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Volumn 4, Issue 4, 2009, Pages

Cardiac expression of microsomal triglyceride transfer protein is increased in obesity and serves to attenuate cardiac triglyceride accumulation

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; FATTY ACID; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; CARRIER PROTEIN; INSULIN; TRIACYLGLYCEROL;

EID: 65449137930     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005300     Document Type: Article
Times cited : (30)

References (61)
  • 2
    • 34250019702 scopus 로고    scopus 로고
    • Explaining the decrease in U.S. deaths from coronary disease, 1980-2000
    • Ford ES, Ajani UA, Croft JB, Critchley JA, Labarthe DR, et al. (2007) Explaining the decrease in U.S. deaths from coronary disease, 1980-2000. N Engl J Med 356: 2388-2398.
    • (2007) N Engl J Med , vol.356 , pp. 2388-2398
    • Ford, E.S.1    Ajani, U.A.2    Croft, J.B.3    Critchley, J.A.4    Labarthe, D.R.5
  • 3
    • 34548385838 scopus 로고    scopus 로고
    • Cardiac steatosis in diabetes mellitus: A 1H-magnetic resonance spectroscopy study
    • McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, et al. (2007) Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation 116: 1170-1175.
    • (2007) Circulation , vol.116 , pp. 1170-1175
    • McGavock, J.M.1    Lingvay, I.2    Zib, I.3    Tillery, T.4    Salas, N.5
  • 4
    • 0037371754 scopus 로고    scopus 로고
    • Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging
    • Szczepaniak LS, Dobbins RL, Metzger GJ, Sartoni-D'Ambrosia G, Arbique D, et al. (2003) Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn Reson Med 49: 417-423.
    • (2003) Magn Reson Med , vol.49 , pp. 417-423
    • Szczepaniak, L.S.1    Dobbins, R.L.2    Metzger, G.J.3    Sartoni-D'Ambrosia, G.4    Arbique, D.5
  • 7
    • 4544252278 scopus 로고    scopus 로고
    • Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice
    • Lee Y, Naseem RH, Duplomb L, Park BH, Garry DJ, et al. (2004) Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice. Proc Natl Acad Sci U S A 101: 13624-13629.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13624-13629
    • Lee, Y.1    Naseem, R.H.2    Duplomb, L.3    Park, B.H.4    Garry, D.J.5
  • 9
    • 35448950503 scopus 로고    scopus 로고
    • Forgotten but not gone: The rediscovery of fatty heart, the most common unrecognized disease in America
    • Szczepaniak LS, Victor RG, Orci L, Unger RH (2007) Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America. Circ Res 101: 759-767.
    • (2007) Circ Res , vol.101 , pp. 759-767
    • Szczepaniak, L.S.1    Victor, R.G.2    Orci, L.3    Unger, R.H.4
  • 10
    • 0036285606 scopus 로고    scopus 로고
    • Energy metabolism in the normal and failing heart: Potential for therapeutic interventions
    • Stanley WC, Chandler MP (2002) Energy metabolism in the normal and failing heart: potential for therapeutic interventions. Heart Fail Rev 7: 115-130.
    • (2002) Heart Fail Rev , vol.7 , pp. 115-130
    • Stanley, W.C.1    Chandler, M.P.2
  • 11
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome
    • Unger RH (2003) Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 144: 5159-5165.
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 12
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD (2005) Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85: 1093-1129.
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 13
    • 33847065971 scopus 로고    scopus 로고
    • Induction of cardiac uncoupling protein-2 expression and adenosine 5′-monophosphate-activated protein kinase phosphorylation during early states of diet-induced obesity in mice
    • Somoza B, Guzman R, Cano V, Merino B, Ramos P, et al. (2007) Induction of cardiac uncoupling protein-2 expression and adenosine 5′-monophosphate-activated protein kinase phosphorylation during early states of diet-induced obesity in mice. Endocrinology 148: 924-931.
    • (2007) Endocrinology , vol.148 , pp. 924-931
    • Somoza, B.1    Guzman, R.2    Cano, V.3    Merino, B.4    Ramos, P.5
  • 14
    • 34247882089 scopus 로고    scopus 로고
    • Obesity and atherogenic dyslipidemia
    • Bamba V, Rader DJ (2007) Obesity and atherogenic dyslipidemia. Gastroenterology 132: 2181-2190.
    • (2007) Gastroenterology , vol.132 , pp. 2181-2190
    • Bamba, V.1    Rader, D.J.2
  • 15
    • 33745784213 scopus 로고    scopus 로고
    • Koutsari C, Jensen MD (2006) Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity. J Lipid Res 47: 1643-1650.
