Efficacy and safety of firocoxib in the management of canine osteoarthritis under field conditions

Veterinary Therapeutics

Volumn 7, Issue 2, 2006, Pages 127-140

  Hanson, Peter D ^a   Brooks, Kenneth C ^b   Case, Jerry ^c   Conzemius, Michael ^d   Gordon, Wanda ^d   Schuessler, James ^e   Shelley, Bert ^f   Sifferman, Roger ^f   Drag, Marlene ^a   Alva, Roberto ^a   Bell, Laura ^a   Romano, Davida ^a   Fleishman, Candis ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b Lodi Veterinary Clinic   (United States)

^c Case Veterinary Hospital   (United States)

^d IOWA STATE UNIVERSITY   (United States)

^e Kirkwood Animal Hospital   (United States)

^f Bradford Park Veterinary Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (CYCLOPROPYLMETHOXY) 4 (4 METHYLSULFONYLPHENYL) 5,5 DIMETHYLFURANONE; 3-(CYCLOPROPYLMETHOXY)-4-(4-METHYLSULFONYLPHENYL)-5,5-DIMETHYLFURANONE; DRUG DERIVATIVE; ETODOLAC; GAMMA BUTYROLACTONE; NONSTEROID ANTIINFLAMMATORY AGENT; SULFONE;

ANIMAL; ANIMAL DISEASE; ANIMAL LAMENESS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOG; DOG DISEASE; DRUG EFFECT; FEMALE; JOINT CHARACTERISTICS AND FUNCTIONS; MALE; MULTICENTER STUDY; OSTEOARTHRITIS; PATHOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SAFETY; TREATMENT OUTCOME;

4-BUTYROLACTONE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOG DISEASES; DOGS; ETODOLAC; FEMALE; LAMENESS, ANIMAL; MALE; OSTEOARTHRITIS; RANGE OF MOTION, ARTICULAR; SAFETY; SULFONES; TREATMENT OUTCOME;

EID: 33748176072     PISSN: 15283593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Gilroy DW, Colville-Nash PR: New insights into the role of COX 2 in inflammation. J Mol Med 78:121-129, 2000.
2. Dubois RN, Abramson SB, Crofford L, et al: Cyclooxygenase in biology and disease. FASEB J 12: 1063-1073, 1998.
3. Meade EA, Smich WL, DeWitt DL: Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isoenzymes by aspirin and other nonsteroidal anti-inflammatory drugs. J Biol Chem 268: 6610-6614, 1993.
4. Wilson JE, Chandrasekharan NV, Westover KD, et al: Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res 65:810-818, 2004.
5. McCann ME, Andersen DR, Zhang D, et al: In vitro effects and in vivo efficacy of a novel cyclooxygenase inhibitor in dogs with experimentally induced synovitis. Am J Vet Res 65:503-512, 2004.
6. Li J, DeMello KML, Cheng H, et al: Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl) -5-methanesulfonyl-pyridine. Bioorg Med Chem Lett 14:95-98, 2004.
7. Pollmeier M, Toulemonde C, Fleishman C, Hanson PD: Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis. Vet Rec, in press, 2006.
8. Brideau C, Van Staden C, Chan CC: In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs and cats. Am J Vet Res 62:1755-1760, 2001.
9. Streppa HK, Jones CJ, Budsberg SC: Cyclooxygenase activity of nonsteroidal anti-inflammatory drugs in canine blood. Am J Vet Res 63:91-94, 2002.
10. Gierse JK, Staten NR, Casperson GF, et al: Cloning, expression and selective inhibition of canine cyclooxygenase-1 and cyclooxygenase-2. Vet Ther 3:270-280, 2002.
11. Borer LR, Peel JE, Seewald W, et al: Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. Am J Vet Res 64:1429-1437, 2003.
12. Budsberg SC, Johnston SA, Schwarz PD, et al: Efficacy of etodolac for the treatment of osteoarthritis of the hip joints in dogs. JAVMA 214:206-210, 1999.
13. Riggs CM, DeCamp CE, Soutas-Little RW, et al: Effects of subject velocity on force plate-measured ground reaction forces in healthy greyhounds at the trot. Am J Vet Res 54:1523-1526, 1993.
14. Wong D, Wang M, Cheng Y, Fitzgerald GA: Cardiovascular hazard and non-steroidal anti-inflammatory drugs. Curr Opin Pharmacol 5:204-210, 2005.
15. Spyridakis LK, Bacia JJ, Barsanti JA, Brown SA: Ibuprofen toxicosis in a dog. JAVMA 189:918-919, 1986.
16. Allison MC, Howatson AG, Torrance CJ, et al: Gastrointestinal damage associated with the use of non-steroidal anti-inflammatory drugs. N Engl J Med 327: 749-754, 1992.