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Volumn 101, Issue 4, 2009, Pages 635-642

Myocardial protection against reperfusion injury: The cGMP pathway

Author keywords

Acute myocardial infarction; Ischaemic heart disease; Platelet physiology

Indexed keywords

ADENOSINE TRIPHOSPHATE; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CALCIUM; CYCLIC GMP; URODILATIN;

EID: 64849095173     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH08-11-0764     Document Type: Conference Paper
Times cited : (48)

References (94)
  • 1
    • 0026499874 scopus 로고
    • Selective inhibition of the contractile apparatus. A new approach to modification of infarct size, infarct composition, and infarct geometry during coronary artery occlusion and reperfusion
    • Garcia-Dorado D, Théroux P, Duran JM, et al. Selective inhibition of the contractile apparatus. A new approach to modification of infarct size, infarct composition, and infarct geometry during coronary artery occlusion and reperfusion. Circulation 1992; 85: 1160-1174.
    • (1992) Circulation , vol.85 , pp. 1160-1174
    • Garcia-Dorado, D.1    Théroux, P.2    Duran, J.M.3
  • 2
    • 0026002814 scopus 로고
    • Influence of perfusate pH on the postischaemic recovery of cardiac contractile function: Involvement of sodium-hydrogen exchange
    • Meng H P, Lonsberry BB, Pierce GN. Influence of perfusate pH on the postischaemic recovery of cardiac contractile function: involvement of sodium-hydrogen exchange. J Pharmacol Exp Ther 1991; 258: 772-777.
    • (1991) J Pharmacol Exp Ther , vol.258 , pp. 772-777
    • Meng, H.P.1    Lonsberry, B.B.2    Pierce, G.N.3
  • 3
    • 0034934941 scopus 로고    scopus 로고
    • Role of the reverse mode of the Na+/Ca2+ exchanger in reoxygenation-induced cardiomyocyte injury
    • Schäfer C, Ladilov Y, Inserte J, et al. Role of the reverse mode of the Na+/Ca2+ exchanger in reoxygenation-induced cardiomyocyte injury. Cardiovasc Res 2001; 51: 241-250.
    • (2001) Cardiovasc Res , vol.51 , pp. 241-250
    • Schäfer, C.1    Ladilov, Y.2    Inserte, J.3
  • 4
    • 0032516296 scopus 로고    scopus 로고
    • Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group
    • Goldstein I, Lue T F, Padma-Nathan H, et al. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med 1998; 338: 1397-1404.
    • (1998) N Engl J Med , vol.338 , pp. 1397-1404
    • Goldstein, I.1    Lue, T.F.2    Padma-Nathan, H.3
  • 5
    • 0023258463 scopus 로고
    • Effects of atrial natriuretic factor on natriuresis and cGMP in patients with essential hypertension
    • Cusson JR, Hamet P, Gutkowska J, et al. Effects of atrial natriuretic factor on natriuresis and cGMP in patients with essential hypertension. J Hypertens 1987; 5: 435-443.
    • (1987) J Hypertens , vol.5 , pp. 435-443
    • Cusson, J.R.1    Hamet, P.2    Gutkowska, J.3
  • 6
    • 0023014083 scopus 로고
    • Energy dependence of contraction band formation in perfused hearts and isolated adult myocytes
    • Vander Heide RS, Angelo J P, Altschuld RA, et al. Energy dependence of contraction band formation in perfused hearts and isolated adult myocytes. Am J Pathol 1986; 125: 55-68.
    • (1986) Am J Pathol , vol.125 , pp. 55-68
    • Vander Heide, R.S.1    Angelo, J.P.2    Altschuld, R.A.3
  • 8
    • 0029881675 scopus 로고    scopus 로고
    • Myocardial segment shrinkage during coronary reperfusion in situ. Relation to hypercontracture and myocardial necrosis
    • Barrabés JA, Garcia-Dorado D, Ruiz-Meana M, et al. Myocardial segment shrinkage during coronary reperfusion in situ. Relation to hypercontracture and myocardial necrosis. Pflugers Arch 1996; 431: 519-526.
    • (1996) Pflugers Arch , vol.431 , pp. 519-526
    • Barrabés, J.A.1    Garcia-Dorado, D.2    Ruiz-Meana, M.3
  • 9
    • 0036054213 scopus 로고    scopus 로고
    • Effect of inhibition of Na(+)/Ca(2+) exchanger at the time of myocardial reperfusion on hypercontracture and cell death
    • Inserte J, Garcia-Dorado D, Ruiz-Meana M, et al. Effect of inhibition of Na(+)/Ca(2+) exchanger at the time of myocardial reperfusion on hypercontracture and cell death. Cardiovasc Res 2002; 55: 739-748.
