Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera

European Journal of Cancer

Volumn 45, Issue 8, 2009, Pages 1494-1509

  Malik, Fayaz ^a   Kumar, Ajay ^a   Bhushan, Shashi ^a   Mondhe, Dilip M ^a   Pal, Harish C ^a   Sharma, Rohit ^a   Khajuria, Anamika ^a   Singh, Surjeet ^a   Singh, Gurdarshan ^a   Saxena, Ajit K ^a   Suri, Krishan A ^a   Qazi, Ghulam N ^a   Singh, Jaswant ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Antitumour; Apoptosis; Costimulatory molecules; HL 60; RNOS; Safety profile; Signalling pathways; Th1 immune up regulation; Th1 Th2 cytokines; Withania somnifera

Indexed keywords

APOPTOSIS INDUCING FACTOR; B7 ANTIGEN; CAMPTOTHECIN; CASPASE 3; CASPASE 8; CASPASE 9; CD40 LIGAND; CYTOCHROME C; DEATH RECEPTOR 4; GAMMA INTERFERON; HERBACEOUS AGENT; INTERLEUKIN 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXYGEN; PROTEIN BAX; REACTIVE NITROGEN SPECIES; STAT3 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR 1; WITHANIA SOMNIFERA EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG FORMULATION; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; IMMUNITY; IMMUNOMODULATION; IMMUNOREACTIVITY; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NATURAL KILLER CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; T LYMPHOCYTE ACTIVATION; TH1 CELL; TUMOR GROWTH; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOTOXICITY TESTS, IMMUNOLOGIC; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; NEOPLASMS; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; T-LYMPHOCYTES; WITHANIA;

EID: 65249169355     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2009.01.034     Document Type: Article

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