Systematic review of the management of canine osteoarthritis

Veterinary Record

Volumn 164, Issue 14, 2009, Pages 418-424

  Sanderson, R O ^a   Beata, C ^b   Flipo, R M ^c   Genevois, J P ^d   Macias, C ^e   Tacke, S ^f   Vezzoni, A ^g   Innes, J F ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b University Hospital ^*  (France)

^c Lille1 University   (France)

^d VETAGRO SUP   (France)

^e Centro Veterinario de Referencia Bahia de Malaga   (Spain)

^f JUSTUS LIEBIG UNIVERSITY   (Germany)

^g Clinica Veterinaria Vezzoni   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANIS FAMILIARIS; CURCUMA LONGA;

EID: 65349151356     PISSN: 00424900     EISSN: None     Source Type: Journal    
DOI: 10.1136/vr.164.14.418     Document Type: Review

References (79)

1. ANON (2007) Definition of alternative medicine. www.m-w.com/dictionary/ alternative+medicine. Accessed August 16, 2007
2. ALTMAN, R. D., DEAN, D. D., MUNIZ, O. E. & HOWELL, D. S. (1989a) Prophylactic treatment of canine osteoarthritis with glycosaminoglycan polysulfuric acid ester. Arthritis and Rheumatism 32, 759-766
3. ALTMAN, R. D., DEAN, D. D., MUNIZ, O. E. & HOWELL, D. S. (1989b) Therapeutic treatment of canine osteoarthritis with glycosaminoglycan polysulfuric acid ester. Arthritis and Rheumatism 32, 1300-1307
4. ARAGON, C. L., HOFMEISTER, E. H. & BUDSBERG, S. C. (2007) Systematic review of clinical trials of treatments for osteoarthritis in dogs. Journal of the American Veterinary Medical Association 230, 514-521
5. BEHETS, C., WILLIAMS, J. M., CHAPPARD, D., DEVOGELAER, J-P. & MANICOURT, D-H. (2004) Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency. Journal of Bone and Mineral Research 19, 1821-1826
6. BOILEAU, C., MARTEL-PELLETIER, J., JOUZEAU, J. Y., NETTER, P., MOLDOVAN, F., LAUFER, S., TRIES, S. & PELLETIER, J. P. (2002) Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors. Journal of Rheumatology 29, 1446-1453
7. BRAINARD, B. M., MEREDITH, C. P., CALLAN, M. B., BUDSBERG, S. C., SHOFER, F. S., DRIESSEN, B. & OTTO, C. M. (2007) Changes in platelet function, hemostasis, and prostaglandin expression after treatment with nonsteroidal anti-inflammatory drugs with various cyclooxygenase selectivities in dogs. American Journal of Veterinary Research 68, 251-257
8. BUDSBERG, S. C., BERGH, M. S., REYNOLDS, L. R. & STREPPA, H. K. (2007) Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial. Veterinary Surgery 36, 234-244
9. BUDSBERG, S. C., JOHNSTON, S. A., SCHWARZ, P. D., DECAMP, C. E. & CLAXTON, R. (1999) Efficacy of etodolac for the treatment of osteoarthritis of the hip joints in dogs. Journal of the American Veterinary Medical Association 214, 206-210
10. BUI, L. M. & BIERER, T. L. (2003) Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs. Veterinary Therapeutics 4, 397-407
11. CARNEY, S. L. (1996) Effect of diacetyl rhein on the development of experimental osteoarthritis. A biochemical investigation. Osteoarthritis and Cartilage 4, 251-261
12. CLEGG, D. O., REDA, D. J-, HARRIS, C. L, KLEIN, M. A., O'DELL, J. R., HOOPER, M. M. & OTHERS (2006) Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine 354, 795-808
13. COCKCROFT, P. & HOLMES, M. (2003) Handbook of Evidence Based Veterinary Medicine, 1st edn. Blackwell Publishing. p 3
14. CONZEMIUS, M. G., APER, R. L. & CORTI, L. B. (2003) Short-term outcome after total elbow arthroplasty in dogs with severe, naturally occurring osteoarthritis. Veterinary Surgery 32, 545-552
15. COOK, J. L. &. PAYNE, J. T. (1997) Surgical treatment of osteoarthritis. Veterinary Clinics of North America: Small Animai Practice 27, 931-944
