Defining dose-response relationships in the therapeutic blockade of B7RP-1-dependent immune responses

European Journal of Pharmacology

Volumn 610, Issue 1-3, 2009, Pages 110-118

  Metz, Daniela P ^a   Mohn, Deanna ^a   Zhang, Ming ^a   Horan, Tom ^a   Kim, Helen ^a   Deshpande, Rohini ^a   Jacobsen, Frederick ^a   Shen, Wenyan D ^a   Zhang, Liana ^a   Doellgast, George ^a   Narayanan, Adimoolam ^a   Dalphin, Mark ^a   Kuchimanchi, Kameswara Rao V ^a   Horner, Michelle ^a   Chung, James ^a   Siu, Gerald ^a  

^a AMGEN INC   (United States)

Author keywords

1B7v2; B7RP 1; Costimulation; Humoral immune response; ICOS; Keyhole limpet hemocyanin (KLH); Target occupancy assay

Indexed keywords

B7 RELATED PROTEIN 1; INDUCIBLE T CELL CO STIMULATOR PROTEIN; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1B7; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG TARGETING; FEMALE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SINGLE DRUG DOSE; T LYMPHOCYTE;

ALUMINUM HYDROXIDE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD19; ANTIGENS, CD3; ANTIGENS, CD80; B-LYMPHOCYTES; BINDING SITES; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HEMOCYANIN; IMMUNE SYSTEM PROCESSES; MICE; MICE, INBRED BALB C; MODELS, IMMUNOLOGICAL; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TEMPERATURE; TIME FACTORS;

EID: 65049085223     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.03.023     Document Type: Article

References (25)

