1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5747-5753

  Pati, Hari N ^a   Das, Umashankar ^a   Kawase, Masami ^b   Sakagami, Hiroshi ^c   Balzarini, Jan ^d   De Clercq, Erik ^d   Dimmock, Jonathan R ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b MATSUYAMA UNIVERSITY   (Japan)

^c MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

1 Aryl 3 dimethylamino 1 propanones; Apoptosis; Caspases; Cytotoxicity

Indexed keywords

2 DIMETHYLAMINOMETHYL 2 PROPEN 1 ONE; 3 DIMETHYLAMINO 2 HYDROXYMETHYL 1 PROPANONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; MELPHALAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; NONHUMAN;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROPIOPHENONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43749122347     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.060     Document Type: Article

References (23)

1. Pati H.N., Das U., Sharma R.K., and Dimmock J.R. Mini-Rev. Med. Chem. 7 (2007) 131-139
2. Mutus B., Wagner J.D., Talpas C.J., Dimmock J.R., Phillips O.A., and Reid R.S. Anal. Biochem. 177 (1989) 237-243
3. Dimmock J.R., Raghavan S.K., Logan B.M., and Bigam G.E. Eur. J. Med. Chem. 18 (1983) 248-254
4. th Ed. (2007), Elsevier, Canada, Toronto 902
5. Dimmock J.R., Kumar P., Quail J.W., Pugazhenthi U., Yang J., Chen M., Reid R.S., Allen T.M., Kao G.Y., Cole S.P.C., Batist G., Balzarini J., and De Clercq E. Eur. J. Med. Chem. 30 (1995) 209-217
6. Ojugo A.S.E., McSheehy P.M.J., McIntyre D.J.O., McCoy C., Stubbs M., Leach M.O., Judson I.R., and Griffiths J.R. NMR Biomed. 12 (1999) 495-504
7. Stubbs M., McSheey P.M.J., Griffiths J.R., and Bashford C.L. Mol. Med. Today 6 (2000) 15-19
8. Van den Berg A.P., Wike-Hooley J.L., Van den Berg-Blok A.E., Van der Zee J., and Reinhold H.S. Eur. J. Cancer Clin. Oncol. 18 (1982) 457-462
9. Albert, A. In Selective Toxicity, 7th ed.; Chapman and Hall: London, 1985, pp. 642-643.
10. Pati H.N., Das U., Ramirez-Erosa I.J., Dunlop D.M., Hickie R.A., and Dimmock J.R. Chem. Pharm. Bull. 55 (2007) 511-515
11. Suffness, M.; Douros, J. In Methods in Cancer Research; De Vita, V. T., Jr., Busch, H., Eds.; Academic Press, New York, 1979; Vol. XVI, Part A, p. 84.
12. Bodor N. Adv. Drug Res. 13 (1984) 255-331
13. Boyd M.R., and Paull K.D. Drug Dev. Res. 34 (1995) 91-109
14. Grever M.R., Schepartz S.A., and Chabner B.A. Semin. Oncol. 19 (1992) 622-638
15. Tsurusawa M., Saeki K., and Fujimoto T. Int. J. Hematol. 66 (1997) 79-88
16. BioMedCache 6.1 Windows, BioMedCache, Fujitsu America, Inc., 2003.
17. Hansch C., and Leo A.J. Substituent Constants for Correlation Analysis in Chemistry and Biology (1979), John Wiley and Sons, New York p. 49
18. Statistical Package for Social Sciences, SPSS for Windows, Standard Version, release 13.0, Chicago: SPSS Inc., 2004.
19. Baraldi P.B., Nunez M.Del.C., Tabrizo M.A., De Clercq E., Balzarini J., Bermejo J., Estévez F., and Romagnoli R. J. Med. Chem. 47 (2004) 2877-2886
20. Motohashi N., Wakabayashi H., Kurihara T., Fukushima H., Yamada T., Kawase M., Sohara Y., Tani S., Shirataki Y., Sakagami H., Satoh K., Nakashima H., Molnár A., Spengler G., Gyémánt N., Ugocsai K., and Molnár J. Phytother. Res. 18 (2004) 212-223
21. Das U., Kawase M., Sakagami H., Ideo A., Shimada J., Molnár J., Baráth Z., Bata Z., and Dimmock J.R. Bioorg. Med. Chem. 15 (2007) 3373-3380
22. Takeuchi R., Hoshijima H., Onuki N., Nagasaka H., Chowdbury S.A., Kawase M., and Sakagami H. Anticancer Res. 25 (2005) 4037-4042
23. Das U., Gul H.I., Alcorn J., Shrivastav A., George T., Sharma R.K., Nienaber R.K., De Clercq E., Balzarini J., Kawase M., Kan N., Tanaka T., Tani S., Werbovetz K.A., Yakovich A.J., Manavathu E.K., Stables J.P., and Dimmock J.R. Eur. J. Med. Chem. 41 (2006) 577-585