Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression

Acta Pharmacologica Sinica

Volumn 30, Issue 2, 2009, Pages 153-158

  Zhang, Ke Jie ^a,b   Lu, Quan Yi ^b   Niu, Xiao Qing ^b   Zhang, Peng ^b   Zhao, Jiang Ning ^b   Wang, Zhao ^b   Hu, Jia Sheng ^b   Li, Pu ^b   Liu, Wen Li ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

EC109 cell line; Esophageal carcinoma; Growth hibition.; Notch1

Indexed keywords

COMPLEMENTARY DNA; LIPOFECTAMINE; MESSENGER RNA; NOTCH1 RECEPTOR; PROTEIN P53; DNA BINDING PROTEIN; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; E7 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; NOTCH1 PROTEIN, HUMAN; ONCOPROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG TARGETING; ESOPHAGUS CARCINOMA; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 18; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; ANIMAL; DOWN REGULATION; ESOPHAGUS TUMOR; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CELL CYCLE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DOWN-REGULATION; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION; HUMANS; ONCOGENE PROTEINS, VIRAL; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 65349105308     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2008.16     Document Type: Article

References (26)

1. Aster JC, Xu L, Karnell FG, Patriub V, Pui JC, Pear JC, et al. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol 2000; 20: 7505-15.
2. Bresnick EH, Chu J, Christensen HM, Lin B, Norton J. Linking Notch signaling, chromatin remodeling, and T-cell leukemogenesis. J Cell Biochem 2000; 35 (Suppl): 46-53.
3. Yanagawa S, Lee JS, Kakimi K, Matsuda Y, Honjo T, Ishimoto A. Identification of Notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus. J Virol 2000; 74: 9786-91.
4. Osborne B, Miele L. Notch and the immune system. Immunity 1999; 11: 653-63.
5. Bigas A, Martin DI, Milner LA. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol Cell Biol 1998; 18: 2324-33.
6. Milner LA, Bigas A, Kopan R, Brashem-Stein C, Bernstein ID, Martin DI. Inhibition of granulocytic differentiation by mNotch1. Proc Natl Acad Sci USA 1996; 93: 13014-9.
7. Ohishi K, Katayama N, Shiku H, Varnum-Finney B, Bernstein ID. Notch signalling in hematopoiesis. Semin Cell Dev Biol 2003; 14: 143-50.
8. Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med 2002; 8: 979-86.
9. Maillard I, He Y, Warren S. Pear from the yolk sac to the spleen: new roles for notch in regulating hematopoiesis. Immunity 2003; 18: 587-9.
10. Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 2002; 99: 2369-78.
11. Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, Bakkour S, et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med 2000; 6: 1278-81.
12. Joutel A, Tournier-Lasserve E. Notch signalling pathway and human diseases. Semin Cell Dev Biol 1998; 9: 619-25.
13. Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 1996; 183: 2283-91.
14. Sriuranpong V, Borges MW, Ravi RK, Arnold DR, Nelkin BD, Baylin SB, et al. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 2001; 61: 3200-5.
15. Shou J, Ross S, Koeppen H, de Sauvage FJ, Gao WQ. Dynamics of notch expression during murine prostate development and tumorigenesis. Cancer Res 2001; 61: 7291-7.
16. Lu ZM, Liu HT, Gao Y, Xu PR, Yan WH, Xue LX. Notch1 mRNA and protein expression in human esophageal squamous cell carcinoma and normal esophageal tissues. J Huazhong Normal Univ (Natural Science) 2007; 41: 263-7.
17. Qi ZL, Huo X, Zhang B, Yang HW, Qiu B, Peng L, et al. Esophageal carcinoma cell line-EC109 is confirmed a human papillomavirus type 18 positive cell line. J Shantou Univ Med Coll 2006; 19: 136-8.
18. Talora C, Sgroi DC, Crum CP, Dotto GP. Specific downmodulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev 2002; 16: 2252-63.
19. Nefedova Y, Cheng P, Alsina M, Dalton WS, Gabrilovich DI. Involvement of Notch-1 signaling in bone marrow stromamediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood 2004; 103: 3503-10.
20. Zur HH. Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst 2000; 92: 690-8.
21. Zur HH. Papillomavirus infections-a major cause of human cancers. Biochim Biophys Acta 1996; 1288: 55-78.
22. Thierry F, Spyrou G, Yaniv M, Howley P. Two AP1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes. J Virol 1992; 66: 3740-8.
23. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990; 63: 1129-36.
24. Taylor WR, Tark GR. Regulation of the G2/M transition by p53. Oncogene 2001; 20: 1803-15.
25. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282: 1497-501.
26. Lu ZM, Liu HT, Xu PR, Hou GQ, Xue LX. Expression of Notch1 gene in esophageal squamous cell carcinoma cell line EC9706 and its efect on cell apoptosis. Ai Zheng 2007; 26: 1074-9.