Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease

Blood

Volumn 113, Issue 16, 2009, Pages 3865-3874

  Sarantopoulos, Stefanie ^a   Stevenson, Kristen E ^a   Kim, Haesook T ^a   Cutler, Corey S ^a   Bhuiya, Nazmim S ^a   Schowalter, Michael ^a   Ho, Vincent T ^a   Alyea, Edwin P ^a   Koreth, John ^a   Blazar, Bruce R ^b   Soiffer, Robert J ^a   Antin, Joseph H ^a   Ritz, Jerome ^a,c  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; CD27 ANTIGEN; IMMUNOGLOBULIN G; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS; ALLOANTIBODY; TNFSF13B PROTEIN, HUMAN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL LEVEL; CHRONIC GRAFT VERSUS HOST DISEASE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; FEMALE; GERMINAL CENTER; GRAFT VERSUS HOST REACTION; HODGKIN DISEASE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IMMUNOSTIMULATION; LOW DRUG DOSE; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MYELOABLATIVE CONDITIONING; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; NONMYELOABLATIVE CONDITIONING; PHENOTYPE; PRIORITY JOURNAL; ALLOTRANSPLANTATION; BLOOD; BLOOD DISEASE; CHRONIC DISEASE; FOLLOW UP; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOMEOSTASIS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; RETROSPECTIVE STUDY;

ADULT; AGED; ANTIGENS, CD27; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTE SUBSETS; CHRONIC DISEASE; FEMALE; FOLLOW-UP STUDIES; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOMEOSTASIS; HUMANS; IMMUNOGLOBULIN G; ISOANTIBODIES; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS;

EID: 65549132114     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-09-177840     Document Type: Article

References (63)