1. Akbari O., Freeman G.J., Meyer E.H., Greenfield E.A., Chang T.T., Sharpe A.H., Berry G., Bekruyff R.H., and Umetsu D.T. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. 8 (2002) 1024-1032
2. Appleman L.J., and Boussiotis V.A. T cell anergy and costimulation. Immunol. Rev. 192 (1992) 161-180
3. Bachmann M.F., Zinkernagel R.M., and Oxenius A. Immune responses in the absence of costimulation: viruses know the trick. J. Immunol. 161 (1998) 5791-5794
4. Coyle A.J., Lehar S., Lloyd C., Tian J., Delaney T., Manning S., Nguyen T., Burwell T., Schneider H., Gonzalo J.A., Gosselin M., Owen L.R., Rudd C.E., and Gutierrez-Ramos J.C. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13 (2000) 95-105
5. Dong C., Juedes A.E., Temann U.A., Shresta S., Allison J.P., Ruddle N.H., and Flavell R.A. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409 (2001) 97-101
6. Gonzalo J.A., Tian J., Delaney T., Corcoran J., Rottman J.B., Lora J., Al Garawi A., Kroczek R., Gutierrez-Ramos J.C., and Coyle A.J. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat. Immunol. 2 (2001) 597-604
7. Greenwald R.J., McAdam A.J., Van Der W.D., Satoskar A.R., and Sharpe A.H. Inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis. J. Immunol. 168 (2002) 991-995
8. Grimbacher B., Hutloff A., Schlesier M., Glocker E., Warnatz K., Drager R., Eibel H., Fischer B., Schaffer A.A., Mages H.W., Kroczek R.A., and Peter H.H. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat. Immunol. 4 (2003) 261-268
9. Grimbacher B., Warnatz K., and Peter H.H. The immunological synapse for B-cell memory: the role of the ICOS and its ligand for the longevity of humoral immunity. Curr. Opin. Allergy Clin. Immunol. 3 (2003) 409-419
10. Iwai H., Kozono Y., Hirose S., Akiba H., Yagita H., Okumura K., Kohsaka H., Miyasaka N., and Azuma M. Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. J. Immunol. 169 (2002) 4332-4339
11. Iwai H., Abe M., Hirose S., Tsushima F., Tezuka K., Akiba H., Yagita H., Okumura K., Kohsaka H., Miyasaka N., and Azuma M. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J. Immunol. 171 (2003) 2848-2854
12. Ling V., Wu P.W., Finnerty H.F., Bean K.M., Spaulding V., Fouser L.A., Leonard J.P., Hunter S.E., Zollner R., Thomas J.L., Miyashiro J.S., Jacobs K.A., and Collins M. Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J. Immunol. 164 (2000) 653-657
13. Mak T.W., Shahinian A., Yoshinaga S.K., Wakeham A., Boucher L.M., Pintilie M., Duncan G., Gajewska B.U., Gronski M., Eriksson U., Odermatt B., Ho A., Bouchard D., Whorisky J.S., Jordana M., Ohashi P.S., Pawson T., Bladt F., and Tafuri A. Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat. Immunol. 4 (2003) 765-772
14. McAdam A.J., Greenwald R.J., Levin M.A., Chernova T., Malenkovich N., Ling V., Freeman G.J., and Sharpe A.H. ICOS is critical for CD40-mediated antibody class switching. Nature 409 (2001) 102-105
15. Nurieva R.I., Mai X.M., Forbush K., Bevan M.J., and Dong C. B7h is required for T cell activation, differentiation, and effector function. Proc. Natl. Acad. Sci. 100 (2003) 14163-14168
16. Nurieva R.I., Treuting P., Duong J., Flavell R.A., and Dong C. Inducible costimulator is essential for collagen-induced arthritis. J. Clin. Invest. 111 (2003) 701-706
17. Ozkaynak E., Gao W., Shemmeri N., Wang C., Gutierrez-Ramos J.C., Amaral J., Qin S., Rottman J.B., Coyle A.J., and Hancock W.W. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat. Immunol. 2 (2001) 591-606
18. Rottman J.B., Smith T., Tonra J.R., Ganley K., Bloom T., Silva R., Pierce B., Gutierrez-Ramos J.C., Ozkaynak E., and Coyle A.J. The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat. Immunol. 2 (2001) 605-611
19. Sporici R.A., and Perrin P.J. Costimulation of memory T-cells by ICOS: a potential therapeutic target for autoimmunity?. Clin. Immunol. 100 (2001) 263-269
20. Swallow M.M., Wallin J.J., and Sha W.C. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity 11 (1999) 423-432
21. Tafuri A., Shahinian A., Bladt F., Yoshinaga S.K., Jordana M., Wakeham A., Boucher L.M., Bouchard D., Chan V.S., Duncan G., Odermatt B., Ho A., Itie A., Horan T., Whoriskey J.S., Pawson T., Penninger J.M., Ohashi P.S., and Mak T.W. ICOS is essential for effective T-helper-cell responses. Nature 409 (2001) 105-109
22. Tamada K., and Chen L. T lymphocyte costimulatory molecules in host defense and immunologic diseases. Ann. Allergy, Asthma, & Immun. 85 (2000) 164-175
23. Tesciuba A.G., Subudhi S., Rother R.P., Faas S.J., Frantz A.M., Elliot D., Weinstock J., Matis L.A., Bluestone J.A., and Sperling A.I. Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease. J. Immunol. 167 (2001) 1996-2003
24. Yoshinaga S.K., Whoriskey J.S., Khare S.D., Sarmiento U., Guo J., Horan T., Shih G., Zhang M., Coccia M.A., Kohno T., Tafuri-Bladt A., Brankow D., Campbell P., Chang D., Chiu L., Dai T., Duncan G., Elliott G.S., Hui A., Mccabe S.M., Scully S., Shahinian A., Shaklee C.L., Van G., Mak T.W., and Senaldi G. T-cell co-stimulation through B7RP-1 and ICOS. Nature 402 (1999) 827-832
25. Watanabe M., Takagi Y., Kotani M., Hara Y., Inamine A., Hayashi K., Ogawa S., Takeda K., Tanabe K., and Abe R. Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J. Immunol. 180 (2008) 5222-5234