Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 11, 2009, Pages 3879-3886

  Abuo Rahma, Gamal El Din A A ^a   Sarhan, Hatem A ^a   Gad, Gamal F M ^a  

^a Minia University   (Egypt)

Author keywords

Antibacterial; Mannich bases; Norfloxacin; Physicochemical properties

Indexed keywords

1 ETHYL 6 FLUORO 1,4 DIHYDRO 7 [4 (MORPHOLINOMETHYL)PIPERAZIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 1,4 DIHYDRO 7 [4 [(4,5 DIHYDRO 3 METHY 5 OXOPYRAZOL 1 YL)METHYL]PIPERAZIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 7 (4 FORMYLPIPERAZIN 1 YL) 1,4 DIHYDRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [(2,5 DIOXOPYRROLIDIN 1 YL)METHYL]PIPERAZIN 1 YL] 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; MANNICH BASE; NORFLOXACIN; NORFLOXACIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NORFLOXACIN; PHYSICOCHEMICAL PHENOMENA; PIPERAZINES; PSEUDOMONAS;

ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 65549089530     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.027     Document Type: Article

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