1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 9, 2009, Pages 3379-3387

  Bruno, Olga ^a   Brullo, Chiara ^a   Bondavalli, Francesco ^a   Schenone, Silvia ^a   Spisani, Susanna ^b   Falzarano, Maria Sofia ^b   Varani, Katia ^b   Barocelli, Elisabetta ^c   Ballabeni, Vigilio ^c   Giorgio, Carmine ^c   Tognolini, Massimiliano ^c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

1 (2 Hydroxyalkyl) 5 (3 alkyl benzyl phenyl naphthylureido) 1H pyrazole 4 carboxylic acid ethyl esters; fMLP OMe; IL8 CXCL8 (Interleukin 8); N Formyl methionyl leucyl phenylalanine methyl ester; Neutrophil chemotaxis inhibitors; Zymosan induced peritonitis

Indexed keywords

1 (2 HYDROXY 2 PHENYLETHYL) 5 [3 (1 NAPHTHYL)UREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYBUTYL) 5 (3 BENZYLUREIDO) 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYBUTYL) 5 (3 ISOPROPYLUREIDO) 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYBUTYL) 5 [3 (1 NAPHTHYL)UREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYBUTYL) 5 [3 (2 FLUOROPHENYL)UREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYBUTYL) 5 [3 (3 FLUOROPHENYL)UREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYBUTYL) 5 [3 (4 BENZYL)PIPERAZINYLUREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYBUTYL) 5 [3 (4 FLUOROPHENYL)UREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPENTYL) 5 (3 BENZYLUREIDO) 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPENTYL) 5 (3 ISOPROPYLUREIDO) 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPENTYL) 5 [3 (4 BENZYL)PIPERAZINYLUREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPROPYL) 5 (3 BENZYLUREIDO) 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPROPYL) 5 (3 ISOPROPYLUREIDO) 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPROPYL) 5 [3 (1 NAPHTHYL)UREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPROPYL) 5 [3 (2 FLUOROPHENYL)UREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPROPYL) 5 [3 (3 FLUOROPHENYL)UREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPROPYL) 5 [3 (4 BENZYL)PIPERAZINYLUREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; 1 (2 HYDROXYPROPYL) 5 [3 (4 FLUOROPHENYL)UREIDO] 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; ANTIINFLAMMATORY AGENT; CHEMOTAXIS INHIBITOR; DEXAMETHASONE; ESTER DERIVATIVE; INTERLEUKIN 8; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GRANULOCYTE; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NORMAL HUMAN; PERITONITIS;

ANIMALS; CHEMOTAXIS, LEUKOCYTE; DRUG DESIGN; ESTERS; HUMANS; INHIBITORY CONCENTRATION 50; INTERLEUKIN-8; MALE; MICE; MOLECULAR STRUCTURE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PROTEIN BINDING; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 65249146695     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.035     Document Type: Article

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