Thioxophosphoranyl aryl- and heteroaryloxiranes as the representants of a new class of metallocarboxypeptidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 4823-4828

  Fernández, Daniel ^a   Illa, Ona ^a   Avilés, Francesc X ^a   Branchadell, Vicenç ^a   Vendrell, Josep ^a   Ortuño, Rosa M ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Human carboxypeptidase B; Inhibitor screening; Metallocarboxypeptidases; Thioxophosphoranyl oxiranes

Indexed keywords

ALDEHYDE; CARBENOID; CARBOXYPEPTIDASE; ETHYLENE OXIDE DERIVATIVE; PHOSPHINE; PROTEINASE;

ARTICLE; ATOM; BIOLOGICAL ACTIVITY; COMPARATIVE STUDY; EXPERIMENTAL STUDY; HYDROPHOBICITY; SCREENING; STEREOCHEMISTRY; SYNTHESIS; X RAY DIFFRACTION;

ANIMALS; CARBOXYPEPTIDASES; CATTLE; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ETHYLENE OXIDE; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORYLATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 43049150755     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.047     Document Type: Article

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