-
2
-
-
0027173443
-
Interferon alfa-2a in advanced renal cell carcinoma: Treatment results and survival in 159 patients with long-term follow-up
-
Minasian LM, Motzer RJ, Gluck L et al (1993) Interferon alfa-2a in advanced renal cell carcinoma: treatment results and survival in 159 patients with long-term follow-up. J Clin Oncol 11:1368-1375 (Pubitemid 23199143)
-
(1993)
Journal of Clinical Oncology
, vol.11
, Issue.7
, pp. 1368-1375
-
-
Minasian, L.M.1
Motzer, R.J.2
Gluck, L.3
Mazumdar, M.4
Vlamis, V.5
Krown, S.E.6
-
3
-
-
0028928749
-
Chemotherapy for advanced renal-cell carcinoma: 1983-1993
-
Yagoda A, bi-Rached B, Petrylak D (1995) Chemotherapy for advanced renal-cell carcinoma: 1983-1993. Semin Oncol 22:42-60
-
(1995)
Semin Oncol
, vol.22
, pp. 42-60
-
-
Yagoda, A.1
Bi-Rached, B.2
Petrylak, D.3
-
4
-
-
0042914703
-
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
-
DOI 10.1200/JCO.2003.02.122
-
Yang JC, Sherry RM, Steinberg SM et al (2003) Randomized study of highdose and low-dose interleukin-2 in patients with metastatic renal cancer. J Clin Oncol 21:3127-3132 (Pubitemid 46606294)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.16
, pp. 3127-3132
-
-
Yang, J.C.1
Sherry, R.M.2
Steinberg, S.M.3
Topalian, S.L.4
Schwartzentruber, D.J.5
Hwu, P.6
Seipp, C.A.7
Rogers-Freezer, L.8
Morton, K.E.9
White, D.E.10
Liewehr, D.J.11
Merino, M.J.12
Rosenberg, S.A.13
-
5
-
-
33846821872
-
Targeted therapy for metastatic renal cell carcinoma
-
DOI 10.1200/JCO.2006.08.5415
-
Motzer RJ, Bukowski RM (2006) Targeted therapy for metastatic renal cell carcinoma. J Clin Oncol 24:5601-5608 (Pubitemid 46631341)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.35
, pp. 5601-5608
-
-
Motzer, R.J.1
Bukowski, R.M.2
-
6
-
-
34247385849
-
Molecular biology of renal cell cancer and the identification of therapeutic targets
-
DOI 10.1200/JCO.2006.08.8948
-
Iliopoulos O (2006) Molecular biology of renal cell cancer and the identification of therapeutic targets. J Clin Oncol 24:5593-5600 (Pubitemid 46631340)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.35
, pp. 5593-5600
-
-
Iliopoulos, O.1
-
7
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
DOI 10.1056/NEJMoa065044
-
Motzer R, Hutson TE, Tomczak P et al (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356:115-124 (Pubitemid 46089672)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
8
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
DOI 10.1056/NEJMoa060655
-
Escudier B, Eisen T, Stadler W et al (2007) Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356:125-134 (Pubitemid 46089673)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
9
-
-
0034901515
-
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
-
Dudkin L, Dilling MB, Cheshire PJ et al (2001) Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumour growth inhibition. Clin Cancer Res 7:1758-1764 (Pubitemid 32708646)
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.6
, pp. 1758-1764
-
-
Dudkin, L.1
Dilling, M.B.2
Cheshire, P.J.3
Harwood, F.C.4
Hollingshead, M.5
Arbuck, S.G.6
Travis, R.7
Sausville, E.A.8
Houghton, P.J.9
-
10
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
-
DOI 10.1038/nm0202-128
-
Guba M, von Breitenbuch P, Steinbauer M et al (2002) Rapamycin inhibits primary and metastatic tumour growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 8:128-135 (Pubitemid 34155123)
-
(2002)
Nature Medicine
, vol.8
, Issue.2
, pp. 128-135
-
-
Guba, M.1
Von Breitenbuch, P.2
Steinbauer, M.3
Koehl, G.4
Flegel, S.5
Hornung, M.6
Bruns, C.J.7
Zuelke, C.8
Farkas, S.9