    • (2002) Cardiovasc Res , vol.55 , pp. 739-748
    • Inserte, J.1    Garcia-Dorado, D.2    Ruiz-Meana, M.3
  • 10
    • 0031441147 scopus 로고    scopus 로고
    • Halothane protects cardiomyocytes against reoxygenationinduced hypercontracture
    • Siegmund B, Schlack W, Ladilov Y V, et al. Halothane protects cardiomyocytes against reoxygenationinduced hypercontracture. Circulation 1997; 96: 4372-4379.
    • (1997) Circulation , vol.96 , pp. 4372-4379
    • Siegmund, B.1    Schlack, W.2    Ladilov, Y.V.3
  • 11
    • 20144366555 scopus 로고    scopus 로고
    • Mechanism of cGMP-mediated protection in a cellular model of myocardial reperfusion injury
    • Abdallah Y, Gkatzoflia A, Pieper H, et al. Mechanism of cGMP-mediated protection in a cellular model of myocardial reperfusion injury. Cardiovasc Res 2005; 66: 123-131.
    • (2005) Cardiovasc Res , vol.66 , pp. 123-131
    • Abdallah, Y.1    Gkatzoflia, A.2    Pieper, H.3
  • 12
    • 0029091597 scopus 로고
    • Effect of osmotic stress on sarcolemmal integrity of isolated cardiomyocytes following transient metabolic inhibition
    • Ruiz-Meana M, García-Dorado D, González MA, et al. Effect of osmotic stress on sarcolemmal integrity of isolated cardiomyocytes following transient metabolic inhibition. Cardiovasc Res 1995; 30: 64-69.
    • (1995) Cardiovasc Res , vol.30 , pp. 64-69
    • Ruiz-Meana, M.1    García-Dorado, D.2    González, M.A.3
  • 13
    • 24744445376 scopus 로고    scopus 로고
    • Calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion contributes to cell death after myocardial ischaemia
    • Inserte J, Garcia-Dorado D, Hernando V, et al. Calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion contributes to cell death after myocardial ischaemia. Circ Res 2005; 97: 465-473.
    • (2005) Circ Res , vol.97 , pp. 465-473
    • Inserte, J.1    Garcia-Dorado, D.2    Hernando, V.3
  • 14
    • 33748283943 scopus 로고    scopus 로고
    • Ischaemic preconditioning prevents calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion
    • Inserte J, Garcia-Dorado D, Hernando V, et al. Ischaemic preconditioning prevents calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion. Cardiovasc Res 2006; 70: 364-373.
    • (2006) Cardiovasc Res , vol.70 , pp. 364-373
    • Inserte, J.1    Garcia-Dorado, D.2    Hernando, V.3
  • 15
    • 4444303977 scopus 로고    scopus 로고
    • Ischaemic preconditioning attenuates calpain-mediated degradation of structural proteins through a protein kinase A-dependent mechanism
    • Inserte J, Garcia-Dorado D, Ruiz-Meana M, et al. Ischaemic preconditioning attenuates calpain-mediated degradation of structural proteins through a protein kinase A-dependent mechanism. Cardiovasc Res 2004; 64: 105-114.
    • (2004) Cardiovasc Res , vol.64 , pp. 105-114
    • Inserte, J.1    Garcia-Dorado, D.2    Ruiz-Meana, M.3
  • 16
    • 17144439067 scopus 로고
    • Favorable effects of hyperosmotic reperfusion on myocardial edema and infarct size
    • Garcia-Dorado D, Théroux P, Munoz R, et al. Favorable effects of hyperosmotic reperfusion on myocardial edema and infarct size. Am J Physiol 1992; 262: H17-22.
    • (1992) Am J Physiol , vol.262
    • Garcia-Dorado, D.1    Théroux, P.2    Munoz, R.3
  • 17
    • 0033529651 scopus 로고    scopus 로고
    • Propagation of cardiomyocyte hypercontracture by passage of Na(+) through gap junctions
    • Ruiz-Meana M, Garcia-Dorado D, Hofstaetter B, et al. Propagation of cardiomyocyte hypercontracture by passage of Na(+) through gap junctions. Circ Res 1999; 85: 280-287.
    • (1999) Circ Res , vol.85 , pp. 280-287
    • Ruiz-Meana, M.1    Garcia-Dorado, D.2    Hofstaetter, B.3
  • 18
    • 0030780568 scopus 로고    scopus 로고
    • Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion
    • Garcia-Dorado D, Inserte J, Ruiz-Meana M, et al. Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion. Circulation 1997; 96: 3579-3586.
