The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns

Journal of Biological Chemistry

Volumn 284, Issue 10, 2009, Pages 6311-6321

  Deakin, Jon A ^a   Blaum, Bärbel S ^b   Gallagher, John T ^a   Uhrín, Dušan ^b   Lyo, Malcolm ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROPERTIES; BINDING SEQUENCE; DEGREE OF FLEXIBILITY; DERMATAN SULFATE; FURTHER DEVELOPMENT; GEL MOBILITY SHIFT ASSAY; GLYCOSAMINOGLYCANS; HEPARAN; HEPARAN SULFATES; HEPATOCYTE; HIGH AFFINITY; IN-VITRO; N-TERMINAL; NMR CHEMICAL SHIFTS; SINGLE BINDING SITES; TETRASACCHARIDE; TETRASACCHARIDES;

BINDING ENERGY; DIELECTRIC RELAXATION; GELATION; ISOMERS; OLIGOSACCHARIDES; POLYSACCHARIDES;

BINDING SITES;

DERMATAN SULFATE; HEPARAN SULFATE; OLIGOSACCHARIDE; SCATTER FACTOR RECEPTOR; TETRASACCHARIDE; HGF PROTEIN, HUMAN; SCATTER FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SULFATION; ANIMAL; CHEMISTRY; CHO CELL; CRICETULUS; GENETICS; HAMSTER; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DERMATAN SULFATE; HEPARITIN SULFATE; HEPATOCYTE GROWTH FACTOR; HUMANS; OLIGOSACCHARIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 65249134463     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807671200     Document Type: Article

References (51)