    • Koutsari C, Jensen MD (2006) Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity. J Lipid Res 47: 1643-1650.
  • 16
    • 39049116617 scopus 로고    scopus 로고
    • Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men
    • Hammer S, van der Meer RW, Lamb HJ, Schar M, de RA, et al. (2008) Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men. J Clin Endocrinol Metab 93: 497-503.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 497-503
    • Hammer, S.1    van der2    Meer, R.W.3    Lamb, H.J.4    Schar, M.5    de, R.A.6
  • 17
    • 0023124550 scopus 로고
    • Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans
    • Wisneski JA, Gertz EW, Neese RA, Mayr M (1987) Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans. J Clin Invest 79: 359-366.
    • (1987) J Clin Invest , vol.79 , pp. 359-366
    • Wisneski, J.A.1    Gertz, E.W.2    Neese, R.A.3    Mayr, M.4
  • 18
    • 0037316670 scopus 로고    scopus 로고
    • Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
    • Yagyu H, Chen G, Yokoyama M, Hirata K, Augustus A, et al. (2003) Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J Clin Invest 111: 419-426.
    • (2003) J Clin Invest , vol.111 , pp. 419-426
    • Yagyu, H.1    Chen, G.2    Yokoyama, M.3    Hirata, K.4    Augustus, A.5
  • 19
    • 13444268937 scopus 로고    scopus 로고
    • Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
    • Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, et al. (2005) Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res 96: 225-233.
    • (2005) Circ Res , vol.96 , pp. 225-233
    • Chiu, H.C.1    Kovacs, A.2    Blanton, R.M.3    Han, X.4    Courtois, M.5
  • 20
    • 0036143320 scopus 로고    scopus 로고
    • The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    • Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, et al. (2002) The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest 109: 121-130.
    • (2002) J Clin Invest , vol.109 , pp. 121-130
    • Finck, B.N.1    Lehman, J.J.2    Leone, T.C.3    Welch, M.J.4    Bennett, M.J.5
  • 22
    • 13044277575 scopus 로고    scopus 로고
    • Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation
    • Kurtz DM, Rinaldo P, Rhead WJ, Tian L, Millington DS, et al. (1998) Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc Natl Acad Sci U S A 95: 15592-15597.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15592-15597
    • Kurtz, D.M.1    Rinaldo, P.2    Rhead, W.J.3    Tian, L.4    Millington, D.S.5
  • 23
    • 34548754415 scopus 로고    scopus 로고
    • Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats
    • Wilson CR, Tran MK, Salazar KL, Young ME, Taegtmeyer H (2007) Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats. Biochem J 406: 457-467.
    • (2007) Biochem J , vol.406 , pp. 457-467
    • Wilson, C.R.1    Tran, M.K.2    Salazar, K.L.3    Young, M.E.4    Taegtmeyer, H.5
  • 24
    • 0025821485 scopus 로고
    • Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts
    • Saddik M, Lopaschuk GD (1991) Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts. J Biol Chem 266: 8162-8170.
    • (1991) J Biol Chem , vol.266 , pp. 8162-8170
    • Saddik, M.1    Lopaschuk, G.D.2
  • 25
    • 1642403094 scopus 로고    scopus 로고
    • Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O
    • Strawford A, Antelo F, Christiansen M, Hellerstein MK (2004) Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O. Am J Physiol Endocrinol Metab 286: E577-E588.
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Strawford, A.1    Antelo, F.2    Christiansen, M.3    Hellerstein, M.K.4
  • 26
    • 0344301949 scopus 로고    scopus 로고
    • Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: Evidence that the heart has the capacity to synthesize and secrete lipoproteins
    • Nielsen LB, Veniant M, Boren J, Raabe M, Wong JS, et al. (1998) Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins. Circulation 98: 13-16.
    • (1998) Circulation , vol.98 , pp. 13-16
    • Nielsen, L.B.1    Veniant, M.2    Boren, J.3    Raabe, M.4    Wong, J.S.5
  • 27
    • 23244459229 scopus 로고    scopus 로고
    • Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia
    • Adiels M, Boren J, Caslake MJ, Stewart P, Soro A, et al. (2005) Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia. Arterioscler Thromb Vasc Biol 25: 1697-1703.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1697-1703
    • Adiels, M.1    Boren, J.2    Caslake, M.J.3    Stewart, P.4    Soro, A.5
  • 28
    • 34848894878 scopus 로고    scopus 로고
    • Identification of a novel isoform of microsomal triglyceride transfer protein
    • Mohler PJ, Zhu MY, Blade AM, Ham AJ, Shelness GS, et al. (2007) Identification of a novel isoform of microsomal triglyceride transfer protein. J Biol Chem 282: 26981-26988.
