Preparation of novel (Z)-4-ylidenebenzo[b]furo[3,2-d][1,3]oxazines and their biological activity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 11, 2009, Pages 3959-3967

  Tabuchi, Yukako ^a   Ando, Yuko ^a   Kanemura, Hidemi ^a   Kawasaki, Ikuo ^a   Ohishi, Takahiro ^b   Koida, Masao ^c   Fukuyama, Ryo ^d   Nakamuta, Hiromichi ^d   Ohta, Shunsaku ^e   Nishide, Kiyoharu ^a   Ohishi, Yoshitaka ^a,f  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

^c SETSUNAN UNIVERSITY   (Japan)

^d Faculty of Pharmaceutical Sciences   (Japan)

^e KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^f Research and Development Dept   (Japan)

Author keywords

Antagonistic activity for the cysLT1 receptor; Anti osteoclastic bone resorption activity; Benzo b furo 3,2 d 1,3 oxazine; Growth inhibitory activity for MIA PaCa 2 and MCF 7

Indexed keywords

(2 ARALKENYLBENZO[B]FURO[3,2 D][1,3]OXAZIN 4 YLIDENE)ACETALDEHYDE DERIVATIVE; 1,3 BUTADIENE; 2 ACETYL 3 ACYLAMINOBENZO[B]FURAN DERIVATIVE; 4 (8 BROMO 2 STYRYLBENZO[B]FURO[3,2 D][1,3]OXAZIN 4 YLIDENE)BUT 2 ENOATE; 4 YLIDENEBENZO[B]FURO[3,2 D][1,3]OXAZINE DERIVATIVE; ESTRADIOL; FORMYLMETHYLENE; PHOSPHONIC ACID DERIVATIVE; REAGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; ISOMER; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; VILSMEIER HAACK REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BONE RESORPTION; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; MALE; MICE; MOLECULAR STRUCTURE; OSTEOBLASTS; OXAZINES; PANCREATIC NEOPLASMS;

AGOUTI PACA;

EID: 65549143033     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.017     Document Type: Article

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