    • (1997) Circulation , vol.96 , pp. 3579-3586
    • Garcia-Dorado, D.1    Inserte, J.2    Ruiz-Meana, M.3
  • 19
    • 4444254148 scopus 로고    scopus 로고
    • Enhanced effect of gap junction uncouplers on macroscopic electrical properties of reperfused myocardium
    • Rodriguez-Sinovas A, García-Dorado D, Ruiz- Meana M, et al. Enhanced effect of gap junction uncouplers on macroscopic electrical properties of reperfused myocardium. J Physiol 2004; 559: 245-257.
    • (2004) J Physiol , vol.559 , pp. 245-257
    • Rodriguez-Sinovas, A.1    García-Dorado, D.2    Ruiz- Meana, M.3
  • 20
    • 0027381281 scopus 로고
    • On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury
    • Duchen MR, McGuinness O, Brown LA, et al. On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury. Cardiovasc Res 1993; 27: 1790-1794.
    • (1993) Cardiovasc Res , vol.27 , pp. 1790-1794
    • Duchen, M.R.1    McGuinness, O.2    Brown, L.A.3
  • 21
    • 0028968606 scopus 로고
    • Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion
    • Griffiths EJ, Halestrap A P. Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J 1995; 307: 93-98.
    • (1995) Biochem J , vol.307 , pp. 93-98
    • Griffiths, E.J.1    Halestrap, A.P.2
  • 22
    • 0035951823 scopus 로고    scopus 로고
    • Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischaemic reperfusion of the heart
    • Di Lisa F, Menabo R, Canton M, et al. Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischaemic reperfusion of the heart. J Biol Chem 2001; 276: 2571-2575.
    • (2001) J Biol Chem , vol.276 , pp. 2571-2575
    • Di Lisa, F.1    Menabo, R.2    Canton, M.3
  • 23
    • 0041810128 scopus 로고    scopus 로고
    • The adenine nucleotide translocase: A central component of the mitochondrial permeability transition pore and key player in cell death
    • Halestrap A P, Brennerb C. The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. Curr Med Chem 2003; 10: 1507-1525.
    • (2003) Curr Med Chem , vol.10 , pp. 1507-1525
    • Halestrap, A.P.1    Brennerb, C.2
  • 24
    • 23744471140 scopus 로고    scopus 로고
    • Mitochondria and ischaemia/reperfusion injury
    • Honda HM, Korge P, Weiss JN. Mitochondria and ischaemia/reperfusion injury. Ann N Y Acad Sci 2005; 1047: 248-258.
    • (2005) Ann N Y Acad Sci , vol.1047 , pp. 248-258
    • Honda, H.M.1    Korge, P.2    Weiss, J.N.3
  • 25
    • 35348834146 scopus 로고    scopus 로고
    • Opening of mitochondrial permeability transition pore induces hypercontracture in Ca2+ overloaded cardiac myocytes
    • Ruiz-Meana M, Abellán A, Miró-Casas E, et al. Opening of mitochondrial permeability transition pore induces hypercontracture in Ca2+ overloaded cardiac myocytes. Basic Res Cardiol 2007; 102: 542-552.
    • (2007) Basic Res Cardiol , vol.102 , pp. 542-552
    • Ruiz-Meana, M.1    Abellán, A.2    Miró-Casas, E.3
  • 26
    • 9444272762 scopus 로고    scopus 로고
    • Intimal injury in a transiently occluded coronary artery increases myocardial necrosis. Effect of aspirin
    • Barrabés JA, Garcia-Dorado D, Oliveras J, et al. Intimal injury in a transiently occluded coronary artery increases myocardial necrosis. Effect of aspirin. Pflugers Arch 1996; 432: 663-670.
    • (1996) Pflugers Arch , vol.432 , pp. 663-670
    • Barrabés, J.A.1    Garcia-Dorado, D.2    Oliveras, J.3
  • 27
    • 0033899947 scopus 로고    scopus 로고
    • Dynamic intracoronary thrombosis does not cause significant downstream platelet embolization
    • Barrabés JA, Garcia-Dorado D, Soriano B, et al. Dynamic intracoronary thrombosis does not cause significant downstream platelet embolization. Cardiovasc Res 2000; 47: 265-273.
