A comparative molecular field and comparative molecular similarity indices analyses (CoMFA and CoMSIA) of N-phenyl-N′-(2-chloroethyl)ureas targeting the colchicine-binding site as anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 1914-1926

  Fortin, Sébastien ^a,b   Labrie, Philippe ^a,b   Moreau, Emmanuel ^c   Wei, Lianhu ^d,e   Kotra, Lakshmi P ^d,e   C Gaudreault, René ^a  

^a Université Laval   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITÉ CLERMONT AUVERGNE   (France)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Antimicrotubule agents; Colchicine binding site; CoMFA; CoMSIA; Phenyl chloroethylurea; Tubulin

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; COLCHICINE; N PHENYL N' (2 CHLOROETHYL)UREA; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER INHIBITION; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; CRYSTAL STRUCTURE; CYTOSKELETON; DRUG ACTIVITY; DRUG BINDING; HUMAN; HUMAN CELL; HYDROPHOBICITY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING; TUMOR CELL; TUMOR GROWTH; X RAY CRYSTALLOGRAPHY;

ANTIMITOTIC AGENTS; BINDING SITES; COLCHICINE; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS; UREA;

EID: 39049164734     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.004     Document Type: Article

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