16. CROOK, T., MCGOWAN, C. & PEAD, M. (2007) Effect of passive stretching on the range of motion of osteoarthritic joints in 10 labrador retrievers. Veterinary Record 160, 545-547
17. DAHLBERG, j., FITCH, G., EVANS, R. B., MCCLURE, S. R. & CONZEMIUS, M. (2005) The evaluation of extracorporeal shockwave therapy in naturally occurring osteoarthritis of the stifle joint in dogs. Veterinary and Comparative Orthopaedics and Traumatology 18, 147-152
18. DEPARLE, L. A., GUPTA, R. C., CANERDY, T. D., GOAD, J. T., D'ALTILIO, M., BAGCHI, M. & BAGCHI, D. (2005) Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs. Journal of Veterinary Pharmacology and Therapeutics 28, 385-390
19. DOBENECKER, B. (2006) Effect of chondroitin sulfate as nutraceutical in dogs with arthropathies. Advances in Pharmacology 53, 467-474
20. DOIG, P. A., PURBRICK, K. A., HARE, J. E. & MCKEOWN, D. B. (2000) Clinical efficacy and tolerance of meloxicam in dogs with chronic osteoarthritis. Canadian Veterinary Journal 41, 296-300
21. ECHIGO, R., MOCHIZUKI, M., NISHIMURA, R. & SASAKI, N. (2006) Suppressive effect of hyaluronan on chondrocyte apoptosis in experimentally induced acute osteoarthritis in dogs. Journal of Veterinary Medical Science 68, 899-902
22. EL HAJJAJI, H., WILLIAMS, J. M., DEVOGELAER, J-P., LENZ, M. E., THONAR, E. J. M. A. & MANICOURT, D-H. (2004) Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis. Osteoarthritis and Cartilage 12, 904-911
23. FDA (2007) Interim evidence-based ranking system for scientific data. www.cfsan.fda. gov/∼dms/hclmgui4. Accessed June 19, 2007
24. FERNANDES, J. C., MARTEL-PELLETIER, J., JOVANOVIC., D., TARDIF, G., DIBATTISTA, J. A., LASCAU-COMAN, V., OTTERNESS, I. G. & PELLETIER, J. P. (1998) The effects of tenidap on canine experimental osteoarthritis: II. Study of the expression of collagenase-1 and interleukin lbeta by in situ hybridization. Journal of Rheumatology 25, 951-958
25. FERNANDES, J. C., MARTEL-PELLETIER, J., OTTERNESS, I. G., LOPEZ-ANAYA, A., MINEAU, F., TARDIF, G. & PELLETIER, J. P. (1995) Effects of tenidap on canine experimental osteoarthritis. I. Morphologic and metalloprotease analysis. Arthritis and Rheumatism 38, 1290-1303
26. GINGERICH, D. A. & STROBEL, J. D. (2003) Use of client-specific outcome measures to assess treatment effects in geriatric, arthritic dogs: controlled clinical evaluation of a nutraceutical. Veterinary Therapeutics 4, 376-386
27. GIRLING, S. L., BELL, S. C., WHITELOCK, R. G., RAYWARD, R. M., THOMSON, D. G., CARTER, S. C., VAUGHAN-THOMAS, A. & INNES, J. F. (2006) Use of biochemical markers of osteoarthritis to investigate the potential disease-modifying effect of tibial plateau levelling osteotomy. Journal of Small Animal Practice 47, 708-714
28. HANSON, P. D., BROOKS, K. C., CASE, J., CONZEMIUS, M., GORDON, W., SCHUESSLER, J. & OTHERS (2006) Efficacy and safety of firocoxib in the management of canine osteoarthritis under field conditions. Veterinary Therapeutics 7, 127-140
29. HAZEWINKEL, H. A. W., VAN DEN BROM, W. E., THEIJSE, L. F. H., POLLMEIER, M. & HANSON, P. D. (2003) Reduced dosage of ketoprofen for the short-term and long-term treatment of joint pain in dogs. Veterinary Record 152, 11-14
30. HIELM-BJORKMAN, A., RAEKALLIO, M., KUUSELA, E., SAARTO, E., MARKKOLA, A. & TULAMO, R. M. (2001 ) Double-blind evaluation of implants of gold wire at acupuncture points in the dog as a treatment for osteoarthritis induced by hip dysplasia. Veterinary Record 149, 452-456
31. HOCHBERG, M. C., ALTMAN, R. D., BRANDT, K. D. & MOSKOWITZ, R.W. (1997) Design and conduct of clinical trials in osteoarthritis: preliminary recommendations from a task force of the Osteoarthritis Research Society. Journal of Rheumatology 24, 792-794