Anthuber, M.10
Jauch, K.-W.11
Geissler, E.K.12
-
11
-
-
0041802820
-
Targeting mTOR signaling for cancer therapy
-
DOI 10.1016/S1471-4892(03)00071-7, PII S1471489203000717
-
Huang S, Houghton PJ (2003) Targeting mTOR signaling for cancer therapy. Curr Opin Pharmacol 3:371-377 (Pubitemid 36908940)
-
(2003)
Current Opinion in Pharmacology
, vol.3
, Issue.4
, pp. 371-377
-
-
Huang, S.1
Houghton, P.J.2
-
12
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
DOI 10.1038/nm1337
-
Thomas GV, Tran C, Mellinghoff IK et al (2006) Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 12:122-127 (Pubitemid 43050086)
-
(2006)
Nature Medicine
, vol.12
, Issue.1
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
Welsbie, D.S.4
Chan, E.5
Fueger, B.6
Czernin, J.7
Sawyers, C.L.8
-
13
-
-
33750068623
-
mTOR, translation initiation and cancer
-
DOI 10.1038/sj.onc.1209888, PII 1209888
-
Mamane Y, Petroulakis E, Lebacquer O et al (2006) mTOR, translation initiation and cancer. Oncogene 25:6416-6422 (Pubitemid 44582285)
-
(2006)
Oncogene
, vol.25
, Issue.48
, pp. 6416-6422
-
-
Mamane, Y.1
Petroulakis, E.2
LeBacquer, O.3
Sonenberg, N.4
-
14
-
-
33745242315
-
Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
-
DOI 10.1158/0008-5472.CAN-05-2825
-
Del Bufalo D, Ciuffreda L, Trisciuoglio D et al (2006) Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 66:5549-5554 (Pubitemid 43927103)
-
(2006)
Cancer Research
, vol.66
, Issue.11
, pp. 5549-5554
-
-
Del Bufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
Desideri, M.4
Cognetti, F.5
Zupi, G.6
Milella, M.7
-
15
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers CJ, Martin MM, Brunn GJ et al (1995) Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 270:815-822
-
(1995)
J Biol Chem
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
-
16
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ (2004) The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4:335-348 (Pubitemid 38579480)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.5
, pp. 335-348
-
-
Bjornsti, M.-A.1
Houghton, P.J.2
-
18
-
-
0029103330
-
Control of p70 s6 kinase by kinase activity of FRAP in vivo
-
Brown EJ, Beal PA, Keith CT et al (1995) Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature 377:441-446
-
(1995)
Nature
, vol.377
, pp. 441-446
-
-
Brown, E.J.1
Beal, P.A.2
Keith, C.T.3
-
19
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
DOI 10.1126/science.277.5322.99
-
Brunn GJ, Hudson CC, Sekulic A et al (1997) Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277:99-101 (Pubitemid 27450655)
-
(1997)
Science
, vol.277
, Issue.5322
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence Jr., J.C.7
Abraham, R.T.8
-
20
-
-
0025314596
-
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap
-
Lazaris-Karatzas A, Montine KS, Sonenberg N (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature 345:544-547
-
(1990)
Nature
, vol.345
, pp. 544-547
-
-
Lazaris-Karatzas, A.1
Montine, K.S.2
Sonenberg, N.3
-
21
-
-
0030041884
-
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E
-
DOI 10.1073/pnas.93.3.1065
-
Rousseau D, Kaspar R, Rosenwald I et al (1996) Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A 93:1065-1070 (Pubitemid 26054368)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.3
, pp. 1065-1070
-
-
Rousseau, D.1
Kaspar, R.2
Rosenwald, I.3
Gehrke, L.4
Sonenberg, N.5
-
22
-
-
0042031047
-
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
-
DOI 10.1074/jbc.M212770200
-