1. Lee SJ, Vogelsang G, Flowers ME. Chronic graft-versus- host disease. Biol Blood Marrow Transplant. 2003;9:215-233.
2. Shlomchik WD, Lee SJ, Couriel D, Pavletic SZ. Transplantation's greatest challenges: advances in chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2007;13:2-10. (Pubitemid 46044113)
3. Abubakar I, Leonardi GS, Edwards N, Herriott N. Inter-rater agreement in defining chemical incidents at the National Poisons Information Service, London. J Epidemiol Community Health. 2004;58:718-722. (Pubitemid 39013112)
4. Goulmy E, Schipper R, Pool J, et al. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N Engl J Med. 1996;334:281-285. (Pubitemid 26033083)
5. Biedermann BC, Sahner S, Gregor M, et al. Endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft versus host disease. Lancet. 2002;359:2078-2083. (Pubitemid 34680972)
6. Cutler C, Kim HT, Hochberg E, et al. Sirolimus and tacrolimus without methotrexate as graft-versus- host disease prophylaxis after matched related donor peripheral blood stem cell transplantation. Biol Blood Marrow Transplant. 2004;10: 328-336. (Pubitemid 38519571)
7. Zhang C, Todorov I, Zhang Z, et al. Donor CD4+ T and B cells in transplants induce chronic graft-versus- host disease with autoimmune manifestations. Blood. 2006;107:2993-3001.
8. Schultz KR, Paquet J, Bader S, HayGlass KT. Requirement for B cells in T cell priming to minor histocompatibility antigens and development of graft-versus-host disease. Bone Marrow Transplant. 1995;16:289-295.
9. Miklos DB, Kim HT, Zorn E, et al. Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors. Blood. 2004;103: 353-359. (Pubitemid 38035116)
10. Miklos DB, Kim HT, Miller KH, et al. Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission. Blood. 2005;105:2973-2978.
11. Zorn E, Miklos DB, Floyd BH, et al. Minor histo-compatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation. J Exp Med. 2004;199:1133-1142. (Pubitemid 38619909)
12. Zaja F, Bacigalupo A, Patriarca F, et al. Treatment of refractory chronic GVHD with rituximab: a GITMO study. Bone Marrow Transplant. 2007;40: 273-277.
13. Ratanatharathorn V, Ayash L, Reynolds C, et al. Treatment of chronic graftversus-host disease with anti-CD20 chimeric monoclonal antibody. Biol Blood Marrow Transplant. 2003;9:505-511. (Pubitemid 38351794)
14. Cutler C, Miklos D, Kim HT, et al. Rituximab for steroid-refractory chronic graft-vs.-host disease. Blood. 2006;108:756-762. (Pubitemid 44061381)
15. Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-versus-host syndrome in man: a long-term clinicopathologic study of 20 Seattle patients. Am J Med. 1980;69:204-217.
16. Ferrara JL, Deeg HJ. Graft-versus-host disease. N Engl J Med. 1991;324:667-674.
17. Svegliati S, Olivieri A, Campelli N, et al. Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease. Blood. 2007;110:237-241. (Pubitemid 47026840)
18. Patriarca F, Skert C, Sperotto A, et al. The development of autoantibodies after allogeneic stem cell transplantation is related with chronic graft-vs- host disease and immune recovery. Exp Hematol. 2006;34:389-396.
19. Kier P, Penner E, Bakos S, et al. Autoantibodies in chronic GVHD: high prevalence of antinucleolar antibodies. Bone Marrow Transplant. 1990;6: 93-96. (Pubitemid 20270755)
20. Storek J, Ferrara S, Ku N, Giorgi JV, Champlin RE, Saxon A. B cell reconstitution after human bone marrow transplantation: recapitulation of ontogeny? Bone Marrow Transplant. 1993;12: 387-398.
21. Gorelik L, Gilbride K, Dobles M, Kalled SL, Zandman D, Scott ML. Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells. J Exp Med. 2003;198: 937-945. (Pubitemid 37152930)
22. Sasaki Y, Casola S, Kutok JL, Rajewsky K, Schmidt-Supprian M. TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol. 2004;173:2245-2252. (Pubitemid 39063079)
23. Hsu BL, Harless SM, Lindsley RC, Hilbert DM, Cancro MP. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol. 2002;168:5993-5996.
24. Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ. Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation. J Exp Med. 2008;205:155-168. (Pubitemid 351185723)
25. Harless SM, Lentz VM, Sah AP, et al. Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers. Curr Biol. 2001;11:1986-1989.
26. Cyster JG, Hartley SB, Goodnow CC. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature. 1994;371:389-395.
27. Goodnow CC, Cyster JG, Hartley SB, et al. Self-tolerance checkpoints in B lymphocyte development. Adv Immunol. 1995;59:279-368.
28. Lesley R, Xu Y, Kalled SL, et al. Reduced competitiveness of autoantigenengaged B cells due to increased dependence on BAFF. Immunity. 2004;20:441-453. (Pubitemid 38482122)
29. Thien M, Phan TG, Gardam S, et al. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity. 2004;20:785-798. (Pubitemid 38757447)
30. Cappione A III, Anolik JH, Pugh-Bernard A, et al. Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus. J Clin Invest. 2005;115:3205-3216. (Pubitemid 41567585)
31. Yurasov S, Wardemann H, Hammersen J, et al. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med. 2005; 201:703-711. (Pubitemid 40395116)
32. Samuels J, Ng YS, Coupillaud C, Paget D, Meffre E. Impaired early B cell tolerance in patients with rheumatoid arthritis. J Exp Med. 2005;201:1659-1667. (Pubitemid 40721009)