    • (2007) J Biol Chem , vol.282 , pp. 26981-26988
    • Mohler, P.J.1    Zhu, M.Y.2    Blade, A.M.3    Ham, A.J.4    Shelness, G.S.5
  • 29
    • 33947429216 scopus 로고    scopus 로고
    • MTP regulated by an alternate promoter is essential for NKT cell development
    • Dougan SK, Rava P, Hussain MM, Blumberg RS (2007) MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med 204: 533-545.
    • (2007) J Exp Med , vol.204 , pp. 533-545
    • Dougan, S.K.1    Rava, P.2    Hussain, M.M.3    Blumberg, R.S.4
  • 30
    • 2642660445 scopus 로고    scopus 로고
    • Apo B100-containing lipoproteins are secreted by the heart
    • Boren J, Veniant MM, Young SG (1998) Apo B100-containing lipoproteins are secreted by the heart. J Clin Invest 101: 1197-1202.
    • (1998) J Clin Invest , vol.101 , pp. 1197-1202
    • Boren, J.1    Veniant, M.M.2    Young, S.G.3
  • 31
    • 0037178848 scopus 로고    scopus 로고
    • Overexpression of apolipoprotein B in the heart impedes cardiac triglyceride accumulation and development of cardiac dysfunction in diabetic mice
    • Nielsen LB, Bartels ED, Bollano E (2002) Overexpression of apolipoprotein B in the heart impedes cardiac triglyceride accumulation and development of cardiac dysfunction in diabetic mice. J Biol Chem 277: 27014-27020.
    • (2002) J Biol Chem , vol.277 , pp. 27014-27020
    • Nielsen, L.B.1    Bartels, E.D.2    Bollano, E.3
  • 32
    • 1042266664 scopus 로고    scopus 로고
    • Apolipoprotein B production reduces lipotoxic cardiomyopathy: Studies in heart-specific lipoprotein lipase transgenic mouse
    • Yokoyama M, Yagyu H, Hu Y, Seo T, Hirata K, et al. (2004) Apolipoprotein B production reduces lipotoxic cardiomyopathy: studies in heart-specific lipoprotein lipase transgenic mouse. J Biol Chem 279: 4204-4211.
    • (2004) J Biol Chem , vol.279 , pp. 4204-4211
    • Yokoyama, M.1    Yagyu, H.2    Hu, Y.3    Seo, T.4    Hirata, K.5
  • 34
    • 0344349000 scopus 로고    scopus 로고
    • Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
    • Raabe M, Veniant MM, Sullivan MA, Zlot CH, Bjorkegren J, et al. (1999) Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest 103: 1287-1298.
    • (1999) J Clin Invest , vol.103 , pp. 1287-1298
    • Raabe, M.1    Veniant, M.M.2    Sullivan, M.A.3    Zlot, C.H.4    Bjorkegren, J.5
  • 35
    • 33644672230 scopus 로고    scopus 로고
    • Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice
    • Park SY, Cho YR, Kim HJ, Higashimori T, Danton C, et al. (2005) Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes 54: 3530-3540.
    • (2005) Diabetes , vol.54 , pp. 3530-3540
    • Park, S.Y.1    Cho, Y.R.2    Kim, H.J.3    Higashimori, T.4    Danton, C.5
  • 36
    • 0025862074 scopus 로고
    • Inverse regulation of glucose transporter Glut4 and G-protein Gs mRNA expression in cardiac myocytes from insulin resistant rats
    • Petersen S, Russ M, Reinauer H, Eckel J (1991) Inverse regulation of glucose transporter Glut4 and G-protein Gs mRNA expression in cardiac myocytes from insulin resistant rats. FEBS Lett 286: 1-5.
    • (1991) FEBS Lett , vol.286 , pp. 1-5
    • Petersen, S.1    Russ, M.2    Reinauer, H.3    Eckel, J.4
  • 37
    • 46749092545 scopus 로고    scopus 로고
    • Role of diet and fuel overabundance in the development and progression of heart failure
    • Chess DJ, Stanley WC (2008) Role of diet and fuel overabundance in the development and progression of heart failure. Cardiovasc Res 79: 269-278.
    • (2008) Cardiovasc Res , vol.79 , pp. 269-278
    • Chess, D.J.1    Stanley, W.C.2
  • 38
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, et al. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-461.