Arsham AM, Howell JJ, Simon MC (2003) A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 278:29655-29660 (Pubitemid 36962350)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.32
, pp. 29655-29660
-
-
Arsham, A.M.1
Howell, J.J.2
Simon, M.C.3
-
23
-
-
33646550165
-
Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells
-
DOI 10.1128/MCB.26.10.3955-3965.2006
-
Connolly E, Braunstein S, Formenti S et al (2006) Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell Biol 26:3955-3965 (Pubitemid 43726410)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.10
, pp. 3955-3965
-
-
Connolly, E.1
Braunstein, S.2
Formenti, S.3
Schneider, R.J.4
-
24
-
-
32444433450
-
Hypoxia-induced energy stress regulates mRNA translation and cell growth
-
DOI 10.1016/j.molcel.2006.01.010, PII S1097276506000116
-
Liu L, Cash TP, Jones RG et al (2006) Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 21:521-531 (Pubitemid 43228007)
-
(2006)
Molecular Cell
, vol.21
, Issue.4
, pp. 521-531
-
-
Liu, L.1
Cash, T.P.2
Jones, R.G.3
Keith, B.4
Thompson, C.B.5
Simon, M.C.6
-
25
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
DOI 10.1038/ng0594-85
-
Gnarra JR, Tory K, Weng Y et al (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 7:85-90 (Pubitemid 24232386)
-
(1994)
Nature Genetics
, vol.7
, Issue.1
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
Schmidt, L.4
Wei, M.H.5
Li, H.6
Latif, F.7
Liu, S.8
Chen, F.9
Duh, F.-M.10
Lubensky, I.11
Duan, D.R.12
Florence, C.13
Pozzatti, R.14
Walther, M.M.15
Bander, N.H.16
Grossman, H.B.17
Brauch, H.18
Pomer, S.19
Brooks, J.D.20
Isaacs, W.B.21
Lerman, M.I.22
Zbar, B.23
Linehan, W.M.24
more..
-
26
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
DOI 10.1200/JCO.2004.05.061
-
Kim WY, Kaelin WG (2004) Role of VHL gene mutation in human cancer. J Clin Oncol 22:4991-5004 (Pubitemid 46646218)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.24
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
27
-
-
0036527785
-
The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
-
DOI 10.1016/S1535-6108(02)00044-2
-
Maranchie JK, Vasselli JR, Riss J et al (2002) The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1:247-255 (Pubitemid 41039149)
-
(2002)
Cancer Cell
, vol.1
, Issue.3
, pp. 247-255
-
-
Maranchie, J.K.1
Vasselli, J.R.2
Riss, J.3
Bonifacino, J.S.4
Linehan, W.M.5
Klausner, R.D.6
-
28
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M et al (2000) Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2:423-427
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
-
29
-
-
0024976525
-
Rapamycin for immunosuppression in organ allografting
-
Calne RY, Collier DS, Lim S et al (1989) Rapamycin for immunosuppression in organ allografting. Lancet 2(8656):227
-
(1989)
Lancet
, vol.2
, Issue.8656
, pp. 227
-
-
Calne, R.Y.1
Collier, D.S.2
Lim, S.3
-
30
-
-
4644239244
-
Mammalian target of rapamycin inhibition
-
DOI 10.1158/1078-0432.CCR-050008
-
Dutcher JP (2004) Mammalian target of rapamycin inhibition. Clin Cancer Res 10:6382S-6387S (Pubitemid 39287496)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.18
-
-
Dutcher, J.P.1
Motzer, R.J.2
Atkins, M.B.3
Figlin, R.A.4
Kaelin Jr., W.G.5
Stadler, W.M.6
Gordon, M.S.7
George, D.J.8
-
31
-
-
0035870281
-
1 arrest and determine the cellular response to rapamycin
-
Huang S, Liu LN, Hosoi H et al (2001) p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin. Cancer Res 61:3373-3381 (Pubitemid 32695028)
-
(2001)
Cancer Research
, vol.61
, Issue.8
, pp. 3373-3381
-
-
Huang, S.1
Liu, L.N.2
Hosoi, H.3
Dilling, M.B.4
Shikata, T.5
Houghton, P.J.6
-
32
-
-
0037207525
-
1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