32. HOWELL, D. S., PITA, J. C., MULLER, F. J., MANICOURT, D. H. & ALTMAN, R. D. (1991) Treatment of osteoarthritis with tiaprofenic acid: biochemical and histological protection against cartilage breakdown in the Pond-Nuki canine model. Journal of Rheumatology - Supplement 27, 138-142
33. IMPELLIZERI, J. A., LAU, R. E. & AZZARA, F. A. (1998) Fourteen week clinical evaluation of an oral antioxidant as a treatment for osteoarthritis secondary to canine hip dysplasia. Veterinary Quarterly 20, S107-S108
34. INNES, J. F., BARR, A. R. & SHARIF, M. (2000) Efficacy of oral calcium pentosan polysulphate for the treatment of osteoarthritis of the canine stifle joint secondary to cranial cruciate ligament deficiency. Veterinary Record 146, 433-437
35. INNES, J. F., FULLER, C. J., GROVER, E. R., KELLY, A. L. & BURN, J. F. (2003) Randomised, double-blind, placebo-controlled parallel group study of P54FP for the treatment of dogs with osteoarthritis. Veterinary Record 152, 457-460
36. JOHNSTON, S. A. (1997) Osteoarthritis. Joint anatomy, physiology and pathobiology. Veterinary Clinics of North America - Small Animal Practice 27, 699-723
37. JOVANOVIC., D., CARON, J. P., MARTEL-PELLETIER, J., FERNANDES, J. C., RICKETTS, T. & PELLETIER, J. P. (1997) The therapeutic effects of tenidap in canine experimental osteoarthritis: relationship with biochemical markers. Journal of Rheumatology 24, 916-925
38. KAPATKIN, A. S., TOMASIC., M., BEECH, j., MEADOWS, C., BOSTON, R. C., MAYHEW, P. D., POWERS, M. Y. & SMITH, G. K. (2006) Effects of electrostimulated acupuncture on ground reaction forces and pain scores in dogs with chronic elbow joint arthritis. Journal of the American Veterinary Medical Association 228, 1350-1354
39. KARSDAL, M. A., TANKO, L. B., RIIS, B. J., SONDERGARD, B. C., HENRIKSEN, K., ALTMAN, R. D., QVIST, P. & CHRISTIANSEN, C. (2006) Calcitonin is involved in cartilage homeostasis: is calcitonin a treatment for OA? Osteoarthritis and Cartilage 14, 617-624
40. KEALY, R. D., LAWLER, D. F., BALLAM, J. M., LUST, G., BIERY, D. N., SMITH, G. K. & MANTZ, S. L. (2000) Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs. Journal of the American Veterinary Medical Association 217, 1678-1680
41. LAJEUNESSE, D., MARTEL-PELLETIER, J., FERNANDES, J. C., LAUFER, S. & PELLETIER, J. P. (2004) Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis. Annals of the Rheumatic Diseases 63, 78-83
42. LEVINE, M. & ENSOM, M.H. (1998) Post hoc power analysis for the behavioural sciences. Lawrence Erlbaum Associates
43. UPSCOMB, V. J., AUABADI, F. S., LEES, P., PEAD, M. J. & MUIR, P. (2002) Clinical efficacy and pharmacokinetics of carprofen in the treatment of dogs with osteoarthritis. Veterinary Record 150, 684-689
44. MCCARTHY, G., O'DONOVAN. J., JONES, B., MCALLISTER, H., SEED, M. & MOONEY, C. (2007) Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. Veterinary Journal 174, 54-61
45. MANICOURT, D. H., ALTMAN, R. D., WILLIAMS, J. M., DEVOGELAER, J. P., DRUETZ-VAN EGEREN, A., LENZ, M. E., PIETRYLA, D. & THONAR, E. J. (1999) Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions. Arthritis and Rheumatism 42, 1159-1167
46. MANSA, S., PALMÉR, E., GRøNDAHL. C., LøNAAS, L. & NYMAN, G. (2007) Long-term treatment with carprofen of 80S dogs with osteoarthritis. Veterinary Record 160, 427-430
47. MASTBERGEN, S. C., MARIJNISSEN, A. C., VIANEN, M. E., ZOER, B., VAN ROERMUND, P. M., BIJLSMA, J. W. & LAFEBER, F. P. (2006) Inhibition of COX-2 by celecoxib in the canine groove model of osteoarthritis. Rheumatology 45, 405-413
