The anti-ischemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition

American Heart Journal

Volumn 151, Issue 6, 2006, Pages 1238.e1-1238.e8

  Fragasso, Gabriele ^a   Montano, Chiara ^a   Perseghin, Gianluca ^a   Palloshi, Altin ^a   Calori, Giliola ^a   Lattuada, Guido ^a   Oggionni, Silvia ^a   Bassanelli, Giorgio ^a   Locatelli, Massimo ^a   Lopaschuk, Gary ^b   Margonato, Alberto ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CONTRAST MEDIUM; FATTY ACID; NITRATE; PLACEBO; TRIMETAZIDINE;

ADULT; AGED; ARTICLE; CARBOHYDRATE DIET; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ECHOCARDIOGRAPHY; EVALUATION; FEMALE; FOOD COMPOSITION; FOOD INTAKE; HEART ATRIUM FIBRILLATION; HEART LEFT VENTRICLE FUNCTION; HEART MOVEMENT; HEART MUSCLE ISCHEMIA; HUMAN; LIPID DIET; MALE; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; ST SEGMENT DEPRESSION; STRESS ECHOCARDIOGRAPHY; TREADMILL EXERCISE; TREATMENT OUTCOME;

EID: 33744981111     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2006.01.006     Document Type: Article

References (40)