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5
  • 39
    • 57049117856 scopus 로고    scopus 로고
    • Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities
    • Kim I, Xu W, Reed JC (2008) Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7: 1013-1030.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 1013-1030
    • Kim, I.1    Xu, W.2    Reed, J.C.3
  • 40
    • 0035916342 scopus 로고    scopus 로고
    • Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors
    • Hollander MC, Sheikh MS, Yu K, Zhan Q, Iglesias M, et al. (2001) Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. Int J Cancer 96: 22-31.
    • (2001) Int J Cancer , vol.96 , pp. 22-31
    • Hollander, M.C.1    Sheikh, M.S.2    Yu, K.3    Zhan, Q.4    Iglesias, M.5
  • 41
    • 0027966127 scopus 로고
    • Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability
    • Gordon DA, Jamil H, Sharp D, Mullaney D, Yao Z, et al. (1994) Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Proc Natl Acad Sci U S A 91: 7628-7632.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 7628-7632
    • Gordon, D.A.1    Jamil, H.2    Sharp, D.3    Mullaney, D.4    Yao, Z.5
  • 42
    • 0032555195 scopus 로고    scopus 로고
    • Knockout of the abetalipoproteinemia gene in mice: Reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes
    • Raabe M, Flynn LM, Zlot CH, Wong JS, Veniant MM, et al. (1998) Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes. Proc Natl Acad Sci U S A 95: 8686-8691.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8686-8691
    • Raabe, M.1    Flynn, L.M.2    Zlot, C.H.3    Wong, J.S.4    Veniant, M.M.5
  • 43
    • 2442675345 scopus 로고    scopus 로고
    • The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease
    • Ledmyr H, McMahon AD, Ehrenborg E, Nielsen LB, Neville M, et al. (2004) The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease. Circulation 109: 2279-2284.
    • (2004) Circulation , vol.109 , pp. 2279-2284
    • Ledmyr, H.1    McMahon, A.D.2    Ehrenborg, E.3    Nielsen, L.B.4    Neville, M.5
  • 44
    • 0032960890 scopus 로고    scopus 로고
    • Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
    • Jacob S, Machann J, Rett K, Brechtel K, Volk A, et al. (1999) Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48: 1113-1119.
    • (1999) Diabetes , vol.48 , pp. 1113-1119
    • Jacob, S.1    Machann, J.2    Rett, K.3    Brechtel, K.4    Volk, A.5
  • 45
    • 34547588219 scopus 로고    scopus 로고
    • Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
    • Turner N, Bruce CR, Beale SM, Hoehn KL, So T, et al. (2007) Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 56: 2085-2092.
    • (2007) Diabetes , vol.56 , pp. 2085-2092
    • Turner, N.1    Bruce, C.R.2    Beale, S.M.3    Hoehn, K.L.4    So, T.5
  • 46
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, et al. (2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 7: 45-56.
    • (2008) Cell Metab , vol.7 , pp. 45-56
    • Koves, T.R.1    Ussher, J.R.2    Noland, R.C.3    Slentz, D.4    Mosedale, M.5
  • 47
    • 4344601004 scopus 로고    scopus 로고
    • Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts
    • Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, et al. (2004) Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes 53: 2366-2374.
    • (2004) Diabetes , vol.53 , pp. 2366-2374
    • Mazumder, P.K.1    O'Neill, B.T.2    Roberts, M.W.3    Buchanan, J.4    Yun, U.J.5
  • 48
    • 2442492971 scopus 로고    scopus 로고
    • Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women
    • Peterson LR, Herrero P, Schechtman KB, Racette SB, Waggoner AD (2004) Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 109: 2191-2196.
    • (2004) Circulation , vol.109 , pp. 2191-2196
    • Peterson, L.R.1    Herrero, P.2    Schechtman, K.B.3    Racette, S.B.4    Waggoner, A.D.5
  • 49
    • 54249093047 scopus 로고    scopus 로고
    • Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
    • Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, et al. (2008) Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res 49: 2101-2112.
    • (2008) J Lipid Res , vol.49 , pp. 2101-2112
    • Park, T.S.1    Hu, Y.2    Noh, H.L.3    Drosatos, K.4    Okajima, K.5
  • 50
    • 0037339706 scopus 로고    scopus 로고
    • Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production
    • Ye G, Metreveli NS, Ren J, Epstein PN (2003) Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production. Diabetes 52: 777-783.
