In vitro activation of valproate glucuronidation by carbapenem antibiotics

Journal of Health Science

Volumn 53, Issue 3, 2007, Pages 302-310

  Mori, Hitomi ^a   Mizutani, Takaharu ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Carbapenem antibiotics; CYP3A4; Drug interaction; Meropenem; Multidrug resistance associated protein 2; P glycoprotein; UDP glucuronosyltransferase; Valproic acid

Indexed keywords

CARBAPENEM; CYTOCHROME P450 2A6; CYTOCHROME P450 3A4; GLUCURONOSYLTRANSFERASE; GLYCOPROTEIN P; IMIPENEM; MEROPENEM; MULTIDRUG RESISTANCE PROTEIN 2; PANIPENEM; VALPROIC ACID;

ARTICLE; BLOOD LEVEL; CHEMICAL STRUCTURE; CONTROLLED STUDY; GLUCURONIDATION; HUMAN; IN VITRO STUDY; INTESTINE ABSORPTION; LIVER METABOLISM; LIVER MICROSOME; NONHUMAN; RAT;

RATTUS;

EID: 34249806317     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.53.302     Document Type: Article

References (25)

1. Mizutani, T. (2003) PM frequencies of major CYPs in asians and caucasians. Drug Metab. Rev., 35, 99-106.
2. Radomynska-Pandya, A., Czernik, P. J., Little, J. M., Battaglia, E. and Mackenzie, P. I. (1999) Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab. Rev., 31, 817-899.
3. Usui, T., Kuno, T., Ueyama, H., Ohkubo, I. and Mizutani, T. (2006) Proximal HNF1 element is essential for the induction of human UDP-glucoronosyltransferase 1A1 by glucocorticoid receptor. Biochem. Pharmacol., 71, 693-701.
4. Negishi, M., Pedersen, L. G., Petrotchenko, E., Shevtsov, S., Gotokhov, A., Kakuta, Y. and Pedersen, L. C. (2001) Structure and function of sulfotransferases. Arch. Biochem. Biophys., 390, 149-157.
5. Mizutani, T. and Hattori, A. (2005) New horizon of MDR1 (P-glycoprotein) study. Drug Metab. Rev., 37, 489-510.
6. Remmer, H., Schoene, B. and Fleischmann, R. A. (1973) Induction of the unspecific microsomal hydroxylase in the human liver. Drug Metab. Dispos., 1, 224-230.
7. Nagai, K., Shimizu, T., Togo, A., Takeya, M., Yokomizo, Y., Sakata, Y., Matsuishi, T. and Kato, H. (1997) Decrease in serum levels of valproic acid during treatment with a new carbapenem, panipenem/betamipron. J. Antimicrob. Chemother., 39, 295-296.
8. Kojima, S., Nadai, M., Kitaichi, K., Wang, L. I., Nabeshima, T. and Hasegawa, T. (1998) Possible mechanism by which the carbapenem antibiotic panipenem decreases the concentration of valproic acid in plasma in rats. Antimicrob. Agents Chemother., 42, 3136-3140.
9. Torii, M., Takiguchi, Y., Saito, F., Izumi, M. and Yokota, M. (2001) Inhibition by carbapenem antibiotic imipenem of intestinal absorption of valproic acid in rats. J. Pharm. Pharmacol., 53, 823-829.
10. Yamamura, N., Imura, K., Naganuma, H. and Nishimura, K. (1999) Panipenem, a carbapenem antibiotic, enhances the glucuronidation of intravenously administered valproic acid in rats. Drug Metab. Dispos., 27, 724-730.
11. Yamamura, N., Imura-Miyoshi, K. and Naganuma, H. (2000) Panipenem, a carbapenem antibiotic, increases the level of hepatic UDP-glucuronic acid in rats. Drug. Metab. Dispos., 28, 1484-1486.
12. Nakajima, Y., Mizobuchi, M., Nakamura, M., Takagi, H., Inagaki, H., Kominami, G., Koike, M. and Yamaguchi, T. (2004) Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats. Drug Metab. Dispos., 32, 1383-1391.
13. Omoda, K., Murakami, T., Yumoto, R., Nagai, J., Maeda, Y., Kiribayashi, Y. and Takano, M. (2005) Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human. J. Pharm. Sci., 94, 1685-1693.
14. Ogawa, K., Yumoto, R., Hamada, N., Nagai, J. and Takano, M. (2006) Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes. Epilepsy Res., 71, 76-87.
15. Yokogawa, K., Iwashita, S., Kubota, A., Sasaki, Y., Ishizaki, J., Kawahara, M., Matsushita, R., Kimura, K., Ichimura, F. and Miyamoto, K. (2001) Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits. Pharm. Res., 18, 1320-1326.
16. Kanou, M., Saeki, K., Kato, T., Takahashi, K. and Mizutani, T. (2002) Study of in vitro glucuronidation of hydroxyquinolines with bovine liver microsomes. Fundam. Clin. Pharmacol., 16, 513-517.
17. Sarkadi, B., Price, E. M., Boucher, R. C., Germann, U. A. and Scarborough, D. A. (1992) Expression of the humanmultidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase. J. Biol. Chem., 267, 4854-4858.
18. 32P]AMP, and cyclic GMP. Biochim. Biophys. Acta, 526, 11-31.
19. Hirano, Y., Uehara, M., Saeki, K., Kato, T., Takahashi, K. and Mizutani, T. (2002) The influence of quinolines on coumarin 7-hydroxylation in bovine liver misrosomes and human CYP2A6. J. Health Sci., 48, 118-125.
20. Hirano, Y. and Mizutani, T. (2003) Study of inhibition of CYP2A6 by some drugs derived from quinoline. J. Pharm. Pharmacol., 55, 1667-1672.
21. Horiuchi, M., Kimura, M., Yokumura, M., Hasebe, N., Arai, T. and Abe, K. (2006) Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with β-lactam antibiotics. Toxicology, 222, 114-124.
22. Perucca, E. (2006) Clinically relevant drug interactions with antiepileptic drugs. Br. J. Clin. Pharmacol., 61, 246-255.
23. Mallet, L., Babin, S. and Morais, J. A. (2004) Valproic acid-induced hyperammonia and thrombocytopenia in an elderly woman. Ann. Pharmacother., 38, 1643-1647.
24. Besag, F. M. and Berry, D. (2006) Interactions between antiepileptic and antipsychotic drugs. Drug Saf., 29, 95-118.
25. De Turck, B. J. G., Diltoer, M. W., Cornelis, P. J. W. W., Maes, V., Spapen, H. D. M., Camu, F. and Huyghens, L. P. (1998) Lowering of plasma valproic acid concentrations during concomitant therapy with meropenem and amikacin. J. Antimicrob. Chemother., 42, 563-564.