48. MLACNIK, E.. BOCKSTAHLER, B. A., MÜLLER, M., TETRICK, M. A., NAP, R. C. & ZENTEK, J. (2006) Effects of caloric restriction and a moderate or intense physiotherapy program for treatment of lameness in overweight dogs with osteoarthritis. Journal of the American Veterinary Medical Association 229, 1756-1760
49. MOREAU, M., BOILEAU, C., MARTEL-PELLETIER, J., BRUNET, J., LAUFER, S. & PELLETIER, J-P. (2006) Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity. Journal of Rheumatology 33, 1176-1183
50. MOREAU, M., DUPUIS, J., BONNEAU, N. H. & DESNOYERS, M. (2003) Clinical evaluation of a nutraceutical, carprofen and meloxicam for the treatment of dogs with osteoarthritis. Veterinary Record 152, 323-329
51. MOREAU, M., DUPUIS, J., BONNEAU, N. H. & LÉCUYER, M. (2004) Clinical evaluation of a powder of quality elk velvet antler for the treatment of osteoarthrosis in dogs. Canadian Veterinary Journal 45, 133-139
52. MOREAU, M., LUSSIER, B., DOUCET, M., VINCENT, G., MARTEL-PELLETIER, J. & PELLETIER, J. P. (2007) Efficacy of licofelone in dogs with clinical osteoarthritis. Veterinary Record 160, 584-588
53. MUELLER, M., BOCKSTAHLER, B., SKALICKY, M., MLACNIK, E. & LORINSON, D. (2007) Effects of radial Shockwave therapy on the limb function of dogs with hip osteoarthritis. Veterinary Record 160, 762-765
54. MYERS, S. L., BRANDT, K. D., BURR, D. B., O'CONNOR, B. L. & ALBRECHT, M. (1999) Effects of a Bisphosphonate on bone histomorphometry and dynamics in the canine cruciate deficiency model of osteoarthritis. Journal of Rheumatology 26, 2645-2653
55. MYERS, S. L., BRANDT, K. D. & O'CONNOR, B. L. (1991) Low dose prednisone treatment does not reduce the severity of osteoarthritis in dogs after anterior cruciate ligament transection. Journal of Rheumatology 18, 1856-1862
56. MYERS, E. F., PRITCHETT, E. & JOHNSON, E. Q. (2001) Evidence-based practice guides vs protocols: what's the difference? Journal of the American Dietetic Association 101, 1085-1090
57. NELL, T., BERGMAN, J., HOEIJMAKERS, M., VAN LAAR, P. & HORSPOOL, L. J. (2002) Comparison of vedaprofen and meloxicam in dogs with musculoskeletal pain and inflammation. Journal of Small Animal Practice 43, 208-212
58. PARDY, C. K., MATYAS, J. R. & ZERNICKE R. F. (2004) Doxycyclinc effects on mechanical and morphometrical properties of early- and late-stage osteoarthritic bone following anterior cruciate ligament injury. Journal of Applied Physiology 97, 1254-1260
59. PEAL, A., D'ALTILIO, M., SIMMS, C., ALVEY, M., GUPTA, R. C., GOAD, J. T., CANERDY, T. D., BAGCHI, M. & BAGCHI, D. (2007) Therapeutic efficacy and safety of undenatured typc-II collagen (UC-II) alone or in combination with (-)-hydroxycitric acid and chromemate in arthritic dogs. Journal of Veterinary Pharmacology and Therapeutics 30, 275-278
60. PELLETIER, J. P., BOILEAU, C., BOILY, M., BRUNET, J., MINEAU, F., GENG, C., REBOUL, P., LAUFER, S., LAJEUNESSE, D. & MARTEL-PELLETIER, J. (2005) The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis Research and Therapy 7, R1091-R1102
61. PELLETIER, J. P., CARON, J. P., EVANS, C., ROBBINS, P. D., GEORGESCU, H. I., JOVANOVIC., D., FERNANDES, J. C. & MARTEL-PELLETIER, J. (1997) In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis and Rheumatism 40, 1012-1019
62. PELLETIER, J. P., JOVANOVIC., D., FERNANDES, J. C., MANNING, P., CONNOR, J. R., CURRIE, M. G. & MARTEL-PELLETIER, J. (1999) Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor. Osteoarthritis and Cartilage 7, 416-418
63. PELLETIER, J. P., MINEAU, F., RAYNAULD, J. P., WOESSNER, J. F., Jr. GUNJA-SMITH, Z. & MARTEL-PELLETIER, J. (1994) Intraarticular injections with methyl-prednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis. Arthritis and Rheumatism 37, 414-423
