Effects of new 5-amino-1,3,4-thiadiazole-2-sulfonamide derivatives on human carbonic anhydrase isozymes

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 9, 2009, Pages 3295-3301

  Kasimoǧullari, Rahmi ^a   Bülbül, Metin ^a   Günhan, Hatice ^a   Güleryüz, Hülya ^a  

^a DUMLUPINAR UNIVERSITY   (Turkey)

Author keywords

Carbonic anhydrase; Hydratase and esterase activities; IC50 value; Pyrazole carboxylic acids; Sulfonamide

Indexed keywords

1 (3 AMINOPHENYL) 4 BENZOYL 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOLE 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 (4 AMINOPHENYL) 4 BENZOYL 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOLE 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 BENZOYL 1 (2 METHYL 1 (2 OXOPROPYL) 1H INDOL 4 YL) 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 BENZOYL 1 (3 ((1,3 DIOXO 1,3 DIPHENYLPROPAN 2 YL)DIAZENYL)PHENYL) 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 BENZOYL 1 (3 ((2 HYDROXYNAPHTHALEN 1 YL)DIAZENYL)PHENYL) 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 BENZOYL 1 (3 ((2,4 DIOXOPENTAN 3 YL)DIAZENYL)PHENYL) 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 BENZOYL 1 (3 ((4 HYDROXYPHENYL)DIAZENYL)PHENYL) 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 BENZOYL 1 (3 (2 (1,3 DIOXO 1 PHENYLBUTAN 2 YLIDENE)HYDRAZINYL)PHENYL) 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 BENZOYL 1 (3 CYANOPHENYL) 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 BENZOYL 1 (3 HYDROXYPHENYL) 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 BENZOYL 1 (3 IODOPHENYL) 5 PHENYL N (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YL) 1H PYRAZOLE 3 CARBOXAMIDE; 5 AMINO 1,3,4 THIADIAZOLE 2 SULFONAMIDE DERIVATIVE; ACETAZOLAMIDE; ANTIGLAUCOMA AGENT; BUTYL2 ((3 (4 BENZOYL 5 PHENYL 3 (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YLCARBAMOYL) 1H PYRAZOL 1 YL)PHENYL)DIAZENYL) 3 OXOBUTANOATE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; DIETHYL 2 ((3 (4 BENZOYL 5 PHENYL 3 (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YLCARBAMOYL) 1H PYRAZOL 1 YL)PHENYL)DIAZENYL)MALONATE; ESTERASE; ETHYL 1 (3 AMINOPHENYL) 5 PHENYL 3 (5 SULFAMOYL 1,3,4 THIADIAZOLE 2 YLCARBAMOYL) 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 1 (4 AMINOPHENYL) 5 PHENYL 3 (5 SULFAMOYL 1,3,4 THIADIAZOLE 2 YLCARBAMOYL) 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 2 ((3 (4 BENZOYL 5 PHENYL 3 (5 SULFAMOYL 1,3,4 THIADIAZOL 2 YLCARBAMOYL) 1H PYRAZOL 1 YL)PHENYL)DIAZENYL) 3 OXO 3 PHENYLPROPANOATE; HYDROLYASE; SULFONAMIDE; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ARTICLE; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME PURIFICATION; ERYTHROCYTE MEMBRANE; IC 50;

CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; ENZYME INHIBITORS; ERYTHROCYTES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; SUBSTRATE SPECIFICITY; SULFONAMIDES; THIADIAZOLES;

EID: 65249093770     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.048     Document Type: Article

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