    • (2000) Cardiovasc Res , vol.47 , pp. 265-273
    • Barrabés, J.A.1    Garcia-Dorado, D.2    Soriano, B.3
  • 28
    • 19944428340 scopus 로고    scopus 로고
    • Antagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischaemia
    • Barrabés JA, Garcia-Dorado D, Mirabet M, et al. Antagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischaemia. J Am Coll Cardiol 2005; 45: 293-299.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 293-299
    • Barrabés, J.A.1    Garcia-Dorado, D.2    Mirabet, M.3
  • 29
    • 22244454371 scopus 로고    scopus 로고
    • Thrombin increases cardiomyocyte acute cell death after ischaemia and reperfusion
    • Mirabet M, Garcia-Dorado D, Ruiz-Meana M, et al. Thrombin increases cardiomyocyte acute cell death after ischaemia and reperfusion. J Mol Cell Cardiol 2005; 39: 277-283.
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 277-283
    • Mirabet, M.1    Garcia-Dorado, D.2    Ruiz-Meana, M.3
  • 30
    • 36348940962 scopus 로고    scopus 로고
    • Platelet deposition in remote cardiac regions after coronary occlusion
    • Barrabés JA, Mirabet M, Agulló L, et al. Platelet deposition in remote cardiac regions after coronary occlusion. Eur J Clin Invest 2007; 37: 939-946.
    • (2007) Eur J Clin Invest , vol.37 , pp. 939-946
    • Barrabés, J.A.1    Mirabet, M.2    Agulló, L.3
  • 31
    • 0021943012 scopus 로고
    • Identification of hydrogen peroxide and hydroxyl radicals as mediators of leukocyte-induced myocardial dysfunction. Limitation of infarct size with neutrophil inhibition and depletion
    • Hess ML, Rowe GT, Caplan M, et al. Identification of hydrogen peroxide and hydroxyl radicals as mediators of leukocyte-induced myocardial dysfunction. Limitation of infarct size with neutrophil inhibition and depletion. Adv Myocardiol 1985; 5: 159-175.
    • (1985) Adv Myocardiol , vol.5 , pp. 159-175
    • Hess, M.L.1    Rowe, G.T.2    Caplan, M.3
  • 32
    • 0032999109 scopus 로고    scopus 로고
    • Effect of sialyl Lewis(x) oligosaccharide on myocardial and cerebral injury in the pig
    • Tofukuji M, Metais C, Collard CD, et al. Effect of sialyl Lewis(x) oligosaccharide on myocardial and cerebral injury in the pig. Ann Thorac Surg 1999; 67: 112-119.
    • (1999) Ann Thorac Surg , vol.67 , pp. 112-119
    • Tofukuji, M.1    Metais, C.2    Collard, C.D.3
  • 33
    • 0026643006 scopus 로고
    • Effect of myocardial ischaemia-reperfusion on granulocyte elastase release
    • Ceriana P. Effect of myocardial ischaemia-reperfusion on granulocyte elastase release. Anaesth Intensive Care 1992; 20: 187-190.
    • (1992) Anaesth Intensive Care , vol.20 , pp. 187-190
    • Ceriana, P.1
  • 34
    • 0030741238 scopus 로고    scopus 로고
    • ANP protects against reoxygenation-induced hypercontracture in adult cardiomyocytes
    • Hempel AM, Friedrich M, Schlüter KD, et al. ANP protects against reoxygenation-induced hypercontracture in adult cardiomyocytes. Am J Physiol 1997; 273: 244-249.
    • (1997) Am J Physiol , vol.273 , pp. 244-249
    • Hempel, A.M.1    Friedrich, M.2    Schlüter, K.D.3
  • 35
    • 0033022686 scopus 로고    scopus 로고
    • L-arginine limits myocardial cell death secondary to hypoxiareoxygenation by a cGMP-dependent mechanism
    • Agulló L, García-Dorado D, Inserte J, et al. L-arginine limits myocardial cell death secondary to hypoxiareoxygenation by a cGMP-dependent mechanism. Am J Physiol 1999; 276: H1574-1580.
    • (1999) Am J Physiol , vol.276
    • Agulló, L.1    García-Dorado, D.2    Inserte, J.3
  • 36
    • 0033959856 scopus 로고    scopus 로고
    • Urodilatin limits acute reperfusion injury in the isolated rat heart
    • Inserte J, Garcia-Dorado D, Agulló L, et al. Urodilatin limits acute reperfusion injury in the isolated rat heart. Cardiovasc Res 2000; 45: 351-359.