64. PETERSON, K. D. & KEEFE, T. J. (2004) Effects of meloxicam on severity of lameness and other clinical signs of osteoarthritis in dogs. Journal of the American Veterinary Medical Association 225, 1056-1060
65. POLLARD, B., GUILFORD, W. G., ANKENBAUER-PERKINS, K. L. & HEDDERLEY, D. (2006) Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease. New Zealand Veterinary Journal 54, 114-118
66. POLLMEIER, M.. TOULEMONDE, C., FLEISHMAN, C. & HANSON, P. D. (2006) Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis. Veterinary Record 159, 547-551
67. READ, R. A., CULLIS-HILL, D. & JONES, M. P. (1996) Systemic use of pentosan poly-sulphate in the treatment of osteoarthritis. Journal of Small Animal Practice 37, 108-114
68. RICHETTE, P. & BARDIN, T. (2004) Structure-modifying agents for osteoarthritis: an update. Joint, Bone, Spine 71, 18-23
69. ROGACHEFSKY, R. A., DEAN, D. D., HOWELL. D. S. & ALTMAN, R. D. (1993) Treatment of canine osteoarthritis with insulin-like growth factor-1 (IGF-1) and sodium pentosan polysulfate. Osteoarthritis and Cartilage 1, 105-114
70. RYAN, W. G., MOLDAVE, K. & CARITHERS, D. (2006) Clinical effectiveness and safety of a new NSAID, firocoxih: a 1000 dog study. Veterinary Therapeutics 7, 119-126
71. SERNI, U., MANNONI, A. & BENUCCI, M. ( 1999) Is there preliminary in-vivo evidence for an influence of nonsteroidal antiinflammatory drugs on progression in osteoarthritis? Part II - evidence from animal models. Osteoarthritis and Cartilage 7, 351-352
72. SMITH, G., Jr, MYERS, S. L., BRANDT, K. D., MICKLER, E. A. & ALBRECHT, M. E. (2005) Effect of intraarticular hyaluronan injection on vertical ground reaction force and progression of osteoarthritis after anterior cruciate ligament transection. Journal of Rheumatology 32, 325-334
73. SMITH, G. K., PASTER, E. R., POWERS, M. Y., LAWLER, D. F., BIERY, D. N., SHOFER, F. S., MCKELVIE, P. J. & KEALY, R. D. (2006) Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs. Journal of the American Veterinary Medical Association 229, 690-693
74. SMITH, G. N., Jr, MICKLER, E. A., MYERS, S. L. & BRANDT, K. D. (2001) Effect of intraarticular hyaluronan injection on synovial fluid hyaluronan in the early stage of canine post-traumatic osteoarthritis. Journal of Rheumatology 28, 1341-1346
75. SMITH, G. N., Jr, MYERS, S. L., BRANDT, K. D., MICKLER, E. A. & ALBRECHT, M. E. (1999) Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate-deficiency model of osteoarthritis. Arthritis and Rheumatism 42, 545-554
76. TURNER, J. A., DEYO, R. A., LOESER, J. D, VON KORFF, M. & FORDYCE, W. E. (1994) The importance of placebo effects in pain treatment and research. Journal of the American Medical Association 271, 1609-1614
77. VAN VALBURG, A. A., VAN ROERMUND. P. M., MARIJNISSEN, A. C., WENTING, M. J., VERBOUT, A. J., LAFEBER, F. P. & BIJLSMA, J. W. (2000) Joint distraction in treatment of osteoarthritis (II): effects on cartilage in a canine model. Osteoarthritis and Cartilage 8, 1-8
78. VASSEUR, P. B., JOHNSON, A. L., BUDSBERG, S. C., LINCOLN, J. D., TOOMBS, J. P., WHITEHAIR, J. G. & LENTZ, E. L. (1995) Randomized, controlled trial of the efficacy of carprofen, a nonsteroidal anti-inflammatory drug, in the treatment of osteoarthritis in dogs. Journal of the American Veterinary Medical Association 206, 807-811
79. YU, L. P., Jr, BURR, D. B., BRANDT, K. D., O'CONNOR, B. L., RUBINOW, A. & ALBRECHT, M. (1996) Effects of oral doxycycline administration on histomorphometry and dynamics of subchondral bone in a canine model of osteoarthritis. Journal of Rheumatology 23, 137-142