    • (2003) Diabetes , vol.52 , pp. 777-783
    • Ye, G.1    Metreveli, N.S.2    Ren, J.3    Epstein, P.N.4
  • 51
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
    • Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, et al. (2003) A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A 100: 1226-1231.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3    Aimond, F.4    Nerbonne, J.M.5
  • 52
    • 27844457564 scopus 로고    scopus 로고
    • Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity
    • Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, et al. (2005) Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology 146: 5341-5349.
    • (2005) Endocrinology , vol.146 , pp. 5341-5349
    • Buchanan, J.1    Mazumder, P.K.2    Hu, P.3    Chakrabarti, G.4    Roberts, M.W.5
  • 53
    • 34247626856 scopus 로고    scopus 로고
    • CD36 deficiency rescues lipotoxic cardiomyopathy
    • Yang J, Sambandam N, Han X, Gross RW, Courtois M, et al. (2007) CD36 deficiency rescues lipotoxic cardiomyopathy. Circ Res 100: 1208-1217.
    • (2007) Circ Res , vol.100 , pp. 1208-1217
    • Yang, J.1    Sambandam, N.2    Han, X.3    Gross, R.W.4    Courtois, M.5
  • 54
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Bruning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, et al. (1998) A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 2: 559-569.
    • (1998) Mol Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1    Michael, M.D.2    Winnay, J.N.3    Hayashi, T.4    Horsch, D.5
  • 55
    • 61349113418 scopus 로고    scopus 로고
    • Early atherosclerosis and vascular inflammation in mice with diet-induced type 2 diabetes
    • Bartels ED, Bang CA, Nielsen LB (2009) Early atherosclerosis and vascular inflammation in mice with diet-induced type 2 diabetes. Eur J Clin Invest 39: 190-199.
    • (2009) Eur J Clin Invest , vol.39 , pp. 190-199
    • Bartels, E.D.1    Bang, C.A.2    Nielsen, L.B.3
  • 56
    • 63849154779 scopus 로고    scopus 로고
    • Effect of treatment with human apolipoprotein A-I on atherosclerosis in uremic apolipoprotein-E deficient mice
    • Pedersen TX, Bro S, Andersen MH, Etzerodt M, Jauhiainen M, et al. (2009) Effect of treatment with human apolipoprotein A-I on atherosclerosis in uremic apolipoprotein-E deficient mice. Atherosclerosis 202: 372-381.
    • (2009) Atherosclerosis , vol.202 , pp. 372-381
    • Pedersen, T.X.1    Bro, S.2    Andersen, M.H.3    Etzerodt, M.4    Jauhiainen, M.5
  • 57
    • 35348897272 scopus 로고    scopus 로고
    • Effect of uremia on HDL composition, vascular inflammation, and atherosclerosis in wild-type mice
    • Bang CA, Bro S, Bartels ED, Pedersen TX, Nielsen LB (2007) Effect of uremia on HDL composition, vascular inflammation, and atherosclerosis in wild-type mice. Am J Physiol Renal Physiol 293: F1325-F1331.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Bang, C.A.1    Bro, S.2    Bartels, E.D.3    Pedersen, T.X.4    Nielsen, L.B.5
  • 58
    • 43849106019 scopus 로고    scopus 로고
    • Maternal diabetes causes coordinated down-regulation of genes involved with lipid metabolism in the murine fetal heart
    • Lindegaard ML, Nielsen LB (2008) Maternal diabetes causes coordinated down-regulation of genes involved with lipid metabolism in the murine fetal heart. Metabolism 57: 766-773.
    • (2008) Metabolism , vol.57 , pp. 766-773
    • Lindegaard, M.L.1    Nielsen, L.B.2
  • 59
    • 33750871446 scopus 로고    scopus 로고
    • In vivo murine left ventricular pressure-volume relations by miniaturized conductance micromanometry
    • Georgakopoulos D, Mitzner WA, Chen CH, Byrne BJ, Millar HD, et al. (1998) In vivo murine left ventricular pressure-volume relations by miniaturized conductance micromanometry. Am J Physiol 274: H1416-H1422.
    • (1998) Am J Physiol , vol.274
    • Georgakopoulos, D.1    Mitzner, W.A.2    Chen, C.H.3    Byrne, B.J.4    Millar, H.D.5
  • 61
    • 0036225267 scopus 로고    scopus 로고
    • Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice
    • Bartels ED, Lauritsen M, Nielsen LB (2002) Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice. Diabetes 51: 1233-1239.
    • (2002) Diabetes , vol.51 , pp. 1233-1239
    • Bartels, E.D.1    Lauritsen, M.2    Nielsen, L.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.