Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6321-6325

  Raiber, Eun Ang ^a   Wilkinson, James A ^a   Manetti, Fabrizio ^c   Botta, Maurizio ^c   Deakin, Jon ^b   Gallagher, John ^b   Lyon, Malcolm ^b   Ducki, Sylvie W ^a  

^a UNIVERSITY OF SALFORD   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

Glycosaminoglycan (GAG); Heparin heparan sulfate (H HS); Hepatocyte growth factor scatter factor (HGF SF); Non carbohydrate mimic; Tyrosine kinase receptor MET

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; GLYCOSAMINOGLYCAN; HEPARIN; MITOGEN ACTIVATED PROTEIN KINASE; SCATTER FACTOR; SCATTER FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CHO CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RECEPTOR UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL LINE; CELL MOVEMENT; COMPUTER SIMULATION; DOGS; HEPARIN; HEPARITIN SULFATE; HEPATOCYTE GROWTH FACTOR; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS; RECEPTORS, GROWTH FACTOR;

EID: 35148855038     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.074     Document Type: Article

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