Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2860-2864

  Li, Xiaoyuan ^a   Shocron, Ellyn ^a   Song, Aimin ^a   Patel, Neela ^a   Sun, Connie L ^a  

^a Poniard Pharmaceuticals Inc   (United States)

Author keywords

Hsp90 inhibitors

Indexed keywords

2 AMINO 4 CHLORO 8 [(4 METHOXY 3,5 DIMETHYLPYRIDIN 2 YL)METHYL] 7,8 DIHYDROPTERIDIN 6(5H) ONE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HEAT SHOCK PROTEIN 90 INHIBITOR; PTERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; PTERIDINES;

EID: 65349183594     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.074     Document Type: Article

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