1. Birchmeier, C., Birchmeier, W., Gherardi, E., and Vande Woude, G. F. (2003) Nat. Rev. Mol. Cell. Biol. 4, 915-925
2. Bevan, D., Gherardi, E., Fan, T. P., Edwards, D., and Warn, R. (2004) J. Pathol. 203, 831-838
3. Chmielowiec, J., Borowiak, M., Morkel, M., Stradal, T., Munz, B., Werner, S., Wehland, J., Birchmeier, C., and Birchmeier, W. (2007) J. Cell Biol. 177, 151-162
4. Corso, S., Comoglio, P. M., and Giordano, S. (2005) Trends Mol. Med. 11, 284-292
5. Maulik, G., Shrikhande, A., Kijima, T., Ma, P. C., Morrison, P. T., and Salgia, R. (2002) Cytokine Growth Factor Rev. 13, 41-59
6. Mark, M. R., Lokker, N. A., Zioncheck, T. F., Luis, E. A., and Godowski, P. J. (1992) J. Biol. Chem. 267, 26166-26171
7. Deakin, J. A., and Lyon, M. (1999) J. Cell Sci. 112, 1999-2009
8. Lyon, M., Deakin, J. A., and Gallagher, J. T. (2002) J. Biol. Chem. 277, 1040-1046
9. Rubin, J. S., Day, R. M., Breckenridge, D., Atabey, N., Taylor, W. G., Stahl, S. J., Wingfield, P. T., Kaufman, J. D., Schwall, R., and Botaro, D. P. (2001) J. Biol. Chem. 276, 32977-32983
10. Sergeant, N., Lyon, M., Rudland, P. S., Fernig, D. G., and Delehedde, M. (2000) J. Biol. Chem. 275, 17094-17099
11. Van der Voort, R., Taher, T. E. I., Wielenga, V. J. M., Spaargaren, M., Prevo, R., Smit, L., David, G., Hartmann, G., Gherardi, E., and Pals, S. T. (1999) J. Biol. Chem. 274, 6499-6506
12. Lyon, M., Deakin, J., Mizuno, K., Nakamura, T., and Gallagher, J. T. (1994) J. Biol. Chem. 269, 11216-11223
13. Rahmoune, H., Rudland, P. S., Gallagher, J. T., and Fernig, D. G. (1998) Biochemistry 37, 6003-6008
14. Lyon, M., Deakin, J. A., Rahmoune, H., Fernig, D. G., Nakamura, T., and Gallagher, J. T. (1998) J. Biol. Chem. 273, 271-278
15. Beéchard, D., Gentina, T., Delehedde, M., Scherpereel, A., Lyon, M., Aumercier, M., Vazeux, R., Richet, C., Degand, P., Jude, B., Janin, A., Fernig, D. G., Tonnel, A.-B., and Lassalle, P. (2001) J. Biol. Chem. 276, 48341-48349
16. Lietha, D., Chirgadze, D. Y., Mulloy, B., Blundell, T. L., and Gherardi, E. (2001) EMBO J. 20, 5543-5555
17. Gherardi, E., Youles, M. E., Miguel, R. C., Blundell, T. L., Lamele, L., Gough, J., Bandyopadhyay, A., Hartmann, G., and Butler, P. J. G. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 12039-12044
18. Delehedde, M., Lyon, M., Vidyasagar, R., McDonnell, T. J., and Fernig, D. G. (2002) J. Biol. Chem. 277, 12456-12462
19. Lyon, M., Deakin, J. A., Lietha, D., Gherardi, E., and Gallagher, J. T. (2004) J. Biol. Chem. 279, 43560-43567
20. Holmes, O., Pillozzi, S., Deakin, J. A., Carafoli, F., Kemp, L., Butler, P. J. G., Lyon, M., and Gherardi, E. (2007) J. Mol. Biol. 367, 395-408
21. Hartmann, G., Prospero, T., Brinkmann, V., Ozcelik, O., Winter, G., Hepple, J., Batley, S., Bladt, F., Sachs, M., Birchmeier, C., Birchmeier, W., and Gherardi, E. (1997) Curr. Biol. 8, 125-134
22. Mizuno, K., Inoue, H., Hagiya, M., Shimizu, S., Nose, T., Shimohigashi, Y., and Nakamura, T. (1994) J. Biol. Chem. 269, 1131-1136
23. Catlow, K. R., Deakin, J. A., Wei, Z., Delehedde, M., Fernig, D. G., Gherardi, E., Gallagher, J. T., Pavão, M. S. G., and Lyon, M. (2008) J. Biol. Chem. 283, 5235-5248
24. Lyon, M. (2007) in New Developments in Therapeutic Glycomics (Delehedde, M., and Lortat-Jacob, H., eds) pp. 317-350, Research Signpost, Trivandrum, India
25. Raiber, E.-A., Wilkinson, J. A., Manetti, F., Botta, M., Deakin, J., Gallagher, J. T., Lyon, M., and Ducki, S. W. (2007) Bioorg. Med. Chem. Lett. 17, 6321-6325
26. Chirgadze, D. Y., Hepple, J. P., Zhou, H., Byrd, A., Blundell, T. L., and Gherardi, E. (1999) Nat. Struct. Biol. 6, 72-79
27. Ludwigs, U., Elgavish, A., Esko, J. D., Meezan, E., and Rodén, L. (1987) Biochem. J. 245, 795-804
28. Vranken, W. F., Boucher, W., Stevens, T. J., Fogh, R. H., Pajon, A., Llinas, M., Ulrich, E., Markley, J. L., Ionides, J., and Laue, E. D. (2005) Proteins 59, 687-696
29. Jin, L., Barran, P. E., Deakin, J. A., Lyon, M., and Uhrín, D. (2005) Phys. Chem. Chem. Phys. 7, 3464-3471
30. Deakin, J. A., and Lyon, M. (2008) Glycobiology 18, 483-491
31. Esko, J. D., Stewart, T. E., and Taylor, W. H. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 3197-3201
32. Thunberg, L., Bäckström, G., and Lindahl, U. (1982) Carbohydr. Res. 100, 393-410
33. Mahoney, D. J., Mulloy, B., Forster, M. J., Blundell, C. D., Fries, E., Milner, C. M., and Day, A. J. (2005) J. Biol. Chem. 280, 27044-27055
34. Harris, E. N., and Weigel, P. H. (2008) Glycobiology 18, 638-648
35. Higman, V. A., Blundell, C. D., Mahoney, D. J., Redfield, C., Noble, M. E. M., and Day, A. J. (2007) J. Mol. Biol. 271, 669-684
36. Zhou, H. J., Casas-Finet, J. R., Coats, R. H., Kaufman, J. D., Stahl, S. J., Wingfield, P. T., Rubin, J. S., Bottaro, D. P., and Byrd, R. A. (1999) Biochemistry 38, 14793-14802
37. Casu, B., Petitou, M., Provasoli, M., and Sinaÿ, P. (1988) Trends Biochem. Sci. 13, 221-225
38. Mulloy, B., and Forster, M. J. (2000) Glycobiology 10, 1147-1156
39. Raman, R., Venkataraman, G., Ernst, S., Sasisekharan, V., and Sasisekharan, R. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2357-2362
40. Bullock, S. L., Fletcher, J. M., Beddington, R. S., and Wilson, V. A. (1998) Genes Dev. 12, 1894-1906
41. Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A., and Birchmeier, C. (1995) Nature 376, 768-771
42. Schmidt, C., Bladt, F., Goedecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M., Gherardi, E., and Birchmeier, C. (1995) Nature 373, 699-702
43. Uehara, Y., Minowa, O., Mori, C., Shiota, K., Kuno, J., Noda, T., and Kitamura, N. (1995) Nature 373, 702-705
44. Merry, C. L. R., Bullock, S. L., Swan, D. C., Backen, A. C., Lyon, M., Beddington, R. S. P., Wilson, V. A., and Gallagher, J. T. (2001) J. Biol. Chem. 276, 35429-35434
45. Lai, J. P., Chien, J. R., Strome, S. E., Staub, J. K., Montoya, D. P., Greene, E. L., Smith, D. I., Roberts, L. R., and Shridhar, V. (2004) Oncogene 23, 1439-1447
46. Lai, J. P., Chien, J. R., Moser, D. R., Staub, J. K., Aderca, I., Montoya, D. P., Matthews, T. A., Nagorney, D. M., Cunningham, J. M., Smith, D. I., Greene, E. L., Shridhar, V., and Roberts, L. R. (2004) Gastroenterology 126, 231-248
47. Viviano, B. L., Paine-Saunders, S., Gasiunas, N., Gallagher, J., and Saunders, S. (2004) J. Biol. Chem. 279, 5604-5611
48. Ai, X., Do, A.-T., Kusche-Gullberg, M., Lindahl, U., Lu, K., and Emerson, C. P. (2005) J. Biol. Chem. 281, 4969-4976
49. Tolbert, W. D., Daugherty, J., Gao, C. F., Xie, Q., Miranti, C., Gherardi, E., Vande Woude, G., and Xu, H. E. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 14592-14597
50. Gherardi, E., Sandin, S., Petoukhov, M. V., Finch, J., Youles, M. E., Öfverstedt, L.-G., Miguel, R. N., Blundell, T. L., Vande Woude, G. F., Skoglund, U., and Svergun, D. I. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 4046-4051
51. Goodger, S. J., Robinson, C. J., Murphy, K. J., Gasiunas, N., Harmer, N. J., Goodger, S. J., Robinson, C. J., Murphy, K. J., Gasiunas, N., Harmer, N. J., Blundell, T. L., Pye, D. A., and Gallagher, J. T. (2008) J. Biol. Chem. 283, 13001-13008