    • (2000) Cardiovasc Res , vol.45 , pp. 351-359
    • Inserte, J.1    Garcia-Dorado, D.2    Agulló, L.3
  • 37
    • 4444278104 scopus 로고    scopus 로고
    • Interplay between SERCA and sarcolemmal Ca2+ efflux pathways controls spontaneous release of Ca2+ from the sarcoplasmic reticulum in rat ventricular myocytes
    • O'Neill SC, Miller L, Hinch R, et al. Interplay between SERCA and sarcolemmal Ca2+ efflux pathways controls spontaneous release of Ca2+ from the sarcoplasmic reticulum in rat ventricular myocytes. J Physiol 2004; 559: 121-128.
    • (2004) J Physiol , vol.559 , pp. 121-128
    • O'Neill, S.C.1    Miller, L.2    Hinch, R.3
  • 38
    • 0035968197 scopus 로고    scopus 로고
    • Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta
    • Ammendola A, Geiselhöringer A, Hofmann F, et al. Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta. J Biol Chem 2001; 276: 24153-24159.
    • (2001) J Biol Chem , vol.276 , pp. 24153-24159
    • Ammendola, A.1    Geiselhöringer, A.2    Hofmann, F.3
  • 39
    • 0031746395 scopus 로고    scopus 로고
    • Atrial natriuretic factor reduces cell coupling in the failing heart, an effect mediated by cyclic GMP
    • De Mello WC. Atrial natriuretic factor reduces cell coupling in the failing heart, an effect mediated by cyclic GMP. J Cardiovasc Pharmacol 1998; 32: 75-79.
    • (1998) J Cardiovasc Pharmacol , vol.32 , pp. 75-79
    • De Mello, W.C.1
  • 40
    • 0031757164 scopus 로고    scopus 로고
    • Role of cyclic nucleotide phosphodiesterases in ischaemic preconditioning
    • Lochner A, Genade S, Tromp E, et al. Role of cyclic nucleotide phosphodiesterases in ischaemic preconditioning. Mol Cell Biochem 1998; 1861: 169-175.
    • (1998) Mol Cell Biochem , vol.1861 , pp. 169-175
    • Lochner, A.1    Genade, S.2    Tromp, E.3
  • 41
    • 0037405193 scopus 로고    scopus 로고
    • B-type natriuretic peptide limits infarct size in rat isolated hearts via KATP channel opening
    • D'Souza S P, Yellon DM, Martin C, et al. B-type natriuretic peptide limits infarct size in rat isolated hearts via KATP channel opening. Am J Physiol Heart Circ Physiol 2003; 284: H1592-1600.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284
    • D'Souza, S.P.1    Yellon, D.M.2    Martin, C.3
  • 42
    • 2542514743 scopus 로고    scopus 로고
    • Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition
    • Kim JS, Ohshima S, Pediaditakis P, et al. Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. Hepatology 2004; 39: 1533-1543.
    • (2004) Hepatology , vol.39 , pp. 1533-1543
    • Kim, J.S.1    Ohshima, S.2    Pediaditakis, P.3
  • 43
    • 0029928061 scopus 로고    scopus 로고
    • cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase
    • Moro MA, Russel RJ, Cellek S, et al. cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase. Proc Natl Acad Sci USA 1996; 93: 1480-1485.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1480-1485
    • Moro, M.A.1    Russel, R.J.2    Cellek, S.3
  • 44
    • 0028843227 scopus 로고
    • Activation of endothelial guanylate cyclase inhibits cellular reactivity
    • Heller R, Bussolino F, Ghigo D, et al. Activation of endothelial guanylate cyclase inhibits cellular reactivity. Agents Actions Suppl 1995; 45: 177-181.
    • (1995) Agents Actions Suppl , vol.45 , pp. 177-181
    • Heller, R.1    Bussolino, F.2    Ghigo, D.3
  • 45
    • 0029874399 scopus 로고    scopus 로고
    • Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors
    • Murohara T, Scalia R, Lefer AM. Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors. Circ Res 1996; 78: 780-789.
    • (1996) Circ Res , vol.78 , pp. 780-789
    • Murohara, T.1    Scalia, R.2    Lefer, A.M.3
  • 46
    • 0029865833 scopus 로고    scopus 로고
    • Functional antagonism between cAMP and cGMP on permeability of coronary endothelial monolayers
    • Hempel A, Noll T, Muhs A, et al. Functional antagonism between cAMP and cGMP on permeability of coronary endothelial monolayers. Am J Physiol Heart Circ Physiol 1996; 270: H1264-H1271.
    • (1996) Am J Physiol Heart Circ Physiol , vol.270
    • Hempel, A.1    Noll, T.2    Muhs, A.3
  • 47
    • 0027136513 scopus 로고
    • Nitric oxide-induced microvascular permeability alterations: A regulatory role for cGMP
    • Kubes P. Nitric oxide-induced microvascular permeability alterations: a regulatory role for cGMP. Am J Physiol Heart Circ Physiol 1993; 265: H1909-H1915.