-
DOI 10.1182/blood-2002-01-0189
-
Decker T, Hipp S, Ringshausen I et al (2003) Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin. Blood 101:278-285 (Pubitemid 36025919)
-
(2003)
Blood
, vol.101
, Issue.1
, pp. 278-285
-
-
Decker, T.1
Hipp, S.2
Ringshausen, I.3
Bogner, C.4
Oelsner, M.5
Schneller, F.6
Peschel, C.7
-
33
-
-
0029977949
-
Rapamycin resistance tied to defective regulation of p27(Kip1)
-
Luo Y, Marx SO, Kiyokawa H et al (1996) Rapamycin resistance tied to defective regulation of p27Kip1. Mol Cell Biol 16:6744-6751 (Pubitemid 26389733)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.12
, pp. 6744-6751
-
-
Luo, Y.1
Marx, S.O.2
Kiyokawa, H.3
Koff, A.4
Massague, J.5
Marks, A.R.6
-
34
-
-
0027535132
-
1/S-phase growth arrest in T lymphocytes
-
Morice WG, Brunn GJ, Wiederrecht G et al (1993) Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes. J Biol Chem 268:3734-3738 (Pubitemid 23071022)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.5
, pp. 3734-3738
-
-
Morice, W.G.1
Brunn, G.J.2
Wiederrecht, G.3
Siekierka, J.J.4
Abraham, R.T.5
-
35
-
-
0034790016
-
mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
-
DOI 10.1677/erc.0.0080249
-
Yu K, Toral-Barza L, Discafani C et al (2001) mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 8:249-258 (Pubitemid 32947647)
-
(2001)
Endocrine-Related Cancer
, vol.8
, Issue.3
, pp. 249-258
-
-
Yu, K.1
Toral-Barza, L.2
Discafani, C.3
Zhang, W.-G.4
Skotnicki, J.5
Frost, P.6
Gibbons, J.J.7
-
36
-
-
5444260577
-
Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs
-
DOI 10.1023/B:DRUG.0000036685.72140.03
-
Chang SM, Kuhn J, Wen P et al (2004) Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs. Invest New Drugs 22:427-435 (Pubitemid 39619819)
-
(2004)
Investigational New Drugs
, vol.22
, Issue.4
, pp. 427-435
-
-
Chang, S.M.1
Kuhn, J.2
Wen, P.3
Greenberg, H.4
Schiff, D.5
Conrad, C.6
Fink, K.7
Robins, H.I.8
Cloughesy, T.9
De Angelis, L.10
Razier, J.11
Hess, K.12
Dancey, J.13
Prados, M.D.14
-
37
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
DOI 10.1200/JCO.2004.08.116
-
Raymond E, Alexandre J, Faivre S et al (2004) Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 22:2336-2347 (Pubitemid 41115390)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.12
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
Vera, K.4
Materman, E.5
Boni, J.6
Leister, C.7
Korth-Bradley, J.8
Hanauske, A.9
Armand, J.-P.10
-
38
-
-
33750321673
-
A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer
-
DOI 10.1158/1078-0432.CCR-06-0118
-
Hidalgo M, Buckner JC, Erlichman C et al (2006) A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously for 5 days every 2 weeks to patients with advanced cancer. Clin Cancer Res 12:5755-5763 (Pubitemid 44629606)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.19
, pp. 5755-5763
-
-
Hidalgo, M.1
Buckner, J.C.2
Erlichman, C.3
Pollack, M.S.4
Boni, J.P.5
Dukart, G.6
Marshall, B.7
Speicher, L.8
Moore, L.9
Rowinsky, E.K.10
-
39
-
-
33750266504
-
Phase II trial of the mTOR inhibitor everolimus (RAD-001) in metastice melanoma
-
Rao RD, Windschitl HE (2006) Phase II trial of the mTOR inhibitor everolimus (RAD-001) in metastice melanoma. J Clin Oncol 24[Suppl 18]:8043
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
, pp. 8043
-
-
Rao, R.D.1
Windschitl, H.E.2
-
40
-
-
33750241252
-
Summary of results in patients with metastic renal cell cancer (RCC) from phase i studies of RAD001 (everolimus)
-
