An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG)

Journal of Biological Chemistry

Volumn 284, Issue 11, 2009, Pages 7017-7029

  Suarez, Javier ^a,b   Ranguelova, Kalina ^a,d   Jarzecki, Andrzej A ^a,b   Manzerova, Julia ^c   Krymov, Vladimir ^c   Zhao, Xiangbo ^a   Yu, Shengwei ^a   Metlitsky, Leonid ^a   Gerfen, Gary J ^c   Magliozzo, Richard S ^a,b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDUCT RADICALS; CATALASE ACTIVITY; CATALASE-PEROXIDASE; CATALYTIC ROLE; DENSITY FUNCTIONAL THEORY CALCULATIONS; EPR SPECTRA; EPR SPECTROSCOPY; G TENSORS; G-VALUE; HEME PROTEINS; HYPERFINE INTERACTIONS; HYPERFINE SPLITTING; M. TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NEUTRAL PH; RAY COORDINATES; REACTION INTERMEDIATE; SIDE CHAINS; STOPPED-FLOW SPECTROPHOTOMETRY; TIME COURSE; TYROSYL RADICALS; WILD TYPES; Z VALUE;

DENSITY FUNCTIONAL THEORY; ELECTRON RESONANCE; HEMOGLOBIN; PARAMAGNETIC RESONANCE; PLANTS (BOTANY); PORPHYRINS; QUANTUM THEORY; SPECTROPHOTOMETRY;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

CATALASE; HEMOPROTEIN; HYDROGEN PEROXIDE; KATG PROTEIN; METHIONINE; OXYFERROUS HEMOPROTEIN; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; HEME; KATG PROTEIN, MYCOBACTERIUM TUBERCULOSIS; PEROXIDASE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME MECHANISM; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PH; PREDICTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SPECTROPHOTOMETRY; TURNOVER TIME; WILD TYPE; CHEMICAL MODEL; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

MYCOBACTERIUM TUBERCULOSIS;

BACTERIAL PROTEINS; CATALASE; CATALYSIS; HEME; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; MYCOBACTERIUM TUBERCULOSIS; PEROXIDASE; PROTEIN STRUCTURE, TERTIARY;

EID: 65449149104     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808106200     Document Type: Article

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