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Volumn 29, Issue 4, 2009, Pages 1367-1372

siRNA targeting HIF-lα induces apoptosis of pancreatic cancer cells through NF-κB-independent and -dependent pathways under hypoxic conditions

Author keywords

Apoptosis; Hypoxia inducible factor (hif); Nuclear factor kappab (nf kappa; b); Proliferation; Recombinant adeno associated virus (raav); Small interference rna (sirna)

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PARVOVIRUS VECTOR; SMALL INTERFERING RNA;

EID: 64949171489     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (23)

References (24)
  • 1
    • 34447331032 scopus 로고    scopus 로고
    • Expression of Snail in pancreatic cancer promotes metastasis and chemoresistance
    • Yin T, Wang C, Liu T et al: Expression of Snail in pancreatic cancer promotes metastasis and chemoresistance. J Surg Res 141: 196-203, 2007.
    • (2007) J Surg Res , vol.141 , pp. 196-203
    • Yin, T.1    Wang, C.2    Liu, T.3
  • 2
    • 0030022252 scopus 로고    scopus 로고
    • Tumor oxygenation predicts for the likelihood of distant metastasis in human soft tissue sarcoma
    • Brizel DM, Scully SP, Harrelson JM et al: Tumor oxygenation predicts for the likelihood of distant metastasis in human soft tissue sarcoma. Cancer Research 56: 941-943, 1996.
    • (1996) Cancer Research , vol.56 , pp. 941-943
    • Brizel, D.M.1    Scully, S.P.2    Harrelson, J.M.3
  • 3
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL: Targeting HIF-1 for cancer therapy. Nature Rev 3: 721-732, 2003.
    • (2003) Nature Rev , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 5
    • 0035903468 scopus 로고    scopus 로고
    • Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
    • Masson N, Willam C, Maxwell PH et al: Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J 20: 5197-5206, 2001.
    • (2001) EMBO J , vol.20 , pp. 5197-5206
    • Masson, N.1    Willam, C.2    Maxwell, P.H.3
  • 6
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL: HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474- 1480, 2000.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 7
    • 0032493368 scopus 로고    scopus 로고
    • 2-dependent degradation domain via the ubiquitin-proteasome pathway
    • 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95: 7987-7992, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3
  • 8
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang BH, Rue E, Wang GL et al: Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271: 17771-17778, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3
  • 9
    • 0037215306 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer
    • Buchler P, Reber HA, Büchler M et al: Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas 26: 56-64, 2003.
    • (2003) Pancreas , vol.26 , pp. 56-64
    • Buchler, P.1    Reber, H.A.2    Büchler, M.3
  • 10
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • Huasheng Lu, Robert A, Forbes et al: Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. Bio Chem 26: 23111-23115, 2002.
    • (2002) Bio Chem , vol.26 , pp. 23111-23115
    • Lu, H.1    Robert, A.2    Forbes3
  • 11
    • 33947498749 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 mediates effects of insulin on pancreatic cancer cells and disturbs host energy homeostasis
    • Wang F, Li SS, Segersvard R et al: Hypoxia inducible factor-1 mediates effects of insulin on pancreatic cancer cells and disturbs host energy homeostasis. Am J Pathol 170: 469-477, 2007.
    • (2007) Am J Pathol , vol.170 , pp. 469-477
    • Wang, F.1    Li, S.S.2    Segersvard, R.3
  • 12
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor-la in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E et al: Overexpression of hypoxia-inducible factor-la in common human cancers and their metastases. Cancer Res 59: 5830-5835, 1999.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 13
    • 0344858928 scopus 로고    scopus 로고
