Mechanism of action of N-phenyl-N′-(2-chloroethyl)ureas in the colchicine-binding site at the interface between α- and β-tubulin

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3690-3697

  Fortin, Sébastien ^a,b,c   Wei, Lianhu ^d   Moreau, Emmanuel ^c   Labrie, Philippe ^a,b   Petitclerc, Éric ^a   Kotra, Lakshmi P ^d,e,f   C Gaudreault, René ^a  

^a Université Laval   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITÉ CLERMONT AUVERGNE   (France)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

Anticancer drugs; Antimicrotubule agents; Antitubulin agents; CEU; Colchicine binding site ligands; Docking; FlexiDock; Molecular modeling; Phenylchloroethylurea

Indexed keywords

1 (2 CHLOROETHYL) 3 (3 PENTYLPHENYL)UREA; 1 (2 CHLOROETHYL) 3 [3 (4 HYDROXYBUTYL)PHENYL]UREA; 1 (2 CHLOROETHYL) 3 [3 (5 HYDROXYPENTYL)PHENYL]UREA; 1 (2 CHLOROETHYL) 3 [3 (5 METHOXYPENTYL)PHENYL]UREA; 1 (2 CHLOROETHYL) 3 [3 (5 OXOHEXYL)PHENYL]UREA; 1 (2 CHLOROETHYL) 3 [3 (6 HYDROXYHEXYL)PHENYL]UREA; 1 [3 (3 HYDROXY 4 METHOXYPHENETHYL)PHENYL] 3 (2 CHLOROETHYL)UREA; 1 [4 (3 HYDROXY 4 METHOXYSTYRYL)PHENYL] 3 (2 CHLOROETHYL)UREA; ALPHA TUBULIN; ANTINEOPLASTIC AGENT; BETA TUBULIN; COLCHICINE; LIGAND; N PHENYL N' (2 CHLOROETHYL)UREA; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR STRUCTURE INDICES ANALYSIS; COMPARATIVE STUDY; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; HYDROPHOBICITY; MICROTUBULE; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

EID: 65449132864     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.056     Document Type: Article

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