Porter LL, Burris HA, Jones SF et al (2006) Summary of results in patients with metastic renal cell cancer (RCC) from phase I studies of RAD001 (everolimus). J Clin Oncol 24[Suppl 18]:14599
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
, pp. 14599
-
-
Porter, L.L.1
Burris, H.A.2
Jones, S.F.3
-
41
-
-
33750238350
-
Updated results of a phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas
-
Chawla SP, Tolcher AW, Staddon AP et al (2006). Updated results of a phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas. J Clin Oncol 24[Suppl 18]:9505
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
, pp. 9505
-
-
Chawla, S.P.1
Tolcher, A.W.2
Staddon, A.P.3
-
42
-
-
84873603169
-
CCI-779 potentiates the inhibitory effect of the anti-angiogenesis drug interferon-alpha on the growth of a human renal cell carcinoma in nude mice
-
Pearl River, NY: Wyeth Research
-
Gibbons JJ (2006) CCI-779 potentiates the inhibitory effect of the anti-angiogenesis drug interferon-alpha on the growth of a human renal cell carcinoma in nude mice. RPT-49843. Pearl River, NY: Wyeth Research
-
(2006)
RPT-49843
-
-
Gibbons, J.J.1
-
43
-
-
0036735346
-
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
-
Shi Y, Gera J, Hu L et al (2002) Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res 62:5027-5034 (Pubitemid 34984430)
-
(2002)
Cancer Research
, vol.62
, Issue.17
, pp. 5027-5034
-
-
Shi, Y.1
Gera, J.2
Hu, L.3
Hsu, J.-H.4
Bookstein, R.5
Li, W.6
Lichtenstein, A.7
-
44
-
-
33744829237
-
CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1α/VEGF signaling
-
DOI 10.1593/neo.05820
-
Wan X, Shen N, Mendoza A et al (2006) CCI-779 Inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/HIF-1alpha/VEGF signaling. Neoplasia 8:394-401 (Pubitemid 43830746)
-
(2006)
Neoplasia
, vol.8
, Issue.5
, pp. 394-401
-
-
Wan, X.1
Shen, N.2
Mendoza, A.3
Khanna, C.4
Helman, L.J.5
-
45
-
-
20244367301
-
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
-
Wislez M, Spencer ML, Izzo JG et al (2005) Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic Kras. Cancer Res 65:3226-3235 (Pubitemid 40524605)
-
(2005)
Cancer Research
, vol.65
, Issue.8
, pp. 3226-3235
-
-
Wislez, M.1
Spencer, M.L.2
Izzo, J.G.3
Juroske, D.M.4
Balhara, K.5
Cody, D.D.6
Price, R.E.7
Hittelman, W.N.8
Wistuba, I.I.9
Kurie, J.M.10
-
46
-
-
16844371494
-
Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts
-
DOI 10.1158/0008-5472.CAN-04-3137
-
Wu L, Birle DC, Tannock IF (2005) Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts. Cancer Res 65:2825-2831 (Pubitemid 40490085)
-
(2005)
Cancer Research
, vol.65
, Issue.7
, pp. 2825-2831
-
-
Wu, L.1
Birle, D.C.2
Tannock, I.F.3
-
47
-
-
31544443832
-
The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
-
DOI 10.1182/blood-2005-05-1935
-
Teachey DT, Obzut DA, Cooperman J et al (2006) The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Blood 107:1149-1155 (Pubitemid 43156317)
-
(2006)
Blood
, vol.107
, Issue.3
, pp. 1149-1155
-
-
Teachey, D.T.1
Obzut, D.A.2
Cooperman, J.3
Fang, J.4
Carroll, M.5
Choi, J.K.6
Houghton, P.J.7
Brown, V.I.8
Grupp, S.A.9
-
48
-
-
11344271046
-
Population pharmacokinetics of CCI-779: Correlations to safety and pharmacogenomic responses in patients with advanced renal cancer
-
DOI 10.1016/j.clpt.2004.08.025, PII S000992360400298X
-
Boni JP, Leister C, Bender G et al (2005) Population pharmacokinetics of CCI-779: correlations to safety and pharmacogenomic responses in patients with advanced renal cancer. Clin Pharmacol Ther 77:76-89 (Pubitemid 40075391)
-
(2005)
Clinical Pharmacology and Therapeutics
, vol.77
, Issue.1
, pp. 76-89
-
-
Boni, J.P.1
Leister, C.2
Bender, G.3