    • Apoptosis: Targets in pancreatic cancer
    • Westphal S and kalthoff H: Apoptosis: targets in pancreatic cancer. Mol Cancer 2: 6, 2003.
    • (2003) Mol Cancer , vol.2 , pp. 6
    • Westphal, S.1    kalthoff, H.2
  • 14
    • 33745298519 scopus 로고    scopus 로고
    • karin M: Nuclear factor-kappaB in cancer development and progression. Nature 441: 431-436, 2006.
    • karin M: Nuclear factor-kappaB in cancer development and progression. Nature 441: 431-436, 2006.
  • 15
    • 33645999706 scopus 로고    scopus 로고
    • NF-kappaB and Ikk; as therapeutic targets in cancer
    • kim HJ, Hawke N and Baldwin AS: NF-kappaB and Ikk; as therapeutic targets in cancer. Cell Death Differ 13: 738-747, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 738-747
    • kim, H.J.1    Hawke, N.2    Baldwin, A.S.3
  • 16
    • 11844301338 scopus 로고    scopus 로고
    • Cell death pathways in pancreatitis and pancreatic cancer
    • Gukovskaya AS and Pandol SJ: Cell death pathways in pancreatitis and pancreatic cancer. Pancreatology 4: 567-586, 2004.
    • (2004) Pancreatology , vol.4 , pp. 567-586
    • Gukovskaya, A.S.1    Pandol, S.J.2
  • 17
    • 7644223910 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis
    • Li L, Aggarwal BB, Shishodia S et al: Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 101: 2351-2362, 2004.
    • (2004) Cancer , vol.101 , pp. 2351-2362
    • Li, L.1    Aggarwal, B.B.2    Shishodia, S.3
  • 18
    • 33749260717 scopus 로고    scopus 로고
    • Deregulated NF-kappaB activity in haematological malignancies
    • keutgens A, Robert I, Viatour P et at Deregulated NF-kappaB activity in haematological malignancies. Biochem Pharmacol 72: 1069-1080, 2006.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1069-1080
    • keutgens, A.1    Robert, I.2    Viatour, P.3    et at4
  • 19
    • 23044479821 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces Gl/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma
    • Shishodia S, Amin HM, Lai R et al: Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces Gl/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 70: 700-713, 2005.
    • (2005) Biochem Pharmacol , vol.70 , pp. 700-713
    • Shishodia, S.1    Amin, H.M.2    Lai, R.3
  • 20
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-lalpha
    • Rius J, Guma M, Schachtrup C et al: NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-lalpha. Nature 453: 807-811, 2008.
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3
  • 21
    • 0034877670 scopus 로고    scopus 로고
    • RNA interference: Listening to the sound of silence
    • Zamore PD: RNA interference: listening to the sound of silence. Nat Struct Biol 8: 746-750, 2001.
    • (2001) Nat Struct Biol , vol.8 , pp. 746-750
    • Zamore, P.D.1
  • 22
    • 0042838272 scopus 로고    scopus 로고
    • Use of adeno- associated viral vector for delivery of small interfering RNA
    • Tomar RS, Matta H and Chaudhary PM: Use of adeno- associated viral vector for delivery of small interfering RNA. Oncogene 22: 5712-5715, 2003.
    • (2003) Oncogene , vol.22 , pp. 5712-5715
    • Tomar, R.S.1    Matta, H.2    Chaudhary, P.M.3
  • 23
    • 0037228848 scopus 로고    scopus 로고
    • Adeno-associated virus vectors for therapeutic gene transfer
    • Stilwell JL and Samulsκi RJ: Adeno-associated virus vectors for therapeutic gene transfer. Biotechniques 34: 148-150, 2003.
    • (2003) Biotechniques , vol.34 , pp. 148-150
    • Stilwell, J.L.1    Samulsκi, R.J.2
  • 24
    • 0035003230 scopus 로고    scopus 로고
    • A novel method for purification of recombinant adeno-associated virus vectors on a large scale
    • Wu XB, Dong XY, Wu ZJ et al: A novel method for purification of recombinant adeno-associated virus vectors on a large scale. Chin Sci Bull 46: 485-489, 2001.
    • (2001) Chin Sci Bull , vol.46 , pp. 485-489
    • Wu, X.B.1    Dong, X.Y.2    Wu, Z.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.