Decreased valproate level caused by VPA-glucuronidase inhibition by carbapenem antibiotics

Drug Metabolism Letters

Volumn 2, Issue 4, 2008, Pages 280-285

  Nakamura, Yutaka ^a   Nakahira, Keiko ^a   Mizutani, Takaharu ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Carbapenem antibiotics; Epilepsy; Glucuronidase; Panipenem; Valproic acid

Indexed keywords

BENZYLSULFONYL FLUORIDE; BETA GLUCURONIDASE; BIAPENEM; ESTERASE; IMIPENEM; MEROPENEM; PANIPENEM; SACCHAROLACTONE; VALPROIC ACID; ANTICONVULSIVE AGENT; ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE; DRUG DERIVATIVE; ENZYME INHIBITOR; VALPROIC ACID GLUCURONIDE;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG GLUCURONIDATION; DRUG HYDROLYSIS; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; IC 50; LIVER CYTOSOL; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; CYTOSOL; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; ENZYMOLOGY; HYDROLYSIS; LIVER; METABOLISM;

RATTUS;

ANTI-BACTERIAL AGENTS; ANTICONVULSANTS; CARBAPENEMS; CYTOSOL; DRUG INTERACTIONS; ENZYME INHIBITORS; GLUCURONIDASE; HUMANS; HYDROLYSIS; LIVER; MICROSOMES, LIVER; VALPROIC ACID;

EID: 65249180071     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208786734049     Document Type: Article

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