Understanding the mechanism of drug resistance due to a codon deletion in protoporphyrinogen oxidase through computational modeling

Journal of Physical Chemistry B

Volumn 113, Issue 14, 2009, Pages 4865-4875

  Hao, Ge Fei ^a,b   Zhu, Xiao Lei ^a,b   Ji, Feng Qin ^a,b   Zhang, Li ^a,b   Yang, Guang Fu ^a,b   Zhan, Chang Guo ^a,b,c  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

^b University of Kentucky   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROPHYLL; DYNAMICS; HERBICIDES; HYDROGEN; HYDROGEN BONDS; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PORPHYRINS; REACTION KINETICS;

AGRICULTURAL FIELDS; BINDING POCKETS; COMPUTATIONAL MODELING; COMPUTATIONAL MODELS; COMPUTATIONAL SIMULATIONS; CONFORMATIONAL CHANGES; DIRECT INTERACTIONS; DRUG RESISTANCES; ENZYMATIC TRANSFORMATIONS; HOMOLOGY MODELING; HYDROGEN-BONDING NETWORKS; INTERCHAIN HYDROGEN BONDS; MOLECULAR MECHANISMS; MOLECULAR-DYNAMICS SIMULATIONS; POISSON-BOLTZMANN; PROTOPORPHYRIN-IX; PROTOPORPHYRINOGEN OXIDASE; RATIONAL DESIGNS; SURFACE AREAS; WILD TYPES; WILD-TYPE ENZYMES;

ENZYMES;

EID: 65249103492     PISSN: 15206106     EISSN: None     Source Type: Journal    
DOI: 10.1021/jp807442n     Document Type: Article

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