Novel α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonists: Synthesis and structure-activity relationships of 6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and related compounds

Journal of Medicinal Chemistry

Volumn 39, Issue 6, 1996, Pages 1331-1338

  Ohmori, Junya ^a,b   Kubota, Hirokazu ^a   Shimizu Sasamata, Masao ^a   Okada, Masamichi ^a   Sakamoto, Shuichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b SAITAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; 6 (1H IMIDAZOL 1 YL) 7 NITRO 2,3(1H,4H) PYRIDO[2,3 B]PYRAZINEDIONE; AMPA RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; PYRIDO[2,3 B]PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

BINDING SITE; DRUG CONFORMATION; DRUG SELECTIVITY; REVIEW; SEIZURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; MALE; MICE; MICE, INBRED DBA; MOLECULAR CONFORMATION; NEUROPROTECTIVE AGENTS; RATS; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029981973     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950304+     Document Type: Article

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