A short synthesis of de-'prenyl'-ardeemin

Tetrahedron Letters

Volumn 44, Issue 16, 2003, Pages 3367-3369

  Hernández, Fernando ^a   Avendaño, Carmen ^a   Söllhuber, Mónica ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Acid promoted cyclizations; Ardeemins; Pyrroloindole; Quinazolinediones

Indexed keywords

ESTER DERIVATIVE; QUINAZOLINE DERIVATIVE; SELEGILINE;

ACYLATION; ARTICLE; CYCLIZATION; DRUG SYNTHESIS; NUCLEAR OVERHAUSER EFFECT; STEREOCHEMISTRY;

EID: 0037436919     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)00556-2     Document Type: Article

References (21)

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4. For reviews in this area, see: (a) Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells; Robinson, I. B., Ed.; Plenum Press: New York, 1991; (b) Avendaño, C.; Menéndez, J. C. Curr. Med. Chem 2002, 9, 1867-1901.
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16. 2: C, 70.38; H, 5.06; N, 15.63. Found: C, 69.97; H, 5.46; N, 15,47.
17. The enantiomeric purity was measured by chiral HPLC using a Chiracel OD column (26 cm×0.25 cm), UV-detection at 254 nm, employing hexane/2-propanol 9/1.
18. 2Ar).
19. 20 The chemical shift values of the C-1 carbon atom are higher in these compounds compared to the 1,4-anti isomers, where the C-1 substituent is pseudoequatorial (δ∼52).
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