    • (1993) Am J Physiol Heart Circ Physiol , vol.265
    • Kubes, P.1
  • 48
    • 0032786458 scopus 로고    scopus 로고
    • L-arginine inhibits ischemia-reperfusion lung injury in rabbits
    • Yoshida K, Yoshimura K, Haniuda M. L-arginine inhibits ischemia-reperfusion lung injury in rabbits. J Surg Res 1999; 85: 9-16.
    • (1999) J Surg Res , vol.85 , pp. 9-16
    • Yoshida, K.1    Yoshimura, K.2    Haniuda, M.3
  • 49
    • 0033832073 scopus 로고    scopus 로고
    • Guanylyl cyclases and signaling by cyclic GMP
    • Lucas KA, Pitari GM, Kazerounian S, et al. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev 2000; 52: 375-414.
    • (2000) Pharmacol Rev , vol.52 , pp. 375-414
    • Lucas, K.A.1    Pitari, G.M.2    Kazerounian, S.3
  • 50
    • 10444235057 scopus 로고    scopus 로고
    • Soluble guanylyl cyclase: More secrets revealed
    • Pyriochou A, Papapetropoulos A. Soluble guanylyl cyclase: more secrets revealed. Cell Signal 2005; 17: 407-413.
    • (2005) Cell Signal , vol.17 , pp. 407-413
    • Pyriochou, A.1    Papapetropoulos, A.2
  • 51
    • 0142056753 scopus 로고    scopus 로고
    • Structure, regulation, and function of mammalian membrane guanylyl cyclase receptors, with a focus on guanylyl cyclase-A
    • Kuhn M. Structure, regulation, and function of mammalian membrane guanylyl cyclase receptors, with a focus on guanylyl cyclase-A. Circ Res 2003; 93: 700-709.
    • (2003) Circ Res , vol.93 , pp. 700-709
    • Kuhn, M.1
  • 52
    • 33744552632 scopus 로고    scopus 로고
    • Role of NPR-C natriuretic receptor in nitric oxide system activation induced by atrial natriuretic peptide
    • Costa MA, Elesgaray R, Balaszczuk AM, et al. Role of NPR-C natriuretic receptor in nitric oxide system activation induced by atrial natriuretic peptide. Regul Pept 2006; 135: 63-68.
    • (2006) Regul Pept , vol.135 , pp. 63-68
    • Costa, M.A.1    Elesgaray, R.2    Balaszczuk, A.M.3
  • 53
    • 33846392950 scopus 로고    scopus 로고
    • Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
    • Mount P F, Kemp BE, Power DA. Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol 2007; 42: 271-279.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 271-279
    • Mount, P.F.1    Kemp, B.E.2    Power, D.A.3
  • 54
    • 34250827108 scopus 로고    scopus 로고
    • Understanding eNOS for pharmacological modulation of endothelial function: A translational view
    • Braam B, Verhaar MC. Understanding eNOS for pharmacological modulation of endothelial function: a translational view. Curr Pharm Des. 2007; 13: 1727-1740.
    • (2007) Curr Pharm Des , vol.13 , pp. 1727-1740
    • Braam, B.1    Verhaar, M.C.2
  • 55
    • 34250731849 scopus 로고    scopus 로고
    • Life history of eNOS: Partners and pathways
    • Dudzinski DM, Michel T. Life history of eNOS: partners and pathways. Cardiovasc Res 2007; 75: 247-260.
    • (2007) Cardiovasc Res , vol.75 , pp. 247-260
    • Dudzinski, D.M.1    Michel, T.2
  • 56
    • 0029845537 scopus 로고    scopus 로고
    • Distinct inhibitory ATP-regulated modulatory domain (ARMi) in membrane guanylate cyclases
    • Duda T, Goraczniak R, Sharma RK. Distinct inhibitory ATP-regulated modulatory domain (ARMi) in membrane guanylate cyclases. Biochem J 1996; 319: 279-283.
    • (1996) Biochem J , vol.319 , pp. 279-283
    • Duda, T.1    Goraczniak, R.2    Sharma, R.K.3
  • 57
    • 0035830921 scopus 로고    scopus 로고
    • Sub-second kinetics of the nitric oxide receptor, soluble guanylyl cyclase, in intact cerebellar cells
    • Bellamy TC, Garthwaite J. Sub-second kinetics of the nitric oxide receptor, soluble guanylyl cyclase, in intact cerebellar cells. J Biol Chem 2001; 276: 4287-4292.