Fitzpatrick, V.4
Twine, N.5
Stover, J.6
Dorner, A.7
Immermann, F.8
Burczynski, M.E.9
-
49
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
DOI 10.1200/JCO.2004.08.185
-
Atkins MB, Hidalgo M, Stadler WM et al (2004) Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 22:909-918 (Pubitemid 41103603)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.5
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
Logan, T.F.4
Dutcher, J.P.5
Hudes, G.R.6
Park, Y.7
Liou, S.-H.8
Marshall, B.9
Boni, J.P.10
Dukart, G.11
Sherman, M.L.12
-
50
-
-
0038688097
-
Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors
-
DOI 10.1093/annonc/mdg248
-
Punt CJ, Boni J, Bruntsch U et al (2003) Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumours. Ann Oncol 14:931-937 (Pubitemid 36827210)
-
(2003)
Annals of Oncology
, vol.14
, Issue.6
, pp. 931-937
-
-
Punt, C.J.A.1
Boni, J.2
Bruntsch, U.3
Peters, M.4
Thielert, C.5
-
51
-
-
0042804376
-
Phase 1, bioavailability, and pharmacokinetic study of oral dosage of CCI-779 administered to patients with advanced solid malignancies
-
Forouzesh B, Buckner J, Adjei A et al (2002) Phase 1, bioavailability, and pharmacokinetic study of oral dosage of CCI-779 administered to patients with advanced solid malignancies. Eur J Cancer 38 [Suppl 7]:S54
-
(2002)
Eur J Cancer
, vol.38
, Issue.SUPPL. 7
-
-
Forouzesh, B.1
Buckner, J.2
Adjei, A.3
-
52
-
-
23344454218
-
Update of a phase 1 study of intravenous CCI-779 given in combination with interferon-α to patients with advanced renal cell carcinoma
-
Smith JW, Ko Y-J, Dutcher J et al (2004) Update of a phase 1 study of intravenous CCI-779 given in combination with interferon-α to patients with advanced renal cell carcinoma. J Clin Oncol 22 [Suppl 14]:S4513
-
(2004)
J Clin Oncol
, vol.22
, Issue.SUPPL. 14
-
-
Smith, J.W.1
Ko, Y.-J.2
Dutcher, J.3
-
53
-
-
33750276049
-
Phase 1 study of intravenous CCI-779 in combination with bryostatin-1 in solid tumours
-
Haas NB, Lewis N, Cohen RB et al (2006) Phase 1 study of intravenous CCI-779 in combination with bryostatin-1 in solid tumours. J Clin Oncol 24 [Suppl 18]: 3067
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
, pp. 3067
-
-
Haas, N.B.1
Lewis, N.2
Cohen, R.B.3
-
54
-
-
33644697765
-
Exposureresponse relationships and drug interactions of sirolimus
-
Zimmerman JJ (2004) Exposureresponse relationships and drug interactions of sirolimus. AAPS J 6:e28
-
(2004)
AAPS J
, vol.6
-
-
Zimmerman, J.J.1
-
55
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
DOI 10.1056/NEJMoa021491
-
Yang JC, Haworth L, Sherry RM et al (2003) A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349:427-434 (Pubitemid 36910021)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.5
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
Hwu, P.4
Schwartzentruber, D.J.5
Topalian, S.L.6
Steinberg, S.M.7
Chen, H.X.8
Rosenberg, S.A.9
-
56
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
DOI 10.1200/JCO.2005.03.6723
-
Ratain MJ, Eisen T, Stadler WM et al (2006) Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 24:2505-2512 (Pubitemid 46630627)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.16
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
Flaherty, K.T.4
Kaye, S.B.5
Rosner, G.L.6
Gore, M.7
Desai, A.A.8
Patnaik, A.9
Xiong, H.Q.10
Rowinsky, E.11
Abbruzzese, J.L.12
Xia, C.13
Simantov, R.14
Schwartz, B.15
O'Dwyer, P.J.16
-
57
-
-
0036138580
-
Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
-
DOI 10.1200/JCO.20.1.289
-