1. Heberden W. Some account of a disorder of the breast. Med Trans (College of Physicians in London) 2 (1772) 59-67
2. Kelbaek H., Munck O., Christense N.J., et al. Central haemodynamic changes after a meal. Br Heart J 61 (1989) 506-509
3. Muller A.F., Fullwood L., Hawkins M., et al. The integrated response of the cardiovascular system to food. Digestion 52 (1992) 184-193
4. Kearney M.T., Charlesworth A., Cowley A.J., et al. William Heberden revisited: postprandial angina-interval between food and exercise and meal composition are important determinants of time to onset of ischemia and maximal exercise tolerance. J Am Coll Cardiol 29 (1997) 302-307
5. Baliga R.R., Burden L., Sidhu M.K., et al. Effects of components of meals (carbohydrate, fat, protein) in causing postprandial exertional angina pectoris. Am J Cardiol 79 (1997) 1397-1400
6. Lam F.Y., Wilson A.T., and Channer K.S. The effect of meals of differing composition on exercise tolerance in patients with angina pectoris. Eur Heart J 17 (1996) 394-398
7. Edwards C., Stewart R.A.H., Ramanathan K., et al. Increased myocardial ischemia after food is not explained by endothelial dysfunction. Am Heart J 144 (2002) e8
8. Dalla-Volta S., Maraglino G., Della-Valentina P., et al. Comparison of trimetazidine with nifedipine in effort angina: a double blind, cross-over study. Cardiovasc Drugs Ther 4 (1990) 853-860
9. 31P-NMR spectroscopy in the isolated rat heart. Arch Int Pharmacodyn Ther 286 (1987) 97-110
10. Fragasso G., De Cobelli F., Perseghin G., et al. Improved myocardial high-energy phosphate metabolism induced by partial fatty acid inhibition in patients with heart failure. J Am Coll Cardiol 43 (2004) 190A
11. 2+ regulation by trimetazidine during cardiac cell acidosis. Cardiovasc Drugs Ther 1 (1988) 677-686
12. Maridonneau-Parini I., and Harpey C. Effects of trimetazidine on membrane damage induced by oxygen free radicals in human red cells. Br J Clin Pharmacol 20 (1985) 148-151
13. Boucher F.R., Hearse D.J., and Opie L.H. Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts. J Cardiovasc Pharmacol 24 (1994) 45-49
14. Aussedat J., Ray A., Kay L., et al. Improvement of long term preservation of the isolated arrested rat heart: beneficial effect of the antiischemic agent trimetazidine. J Cardiovasc Pharmacol 21 (1993) 128-135
15. Allibardi S., Chierchia S.L., Margonato V., et al. Effects of trimetazidine on metabolic and functional recovery of postischemic rat hearts. Cardiovasc Drugs Ther 12 (1998) 543-549
16. Brottier L., Barat J.L., Combe C., et al. Therapeutic value of a cardioprotective agent in patients with severe ischemic cardiomyopathy. Eur Heart J 11 (1990) 207-212
17. Lu C., Dabrowski P., Fragasso G., et al. Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease: a double-blind, placebo-controlled, crossover study. Am J Cardiol 82 (1998) 898-901
18. Fragasso G., Piatti P.M., Monti L., et al. Short and long term beneficial effects of partial free fatty acid inhibition in diabetic patients with ischemic dilated cardiomyopathy. Am Heart J 146 (2003) E1-E8
19. Lattuada G., Piceni Sereni L., et al. Postabsorptive and insulin-stimulated energy homeostasis and leucine turnover in offspring of T2DM patients. Diabetes Care 27 (2004) 2716-2722
20. Ciapponi A., Pizarro R., and Harrison J. Trimetazidine for stable angina. Cochrane Database Syst Rev 4 (2005) CD 003614
21. Ceriello A., Taboga C., Tonutti L., et al. Evidence for an independent and cumulative effect of postprandial hyperglycemia on endothelial dysfunction and oxidative stress generation. Circulation 106 (2002) 1211-1218
22. Anderson E.A., Hoffman R.P., and Balon T.W. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 87 (1991) 2246-2252
23. Pedersen-Bjergaard U., Host U., and Kelabaek K. Influence of meal composition on postprandial peripheral plasma concentrations of vasoactive peptides in man. Scand J Clin Lab Invest 56 (1996) 453-497
24. Baliga R.R., Rosen S.D., Camici P.G., et al. Regional myocardial blood flow redistribution as a cause of postprandial angina pectoris. Circulation 97 (1998) 1144-1149
25. Kersten J.R., Brooks L.A., and Dellsperger K.C. Impaired microvascular response to graded coronary occlusion in diabetic and hyperglycemic dogs. Am J Physiol 268 (1995) H1667-H1674
26. Giugliano D., Marfella R., Coppola L., et al. Vascular effects of acute hyperglycemia in humans are reversed by l-arginine. Evidence for reduced availability of nitric oxide during hyperglycemia. Circulation 95 (1997) 1783-1790
27. Pieper G.M., Meier D.A., and Hager S.R. Endothelial dysfunction in a model of hyperglycemia and hyperinsulinemia. Am J Physiol 269 (1995) H845-H850
28. Bohlen H.G., and Lash J.M. Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles. Am J Physiol 265 (1993) H219-H225
29. Kersten J.R., Schmeling T.J., Orth K.G., et al. Acute hyperglycemia abolishes ischemic preconditioning in vivo. Am J Physiol 275 (1998) H721-H725
30. Kersten J.R., Toller W.G., Tessmer J.P., et al. Hyperglycemia reduces coronary collateral blood flow through a nitric oxide-mediated mechanism. Am J Physiol Heart Circ Physiol 281 (2001) H2097-H2104
31. Shipp C.J., Opie L.H., and Challoner D. Fatty acid and glucose metabolism in the perfused heart. Nature 189 (1961) 785-789
32. Cross H.R., Opie L.H., Radda G.K., et al. Is a high glycogen content beneficial or detrimental to the ischemic rat heart?. Circ Res 78 (1996) 482-491
33. Fantini E., Demaison L., Sentex E., et al. Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation. J Mol Cell Cardiol 26 (1994) 949-958
34. Kantor P.F., Lucien A., Kozak R., et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 86 (2000) 580-588
35. MacInness A., Fairman D.A., Binding P., et al. The antianginal trimetazidine does not exert its functional benefit via inhibition of mitochondrial longchain 3-ketoacyl coenzyme A thiolase. Circ Res 93 (2003) e33-e37
36. Oliver M.F., and Opie L.H. Effects of glucose and fatty acids on myocardial ischemia and arrhythmias. Lancet 343 (1994) 155-158
37. Chavez P.N., Stanley W.C., McElfresh T.A., et al. Effect of hyperglycemia and fatty acid inhibition during aerobic conditions and demand-induced ischemia. Am J Physiol Heart Circ Physiol 284 (2003) H1521-H1527
38. Chaitman B.R., Pepine C.J., Parker J.O., et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA 291 (2004) 309-316
39. Lee L., Campbell R., Scheuermann-Freestone M., et al. Metabolic modulation with perhexiline in chronic heart failure. A randomized, controlled trial of short-term use of a novel treatment. Circulation 112 (2005) 3280-3288
40. Lee L., Horowitz J., and Frenneaux M. Metabolic manipulation in ischaemic heart disease, a novel approach to treatment. Eur Heart J 25 (2004) 634-641