patients with coronary artery disease
8. Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragment
9. Plasma lipolytic activity and substrate oxidation after subcutaneous administration of heparin and a low molecular weight heparin fragment
10. Protective effects of trimetazidine on ischemic myocardial dysfunction
11. 31P-NMR spectroscopy in the isolated rat heart
12. 1 in the rat isolated ventricular myocyte
13. 2+ regulation by trimetazidine during cardiac cell acidosis
14. Effects of trimetazidine on membrane damage induced by oxygen free radicals in human red cells
15. Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation
16. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
17. Efficacy of trimetazidine in stable effort angina: Double-blind study against placebo
18. Acute effects of trimetazidine evaluated by exercise testing
19. Beneficial effects of trimetazidine in men with stable angina under beta-blocker treatment
20. Comparison of trimetazidine with nifedipine in effort angina: A double-blind, crossover study
21. Trimetazidine: Comparison with propranolol in patients with stable angina
22. Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease: A double-blind, placebo-controlled, crossover study
23. + when the Griess reaction is used to assay for nitrite
24. Hypertriglyceridemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans
25. Fluorimetric method for the measurement of intermediate metabolites (lactate, pyruvate, alanine, beta-hydroxybutyrate, glycerol) using a Cobas Fara centrifugal analyzer
26. Alteration of carbohydrate and lipid metabolism in the acutely ischemic heart
27. Paradoxical role of lipid metabolism in heart function and dysfunction
28. Effects of ranolazine on ischemic threshold, coronary sinus blood flow, and myocardial metabolism in coronary artery disease
29. Effects of glucose and fatty acids on myocardial ischemia and arrhythmias
30. Metabolic support for the post-ischemic heart
31. Regulation of fatty acid oxidation in the mammalian heart in health and disease
32. Metabolic management of ischemic heart disease
33. Glucose, insulin, potassium in acute myocardial infarction
34. Effect of myocardial ischemia and antilipolytic agents on lipolysis and fatty acid metabolism in the in situ dog heart
35. Beta-adrenergic blockade: Hemodynamics and myocardial energy metabolism in patients with ischemic heart disease
36. Effects of propranolol on the hemodynamic, coronary sinus blood flow and myocardial metabolic response to atrial pacing
37. Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia
38. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts
39. The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia
40. Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts
41. Effects of trimetazidine on metabolic and functional recoverv of post-ischemic rat hearts
42. Trimetazidine-induced enhancement of myocardial glucose utilization in normal and ischemic myocardial tissue: An evaluation by positron emission tomography
43. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation
44. Metabolism of exogenous substrates by coronary endothelial cells in culture
45. The pH-partition profile of the anti-ischemic drug trimetazidine may explain its reduction of intracellular acidosis
46. 125I-labeled endothelin-1 binding in rat cardiac membranes
47. Increased in-vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia
48. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
49. Immunoreactive endothelin in human plasma: Marked alterations in cardiogenic shock
50. Endothelin release: A marker for the severity of exercise-induced myocardial ischemia
51. Triglycerides impair post-ischemic recovery in isolated hearts: Roles of endothelin-1 and trimetazidine