Motzer RJ, Bacik J, Murphy BA et al (2002) Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 20:289-296 (Pubitemid 34032623)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.1
, pp. 289-296
-
-
Motzer, R.J.1
Bacik, J.2
Murphy, B.A.3
Russo, P.4
Mazumdar, M.5
-
58
-
-
33746617583
-
Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus
-
DOI 10.1016/j.ejca.2006.03.015, PII S0959804906003546
-
Duran I, Siu LL, Oza AM et al (2006) Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus. Eur J Cancer 42:1875-1880 (Pubitemid 44149096)
-
(2006)
European Journal of Cancer
, vol.42
, Issue.12
, pp. 1875-1880
-
-
Duran, I.1
Siu, L.L.2
Oza, A.M.3
Chung, T.-B.4
Sturgeon, J.5
Townsley, C.A.6
Pond, G.R.7
Seymour, L.8
Niroumand, M.9
-
59
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
DOI 10.1056/NEJMoa066838
-
Hudes G, Carducci M, Tomczak P et al (2007) Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356:2271-2281 (Pubitemid 46849157)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.22
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
Kovacevic, Z.11
Lesovoy, V.12
Schmidt-Wolf, I.G.H.13
Barbarash, O.14
Gokmen, E.15
O'Toole, T.16
Lustgarten, S.17
Moore, L.18
Motzer, R.J.19
-
60
-
-
3142510752
-
Preliminary report of a phase 1 study of intravenous (IV) CCI-779 given in combination with interferon-α (IFN) to patients with advanced renal cell carcinoma (RCC)
-
Abstract 854
-
Dutcher JP, Hudes G, Motzer R et al (2003) Preliminary report of a phase 1 study of intravenous (IV) CCI-779 given in combination with interferon-α (IFN) to patients with advanced renal cell carcinoma (RCC) J Clin Oncol 22:Abstract 854
-
(2003)
J Clin Oncol
, vol.22
-
-
Dutcher, J.P.1
Hudes, G.2
Motzer, R.3
-
61
-
-
0035212815
-
Phase I trial of capecitabine in combination with interferon alpha in patients with metastatic renal cancer: Toxicity and pharmacokinetics
-
DOI 10.1007/s002800100366
-
Chang DZ, Olencki T, Budd GT et al (2001) Phase I trial of capecitabine in combination with interferon alpha in patients with metastatic renal cancer: toxicity and pharmacokinetics. Cancer Chemother Pharmacol 48:493-498 (Pubitemid 33139872)
-
(2001)
Cancer Chemotherapy and Pharmacology
, vol.48
, Issue.6
, pp. 493-498
-
-
Chang, D.Z.1
Olencki, T.2
Budd, G.T.3
Peereboom, D.4
Ganapathi, R.5
Osterwalder, B.6
Bukowski, R.7
-
62
-
-
33750938968
-
Bevacizumab with or without erlotinib in metastatic renal cell carcinoma
-
Abstract 4523
-
Bukowski RM, Kabbinava F, Figlin RA (2006) Bevacizumab with or without erlotinib in metastatic renal cell carcinoma. J Clin Oncol 18S:Abstract 4523
-
(2006)
J Clin Oncol
, vol.18 S
-
-
Bukowski, R.M.1
Kabbinava, F.2
Figlin, R.A.3
-
63
-
-
0142219359
-
Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway
-
Pantuck AJ, Zeng G, Belldegrun AS et al (2003) Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway. Clin Cancer Res 9:4641-4652 (Pubitemid 37323266)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.13
, pp. 4641-4652
-
-
Pantuck, A.J.1
Zeng, G.2
Belldegrun, A.S.3
Figlin, R.A.4
-
64
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
DOI 10.1016/S0092-8674(02)00808-5
-
Kim DH, Sarbassov DD, Ali SM et al (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175 (Pubitemid 34876545)
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 163-175
-
-
Kim, D.-H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
65
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ et al (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868 (Pubitemid 29165088)
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
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