Effects of oral doxycycline administration on histomorphometry and dynamics of subchondral bone in a canine model of osteoarthritis

Journal of Rheumatology

Volumn 23, Issue 1, 1996, Pages 137-142

  Lucino, P Yu ^a   Burr, David B ^b,c   Brandt, Kenneth D ^b,c   O'Connor, Brian L ^b   Rubinow, Alan ^b   Albrecht, Marjorie ^b,c  

^a Rheumatology Division

^b Department of Anatomy ^*  (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

Bone formation; Bone resorption; Doxycycline; Osteoarthritis

Indexed keywords

DOXYCYCLINE;

ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; CONTROLLED STUDY; DOG; HISTOMETRY; ORAL DRUG ADMINISTRATION; OSTEOARTHRITIS; OSTEOLYSIS; PRIORITY JOURNAL;

EID: 9044243755     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Bullough PG: The pathology of osteoarthritis. In: Moskowitz RW, Howell DS, Goldberg VM, Mankin JH, eds. Osteoarthritis - Diagnosis and Management. 2nd ed. Philadelphia: WB Saunders, 1992: 39-69.
2. Radin EL: Mechanical aspects of osteoarthrosis. Bull Rheum Dis 1975;26:862-4.
3. Radin EL, Martin RB, Burr DB, et al: Effects of mechanical loading on the tissues of the rabbit knee. J Orthop Res 1984; 2:221-34.
4. Oegeraa TR Jr, Lewis JL, Thompson RC Jr: Role of acute trauma in development of osteoarthritis. Agents Actions 1993; 40:220-3.
5. Brandt K, Braunstein E, Visco D, et al: Cranial (anterior) cruciate ligament transection in the dog: A bona fide model of osteoarthritis, not merely of cartilage injury and repair. J Rheumatol 1991; 18:436-46.
6. Gilbertson EMM: Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog: A study using microradiographic, microangiographic, and fluorescent bone-labelling techniques. Ann Rheum Dis 1975; 34:12-25
7. Dedrick DK, Goldstein SA, Brandt KD, et al: A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed for up to 54 months. Arthritis Rheum 1993;36:1460-7.
8. Yu LP Jr, Smith GN, Brandt KD, et al: Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline. Arthritis Rheum 1992; 35:1150-9.
9. Smith GN Jr, Brandt KD, Hasty KA: Procollagenase is reduced to inactive fragments upon activation in the presence of doxycycline Ann NY Acad Sci 1994; 732:436-8.
10. Rifkin BR, Vernillo AT, Golub I.M, et al: Modulation of bone resorption by tetracyclines. Ann NY Acad Sci 1994; 732:165-80.
11. Kaneko H, Sasaki T, Ramamurthy NS, et al: Tctracycline administration normalizes the structure and acid phosphalase activity of osteoclasts in streptozotocin induced diabetic rats. Anat Rec 1990; 227:427-36.
12. Chowdhury MJ, Moak SA, Greenwald RA: Effect of tetracycline metalloproteinase inhibitors on basal and heparin-stimulated bone resorption by chick osteoclasts. Agents Actions 1993;40:124-8.
13. Simmons DJ, Teitelbaum SL, Rosenberg GD: Altered metabolic rhythm of rabbit osteoblasts by tetracycline. Metab Dis Ret Res 1981;3:51-4.
14. Myers SL, Brandt KD, O'Connor BL, et al: Synovitis and osteoarthritic changes in canine articular cartilage after cruciate ligament transection. Effect of surgical hemostasis. Arthritis Rheum 1990;33:1406-15.
15. Parfitt AM, Drezner MK, Glorieux FH, et al: Bone histomorphometry: Standardization of nomenclature, symbols, and units. J Bone Miner Res 1987;2:595-610.
16. Frost HM: Tetracycline-based histological analysis of bone remodelling. Calcif Tiss Res 1969;3:211-37.
17. Rubinow A, Ratclitfe A, Brandt K, et al: Effects of doxycycline on changes in articular cartilage in the early stages of osteoarthritis in the cruciate-deficient dog (abstr). Arthritis Rheum 1994; (suppl) 37:S344.
18. Kannus P, Sievanen H, Jarvinen M, et al: A cruciate ligament injury produces considerable, permanent osteoporosis in the affected knee. J Bone Min Res 1992;7:1429-34.
19. Harris W, Lavorgna J, Hamblen D, et al: The inhibition of ossification in vivo Clin Orthop Rel Res 1968;61:52-60
20. Simmons DJ, Chang SL, Russell JE, et al: The effect of protracted tetracycline treatment on bone growth and maturation. Clin Orthop 1983;180:253-9.
21. Frost HM: The origin and nature of transients in human bone remodeling dynamics, In: Frame B, Parfitt AM, Duncan H, eds. Clinical Aspects of Metabolic Bone Disease. Amsterdam Excerpta Medica, 1973:124-37
22. Brandt KD, Myers SL, Burr D, et al: Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fiftyfour months after transection of the anterior cruciate ligament. Arthritis Rheum 1991;34 1560-70.
23. Li XJ, Jee WSS, Li YL, Patterson-Buckendahl P: Transient effects of subcutaneously administered prostaglandin E, on cancellous and cortical bone in young adult dogs. Bone 1990;11:353-64
24. Frost HM: Intermediary Organization of the Skeleton. Boca Raton: CRC Press, 1986.