    • (2001) J Biol Chem , vol.276 , pp. 4287-4292
    • Bellamy, T.C.1    Garthwaite, J.2
  • 58
    • 0021989056 scopus 로고
    • Protein kinase C catalyzes phosphorylation of guanylate cyclase in vitro
    • Zwiller J, Revel MO, Malviya AN. Protein kinase C catalyzes phosphorylation of guanylate cyclase in vitro. J Biol Chem 1985; 260: 1350-1353.
    • (1985) J Biol Chem , vol.260 , pp. 1350-1353
    • Zwiller, J.1    Revel, M.O.2    Malviya, A.N.3
  • 59
    • 0037053379 scopus 로고    scopus 로고
    • Calcium-independent and cAMP-dependent modulation of soluble guanylyl cyclase activity by G protein-coupled receptors in pituitary cells
    • Kostic TS, Tomi M, Andric SA, et al. Calcium-independent and cAMP-dependent modulation of soluble guanylyl cyclase activity by G protein-coupled receptors in pituitary cells. J Biol Chem 2002; 277: 16412-16418.
    • (2002) J Biol Chem , vol.277 , pp. 16412-16418
    • Kostic, T.S.1    Tomi, M.2    Andric, S.A.3
  • 60
    • 4243083085 scopus 로고    scopus 로고
    • Modulation of soluble guanylate cyclase activity by phosphorylation
    • Murthy KS. Modulation of soluble guanylate cyclase activity by phosphorylation. Neurochem Int 2004; 45: 845-851.
    • (2004) Neurochem Int , vol.45 , pp. 845-851
    • Murthy, K.S.1
  • 61
    • 0036222915 scopus 로고    scopus 로고
    • Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide
    • Zabel U, Kleinschnitz C, Oh P, et al. Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide. Nat Cell Biol 2002; 4: 307-311.
    • (2002) Nat Cell Biol , vol.4 , pp. 307-311
    • Zabel, U.1    Kleinschnitz, C.2    Oh, P.3
  • 62
    • 24344471088 scopus 로고    scopus 로고
    • Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes
    • Agulló L, Garcia-Dorado D, Escalona N, et al. Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes. Cardiovasc Res 2005; 68: 65-74.
    • (2005) Cardiovasc Res , vol.68 , pp. 65-74
    • Agulló, L.1    Garcia-Dorado, D.2    Escalona, N.3
  • 63
    • 33646055216 scopus 로고    scopus 로고
    • The role of oxidants and free radicals in reperfusion injury
    • Zweier JL, Talukder MA. The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res 2006; 70: 181-190.
    • (2006) Cardiovasc Res , vol.70 , pp. 181-190
    • Zweier, J.L.1    Talukder, M.A.2
  • 64
    • 0030872552 scopus 로고    scopus 로고
    • L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischaemia/reperfusion injury in skeletal muscle
    • Huk I, Nanobashvili J, Neumayer C, et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischaemia/reperfusion injury in skeletal muscle. Circulation 1997; 96: 667-675.
    • (1997) Circulation , vol.96 , pp. 667-675
    • Huk, I.1    Nanobashvili, J.2    Neumayer, C.3
  • 65
    • 0028339112 scopus 로고
    • Cyclic GMP in the perfused heart. Effect of ischaemia, anoxia and nitric oxide synthase inhibitor
    • Depré C, Hue L. Cyclic GMP in the perfused heart. Effect of ischaemia, anoxia and nitric oxide synthase inhibitor. FEBS Lett 1994; 345: 241-245.
    • (1994) FEBS Lett , vol.345 , pp. 241-245
    • Depré, C.1    Hue, L.2
  • 66
    • 0028852039 scopus 로고
    • Nitric oxide signaling in ischaemic heart
    • Maulik N, Engelman DT, Watanabe M, et al. Nitric oxide signaling in ischaemic heart. Cardiovasc Res 1995; 30: 593-601.
    • (1995) Cardiovasc Res , vol.30 , pp. 593-601
    • Maulik, N.1    Engelman, D.T.2    Watanabe, M.3
  • 67
    • 0017360317 scopus 로고
    • Cyclic nucleotide levels in the perfused rat heart subjected to hypoxia
    • Nesher R, Robinson WF, Gibb L, et al. Cyclic nucleotide levels in the perfused rat heart subjected to hypoxia. Experientia 1977; 33: 215-217.
