The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.

Arthritis research & therapy

Volumn 7, Issue 5, 2005, Pages

  Pelletier, Jean Pierre ^a   Boileau, Christelle ^a   Boily, Martin ^a   Brunet, Julie ^a   Mineau, François ^a   Geng, Changshen ^a   Reboul, Pascal ^a   Laufer, Stefan ^a   Lajeunesse, Daniel ^a   Martel Pelletier, Johanne ^a  

^a NOTRE DAME HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ADAM PROTEIN; AGGRECANASE 1; AGGRECANASE-1; ARACHIDONATE 5 LIPOXYGENASE; CATHEPSIN; CATHEPSIN K; COLLAGENASE; COLLAGENASE 3; LICOFELONE; LIPOXYGENASE INHIBITOR; MESSENGER RNA; PROCOLLAGEN N PROTEINASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PYRROLE DERIVATIVE;

ANIMAL; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; BIOSYNTHESIS; COMPARATIVE STUDY; DOG; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYME INDUCTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OSTEOARTHRITIS; PATHOLOGY;

ACETIC ACIDS; ADAM PROTEINS; ANIMALS; ANTERIOR CRUCIATE LIGAMENT; ARACHIDONATE 5-LIPOXYGENASE; CATHEPSINS; COLLAGENASES; CYCLOOXYGENASE INHIBITORS; DOGS; DOWN-REGULATION; DRUG EVALUATION; ENZYME INDUCTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIPOXYGENASE INHIBITORS; MATRIX METALLOPROTEINASE 13; OSTEOARTHRITIS; PROCOLLAGEN N-ENDOPEPTIDASE; PYRROLES; RNA, MESSENGER;

EID: 33645717235     PISSN: None     EISSN: 14786362     Source Type: Journal    
DOI: None     Document Type: Article

References (0)