Prostacyclin attenuates oxidative damage of myocytes by opening mitochondrial ATP-sensitive K+ channels via the EP3 receptor

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 5 57-5, 2005, Pages

  Shinmura, Ken ^a   Tamaki, Kayoko ^a   Sato, Toshiaki ^b   Ishida, Hideyuki ^c   Bolli, Roberto ^d  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d University of Louisville School of Medicine   (United States)

Author keywords

Flavoprotein fluorescence; IP receptor; Oxidative stress; Prostaglandin

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; CARBACYCLIN; DIAZOXIDE; FLAVOPROTEIN; GLIBENCLAMIDE; HYDROGEN PEROXIDE; ONO AE 248; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; PROSTACYCLIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E3; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; TRYPAN BLUE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; FLUORESCENCE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MUSCLE CELL; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL SURVIVAL; EPOPROSTENOL; FLAVOPROTEINS; FLUORESCENCE; HYDROGEN PEROXIDE; MITOCHONDRIA; MYOCYTES, CARDIAC; OXIDANTS; OXIDATIVE STRESS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E; RNA, MESSENGER;

EID: 18044393459     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01003.2004     Document Type: Article

References (54)

1. Adderley SR and Fitzgerald DJ. Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2. J Biol Chem 274: 5038-5046, 1999.
2. Akao M, Ohler A, O'Rourke B, and Marban E. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ Res 88: 1267-1275, 2001.
3. Alcindor D, Krolikowski JG, Pagel PS, Warltier DC, and Kersten JR. Cyclooxygenase-2 mediates ischemic, anesthetic, and pharmacologic pre-conditioning in vivo. Anesthesiology 100: 547-554, 2004.
4. 3 receptor-induced neurite refraction: requirement for two different tyrosine kinases. Biochem J 340: 365-369, 1999.
5. Araki H and Lefer AM. Role of prostacyclin in the preservation of ischemic myocardial tissue in the perfused cat heart. Circ Res 47: 757-763, 1980.
6. 3 receptor subtypes. Endocrinology 137: 2572-2579, 1996.
7. Audoly LP, Ma L, Feoktistov I, de Foe SK, Breyer MD, and Breyer RM. Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription. J Pharmacol Exp Ther 289: 140-148, 1999.
8. + current by extracellular ATP in rat ventricular myocytes. Involvement of adenylyl cyclase-induced subsarcolemmal ATP depletion. Circ Res 80: 589-600, 1997.
9. Bolli R, Shinmura K, Tang X, Kodani E, Xuan Y, Guo Y, and Dawn B. Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning. Cardiovasc Res 55: 506-519, 2002.
10. 2 may activate ATP-sensitive potassium channels in the isolated rat heart. Cardiovasc Res 28: 901-905, 1994.
11. Breyer RM, Bagdassarian CK, Myers SA, and Breyer MD. Prostanoid receptors: subtypes and signaling. Annu Rev Pharmacol Toxicol 41: 661-690, 2001.
12. Camitta MG, Gabel SA, Chulada P, Bradbury JA, Langenbach R, Zeldin DC, and Murphy E. Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning. Circulation 104: 2453-2458, 2001.
13. Chiariello M, Golino P, Cappelli-Bigazzi M, Ambrosio G, Tritto I, and Salvatore M. Reduction in infarct size by the prostacyclin analogue iloprost (ZK 36374) after experimental coronary artery occlusion-reperfusion. Am Heart J 115: 499-504, 1988.
14. Donaldson LF, Humphrey PS, Oldfield S, Giblett S, and Grubb BD. Expression and regulation of prostaglandin E receptor subtype mRNAs in rat sensory ganglia and spinal cord in response to peripheral inflammation. Prostaglandins Other Lipid Mediat 63: 109-122, 2001.
15. Dowd NP, Scully M, Adderley SR, Cunningham AJ, and Fitzgerald DJ. Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo. J Clin Invest 108: 585-590, 2001.
16. Farber NE, Pieper GM, Thomas JP, and Gross GJ. Beneficial effects of iloprost in the stunned canine myocardium. Circ Res 62: 204-215, 1988.
17. Forbes RA, Steenbergen C, and Murphy E. Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism. Circ Res 88: 802-809, 2001.
18. 2 in quiescent isolated rat cardiomyocytes. Basic Res Cardiol 96: 623-629, 2001.
19. Gres P, Schulz R, Jansen J, Umschlag C, and Heusch G. Involvement of endogenous prostaglandins in ischemic preconditioning in pigs. Cardiovasc Res 55: 626-632, 2002.
20. 3 receptor signaling. J Biochem (Tokyo) 131: 781-784, 2002.
21. 0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels. Br J Pharmacol 116: 2435-2440, 1995.
22. Hide EJ and Thiemermann C. Sulprostone-induced reduction of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels. Br J Pharmacol 118: 1409-1414, 1996.