33. Matsushita T, Hasegawa M, Yanaba K, Kodera M, Takehara K, Sato S. Elevated serum BAFF levels in patients with systemic sclerosis: enhanced BAFF signaling in systemic sclerosis B lymphocytes. Arthritis Rheum. 2006;54:192-201. (Pubitemid 43122202)
34. Groom J, Kalled SL, Cutler AH, et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome. J Clin Invest. 2002;109:59-68. (Pubitemid 34052542)
35. Zhang J, Roschke V, Baker KP, et al. Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J Immunol. 2001; 166:6-10. (Pubitemid 32038409)
36. Mariette X, Roux S, Zhang J, et al. The level of BLyS (BAFF) correlates with the titre of autoanti-bodies in human Sjogren's syndrome. Ann Rheum Dis. 2003;62:168-171. (Pubitemid 36135394)
37. Sarantopoulos S, Stevenson KE, Kim HT et al. High levels of B-cell activating factor in patients with active chronic graft-versus-host-disease. Clin Cancer Res. 2007;13:6107-6114. (Pubitemid 350075069)
38. Fujii H, Cuvelier G, She K, et al. Biomarkers in newly diagnosed pediatric extensive chronic graft-versus-host disease: a report from the Children's Oncology Group. Blood. 2008;111:3276-3285.
39. Lee S. Chronic Graft-Versus-Host Disease. New York, NY: Cambridge University Press; 2004.
40. Alyea EP, Kim HT, Ho V, et al. Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients older than 50 years of age. Blood. 2005; 105:1810-1814. (Pubitemid 40223707)
41. Avery DT, Ellyard JI, Mackay F, Corcoran LM, Hodgkin PD, Tangye SG. Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. J Immunol. 2005;174:4034-4042. (Pubitemid 40395979)
42. Bohnhorst JO, Bjorgan MB, Thoen JE, Natvig JB, Thompson KM. Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjogren's syndrome. J Immunol. 2001;167:3610-3618.
43. Sims GP, Ettinger R, Shirota Y, Yarboro CH, Illei GG, Lipsky PE. Identification and characterization of circulating human transitional B cells. Blood. 2005;105:4390-4398. (Pubitemid 40720786)
44. Arce E, Jackson DG, Gill MA, Bennett LB, Banchereau J, Pascual V. Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus. J Immunol. 2001;167:2361-2369. (Pubitemid 32747551)
45. Odendahl M, Jacobi A, Hansen A, et al. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J Immunol. 2000;165:5970-5979. (Pubitemid 30836213)
46. Storek J, Witherspoon RP, Storb R. Reconstitution of membrane IgD-(mIgD-) B cells after marrow transplantation lags behind the reconstitution of mIgD+ B cells. Blood. 1997;89:350-351.
47. Darce JR, Arendt BK, Wu X, et al. Regulated expression of BAFF-binding receptors during human B differentiation. J Immunol. 2007;179:7276-7286.
48. Schneider P. The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol. 2005;17: 282-289. (Pubitemid 40692663)
49. Miller JP, Stadanlick JE, Cancro MP. Space, selection, and surveillance: setting boundaries with BLyS. J Immunol. 2006;176:6405-6410.
50. Stadanlick JE, Cancro MP. BAFF and the plasticity of peripheral B cell tolerance. Curr Opin Immunol. 2008;20:158-161.
51. Allman DM, Ferguson SE, Lentz VM, Cancro MP. Peripheral B cell maturation: II, heat-stable antigen( hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol. 1993; 151:4431-4444.
52. Nardelli B, Belvedere O, Roschke V, et al. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood. 2001;97:198-204. (Pubitemid 32061261)
53. Shlomchik MJ. Sites and stages of autoreactive B cell activation and regulation. Immunity. 2008;28: 18-28.
54. Panoskaltsis-Mortari A, Tram KV, Price AP, Wendt CH, Blazar BR. A new murine model for bronchiolitis obliterans post-bone marrow transplant. Am J Respir Crit Care Med. 2007;176:713-723.
55. Chan OT, Shlomchik MJ. Cutting edge: B cells promote CD8+ T cell activation in MRL-Fas(lpr) mice independently of MHC class I antigen presentation. J Immunol. 2000;164:1658-1662.
56. Kita H, Lian ZX, Van de Water J, et al. Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells. J Exp Med. 2002;195:113-123.
57. Tsoi MS, Storb R, Jones E, et al. Deposition of IgM and complement at the dermoepidermal junction in acute and chronic cutaneous graft-vs-host disease in man. J Immunol. 1978;120:1485-1492. (Pubitemid 8400378)
58. Storek J, Joseph A, Espino G, et al. Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation. Blood. 2001;98:3505-3512.
59. Sale GE, Alavaikko M, Schaefers KM, Mahan CT. Abnormal CD4:CD8 ratios and delayed germinal center reconstitution in lymph nodes of human graft recipients with graft-versus-host disease (GVHD): an immunohistological study. Exp Hematol. 1992;20:1017-1021.
60. Garvy BA, King LE, Telford WG, Morford LA, Fraker PJ. Chronic elevation of plasma cortico-sterone causes reductions in the number of cycling cells of the B lineage in murine bone marrow and induces apoptosis. Immunology. 1993;80: 587-592.
61. Dunleavy K, Hakim F, Kim HK, et al. B-cell recovery following rituximab-based therapy is associated with perturbations in stromal derived factor-1 and granulocyte homeostasis. Blood. 2005;106: 795-802. (Pubitemid 41076417)
62. Schaumann DH, Tuischer J, Ebell W, Manz RA, Lauster R. VCAM-1-positive stromal cells from human bone marrow producing cytokines for B lineage progenitors and for plasma cells: SDF-1, flt3L, and BAFF. Mol Immunol. 2007;44:1606-1612.
63. Carter RH, Zhao H, Liu X, et al. Expression and occupancy of BAFF-R on B cells in systemic lupus erythematosus. Arthritis Rheum. 2005;52: 3943-3954. (Pubitemid 41798234)