2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease

Journal of Medicinal Chemistry

Volumn 41, Issue 7, 1998, Pages 1060-1067

  Hays, Sheryl J ^a   Caprathe, Bradley W ^a   Gilmore, John L ^a   Amin, Nilam ^a   Emmerling, Mark R ^a   Michael, Walter ^a   Nadimpalli, Ravi ^a   Nath, Rathna ^a   Raser, Kadee J ^a   Stafford, Daniel ^a   Watson, Desiree ^a   Wang, Kevin ^a   Jaen, Juan C ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 IODOPHENYL) 4H 3,1 BENZOXAZIN 4 ONE; 4H 3,1 BENZOXAZIN 4 ONE DERIVATIVE; 7 CHLORO 2 [(2 IODOPHENYL)AMINO]BENZ[D][1,3]OXAZIN 4 ONE; 7 METHYL 2 [(2 IODOPHENYL)AMINO]BENZ[D][1,3]OXAZIN 4 ONE; AMYLOID BETA PROTEIN; COMPLEMENT COMPONENT C1R; NAFAMSTAT MESILATE; SERINE PROTEINASE INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HEMOLYSIS; NONHUMAN; SHEEP;

COMPLEMENT C1R; OXAZINES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPSIN INHIBITORS;

EID: 14444272314     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970394d     Document Type: Article

References (16)

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