23. 3 receptors in the reperfused ischemic pig heart. J Mol Cell Cardiol 32: 285-296, 2000.
24. Hohlfeld T, Strobach H, and Schror K. Stimulation of endogenous prostacyclin protects the reperfused pig myocardium from ischemic injury. J Pharmacol Exp Ther 264: 397-405, 1993.
25. 3) in the nonischemic and ischemic pig heart. Circ Res 81: 765-773, 1997.
26. Ichinose M, Yonemochi H, Sato T, and Saikawa T. Diazoxide triggers cardioprotection against apoptosis induced by oxidative stress. Am J Physiol Heart Circ Physiol 284: H2235-H2241, 2003.
27. Johnston KM, MacLeod BA, and Walker MJ. Effects of aspirin and prostacyclin on arrhythmias resulting from coronary artery ligation and on infarct size. Br J Pharmacol 78: 29-37, 1983.
28. 2 on myocardial infarct size after coronary occlusion in conscious dogs. Circ Res 49: 685-700, 1981.
29. 3 subtype induces neurite retraction via small GTPase Rho. J Biol Chem 271: 29780-29784, 1996.
30. Lefer AM, Ogletree ML, Smith JB, Silver MJ, Nicolaou KC, Barnette WE, and Gasic GP. Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia. Science 200: 52-54, 1978.
31. Lopaschuk GD, Michalak M, Wandler EL, Lerner RW, Piscione TD, Coceani F, and Olley PM. Prostaglandin E receptors in cardiac sarcolemma. Identification and coupling to adenylate cyclase. Circ Res 65: 538-545, 1989.
32. 1 preconditioning in rat hearts. Acta Pharmacol Sin 25: 587-592, 2004.
33. 2 in cardiac myocytes. Hypertension 39: 382-388, 2002.
34. 3 determines G-protein specificity. Nature 365: 166-170, 1993.
35. Narumiya S, Sugimoto Y, and Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol Rev 79: 1193-1226, 1999.
36. Numaguchi Y, Harada M, Osanai H, Hayashi K, Toki Y, Okumura K, Ito T, and Hayakawa T. Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats. Cardiovasc Res 41: 682-688, 1999.
37. Ogletree ML, Lefer AM, Smith JB, and Nicolaou KC. Studies on the protective effect of prostacyclin in acute myocardial ischemia. Eur J Pharmacol 56: 95-103, 1979.
38. Ritchie RH, Rosenkranz AC, Huynh LP, Stephenson T, Kaye DM, and Dusting GJ. Activation of IP prostanoid receptors prevents cardiomyocyte hypertrophy via cAMP-dependent signaling. Am J Physiol Heart Circ Physiol 287: H1179-H1185, 2004.
39. Sato T, Sasaki N, O'Rourke B, and Marban E. Adenosine primes the opening of mitochondrial ATP-sensitive potassium channels: a key step in ischemic preconditioning? Circulation 102: 800-805, 2000.
40. Ca-channel activation by cAMP-dependent protein kinase. Am J Physiol Heart Circ Physiol 272: H1147-H1156, 1997.
41. Shinmura K, Nagai M, Tamaki K, Tani M, and Bolli R. COX-2-derived prostacyclin mediates opioid-induced late phase of preconditioning in isolated rat hearts. Am J Physiol Heart Circ Physiol 283: H2534-H2543, 2002.
42. Shinmura K, Tang X, Wang Y, Xuan Y, Liu S, Takano H, Bhatnagar A, and Bolli R. Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits. Proc Natl Acad Sci USA 97: 10197-10202, 2000.
43. 3 receptor agonists. Br J Pharmacol 139: 1449-1461, 2003.
44. Simpson PJ, Mickelson J, Fantone JC, Gallagher KP, and Lucchesi BR. Iloprost inhibits neutrophil function in vitro and in vivo and limits experimental infarct size in canine heart. Circ Res 60: 666-673, 1987.
45. Sugimoto Y, Narumiya S, and Ichikawa A. Distribution and function of prostanoid receptors: studies from knockout mice. Prog Lipid Res 39: 289-314, 2000.
46. Tsutsumi Y, Oshita S, Kawano T, Kitahata H, Tomiyama Y, Kuroda Y, and Nakaya Y. Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes. Anesthesiology 95: 766-770, 2001.
47. Van der Giessen WJ, Schoutsen B, Tijssen JG, and Verdouw PD. Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig. Br J Pharmacol 87: 23-27, 1986.
48. +-channel opening. Agents Actions Suppl 45: 93-99, 1995.
49. Wayman NS, Hattori Y, McDonald MC, Mota-Filipe H, Cuzzocrea S, Pisano B, Chatterjee PK, and Thiemermann C. Ligands of the peroxisome proliferator- activated receptors (PPAR-γ and PPAR-α) reduce myocardial infarct size. FASEB J 16: 1027-1040, 2002.
50. 2 in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors. Circulation 104: 2210-2215, 2001.
51. 4. Circulation 109: 2462-2468, 2004.
52. Yamaki F, Kaga M, Horinouchi T, Tanaka H, Koike K, Shigenobu K, Toro L, and Tanaka Y. MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms. Naunyn Schmiedebergs Arch Pharmacol 364: 538-550, 2001.
53. 2+ current of rabbits. Am J Physiol Heart Circ Physiol 277: H1369-H1374, 1999.
54. 3 receptor reduces myocardial infarct size in rodents. Arterioscler Thromb Vasc Biol 19: 2141-2147, 1999.