Synthesis of simplified analogues of eleutherobin via a Claisen rearrangement/RCM strategy

Tetrahedron Asymmetry

Volumn 20, Issue 6-8, 2009, Pages 921-944

  Frankie Mak, S Y ^a   Chiang, Gary C H ^a   Davidson, James E P ^a   Davies, John E ^a   Ayscough, Andrew ^b   Pain, Gilles ^b   Burton, Jonathan W ^a,c   Holmes, Andrew B ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b British Biotech Pharmaceuticals Ltd   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 (TERT BUTYLDIPHENYLSILANYLOXY) 11 OXABICYCLO[6.2.1]UNDECA 4,9 DIENE; 2 METHOXY 2 HYDROXYMETHYL 8 BENZYLOXY 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2,3,4,7,8,9 HEXAHYDROOXONINE; 2 METHOXY 2,9 DIHYDROXYMETHYL 8 BENZYLOXY 2,3,4,7,8,9 HEXAHYDROOXONINE; 2 METHOXY 8 BENZYLOXY 2,3,4,7,8,9 HEXAHYDROOXONINE 2,9 DICARBALDEHYDE; 3 (TERT BUTYLDIPHENYLSILANYLOXY) 4 HYDROXYMETHYL 6 VINYL 5,10 DIOXABICYCLO[7.1.0] DECANE; 3 (TERT BUTYLDIPHENYLSILANYLOXY) 4,6 DIVINYL 5,10 DIOXABICYCLO[7.1.0] DECANE; 3 (TERT BUTYLDIPHENYLSILANYLOXY) 6 VINYL 5,10 DIOXABICYCLO[7.1.0] DECANE 4 CARBALDEHYDE; 3 BENZYLOXY 6 METHOXY 4,6 DIVINYL 5,10 DIOXABICYCLO[7.1.0]DECANE; 4 HYDROXYMETHYL 6 VINYL 5,10 DIOXABICYCLO[7.1.0]UNDECA 4,9 DIENE; 8 (TERT BUTYLDIPHENYLSILANYLOXY) 2 VINYL 2,3,4,7,8,9 HEXAHYDROOXONINE 9 CARBALDEHYDE; 8 (TERT BUTYLDIPHENYLSILANYLOXY) 9 (TERT BUTYLDIPHENYLSILANYL OXYMETHYL) 2 VINYL 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 (TERT BUTYLDIPHENYLSILANYLOXY) 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2 METHOXY 2 PHENYLSELANYLMETHYL 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 (TERT BUTYLDIPHENYLSILANYLOXY) 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2 METHOXY 2 VINYL 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 (TERT BUTYLDIPHENYLSILANYLOXY) 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2 METHOXY 2,3,4,7,8,9 HEXAHYDROOXONINE 2 CARBALDEHYDE; 8 (TERT BUTYLDIPHENYLSILANYLOXY) 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2 METHYLENE 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 (TERT BUTYLDIPHENYLSILANYLOXY) 9 HYDROXYMETHYL 2 VINYL 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 BENZYLOXY 2 METHOXY 2 VINYL 2,3,4,7,8,9 HEXAHYDROOXONINE 9 CARBALDEHYDE; 8 BENZYLOXY 2 METHOXY 2 VINYL 2,3,4,7,8,9 OCTAHYDROOXONINE 2 CARBALDEHYDE; 8 BENZYLOXY 2 METHOXY 2,9 DIVINYL 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 BENZYLOXY 2 METHOXY 2,9 DIVINYL 2,3,4,7,8,9 OCTAHYDROOXONINE; 8 BENZYLOXY 9 (TERT BUTYLDIPHENYLSILANYLOXY METHYL) 2 METHOXY 2 PHENYLSELANYLMETHYL 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 BENZYLOXY 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2 METHOXY 2 VINYL 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 BENZYLOXY 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2 METHOXY 2 VINYL 2,3,4,7,8,9 OCTAHYDROOXONINE; 8 BENZYLOXY 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2 METHOXY 2,3,4,7,8,9 HEXAHYDROOXONINE 2 CARBALDEHYDE; 8 BENZYLOXY 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2 METHOXY 2,3,4,7,8,9 OCTAHYDROOXONINE 2 CARBALEHYDE; 8 BENZYLOXY 9 (TERT BUTYLDIPHENYLSILANYLOXYMETHYL) 2 METHYLENE 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 BENZYLOXY 9 HYDROXYMETHYL 2 METHOXY 2 VINYL 2,3,4,7,8,9 HEXAHYDROOXONINE; 8 BENZYLOXY 9 HYDROXYMETHYL 2 METHOXY 2 VINYL 2,3,4,7,8,9 OCTAHYDROOXONINE; ELEUTHEROBIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CLAISEN REARRANGEMENT; DRUG SYNTHESIS; ENANTIOSELECTIVITY; PRIORITY JOURNAL; RING CLOSING METATHESIS; STRUCTURE ACTIVITY RELATION;

EID: 65549108181     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2009.03.010     Document Type: Article

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