Cyclobutane-containing peptides: Evaluation as novel metallocarboxypeptidase inhibitors and modelling of their mode of action

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 11, 2009, Pages 3824-3828

  Fernández, Daniel ^a   Torres, Elisabeth ^a   Avilés, Francesc X ^a   Ortuño, Rosa M ^a   Vendrell, Josep ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Cyclobutane peptide; Human carboxypeptidase B; Inhibitor screening; Ligand docking; Metalloprotease; Non natural amino acid

Indexed keywords

CARBOXYPEPTIDASE; CARBOXYPEPTIDASE B; CYCLOBUTANE DERIVATIVE; FUNCTIONAL GROUP; PEPTIDE DERIVATIVE; PROTEINASE;

ARTICLE; COMPLEX FORMATION; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR INTERACTION;

CARBOXYPEPTIDASES; CYCLOBUTANES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PEPTIDES; RECOMBINANT PROTEINS;

MAMMALIA;

EID: 65549159951     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.035     Document Type: Article

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