    • (1977) Experientia , vol.33 , pp. 215-217
    • Nesher, R.1    Robinson, W.F.2    Gibb, L.3
  • 68
    • 0030752565 scopus 로고    scopus 로고
    • Activation of cardiac muscarinic receptor and ischaemic preconditioning effects in in situ rat heart
    • Yamaguchi F, Nasa Y, Yabe K, et al. Activation of cardiac muscarinic receptor and ischaemic preconditioning effects in in situ rat heart. Heart Vessels 1997; 12: 74-83.
    • (1997) Heart Vessels , vol.12 , pp. 74-83
    • Yamaguchi, F.1    Nasa, Y.2    Yabe, K.3
  • 69
    • 0032942266 scopus 로고    scopus 로고
    • Amelioration by quinapril of myocardial infarction induced by coronary occlusion/reperfusion in a rabbit model of atherosclerosis. Possible mechanisms
    • Hoshida S, Yamashita N, Kawahara K, et al. Amelioration by quinapril of myocardial infarction induced by coronary occlusion/reperfusion in a rabbit model of atherosclerosis. Possible mechanisms. Circulation 1999; 99: 434-440.
    • (1999) Circulation , vol.99 , pp. 434-440
    • Hoshida, S.1    Yamashita, N.2    Kawahara, K.3
  • 70
    • 0035882197 scopus 로고    scopus 로고
    • Intravenous administration of the natriuretic peptide urodilatin at low doses during coronary reperfusion limits infarct size in anesthetized pigs
    • Padilla F, Garcia-Dorado D, Agulló L, et al. Intravenous administration of the natriuretic peptide urodilatin at low doses during coronary reperfusion limits infarct size in anesthetized pigs. Cardiovasc Res 2001; 51: 592-600.
    • (2001) Cardiovasc Res , vol.51 , pp. 592-600
    • Padilla, F.1    Garcia-Dorado, D.2    Agulló, L.3
  • 71
    • 0038104906 scopus 로고    scopus 로고
    • Effect of ischaemia on soluble and particulate guanylyl cyclasemediated cGMP synthesis in cardiomyocytes
    • Agulló L, Garcia-Dorado D, Escalona N, et al. Effect of ischaemia on soluble and particulate guanylyl cyclasemediated cGMP synthesis in cardiomyocytes. Am J Physiol Heart Circ Physiol 2003; 284: 2170-2176.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284 , pp. 2170-2176
    • Agulló, L.1    Garcia-Dorado, D.2    Escalona, N.3
  • 72
    • 0030250079 scopus 로고    scopus 로고
    • Effect of anoxia on cyclic nucleotides and inositol phosphate turnover in cardiac myocytes
    • Geisbuhler T P, Schwager TL. Effect of anoxia on cyclic nucleotides and inositol phosphate turnover in cardiac myocytes. J Mol Cell Cardiol 1996; 28: 1857-1866.
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 1857-1866
    • Geisbuhler, T.P.1    Schwager, T.L.2
  • 73
    • 0036350531 scopus 로고    scopus 로고
    • Hypoxia and acidosis impair cGMP synthesis in microvascular coronary endothelial cells
    • Agulló L, Garcia-Dorado D, Escalona N, et al. Hypoxia and acidosis impair cGMP synthesis in microvascular coronary endothelial cells. Am J Physiol Heart Circ Physiol 2002; 283: H917-925.
    • (2002) Am J Physiol Heart Circ Physiol , vol.283
    • Agulló, L.1    Garcia-Dorado, D.2    Escalona, N.3
  • 74
    • 0030741238 scopus 로고    scopus 로고
    • ANP protects against reoxygenation-induced hypercontracture in adult cardiomyocytes
    • Hempel AM, Friedrich M, Schlüter KD, et al. ANP protects against reoxygenation-induced hypercontracture in adult cardiomyocytes. Am J Physiol 1997; 273: 244-249.
    • (1997) Am J Physiol , vol.273 , pp. 244-249
    • Hempel, A.M.1    Friedrich, M.2    Schlüter, K.D.3
  • 75
    • 0034110883 scopus 로고    scopus 로고
    • L-Arginine administration prevents reperfusion-induced cardiomyocyte hypercontracture and reduces infarct size in the pig
    • Padilla F, Garcia-Dorado D, Agulló L, et al. L-Arginine administration prevents reperfusion-induced cardiomyocyte hypercontracture and reduces infarct size in the pig. Cardiovasc Res 2000; 46: 412-420.
    • (2000) Cardiovasc Res , vol.46 , pp. 412-420
    • Padilla, F.1    Garcia-Dorado, D.2    Agulló, L.3
  • 76
    • 33745225625 scopus 로고    scopus 로고
    • Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts
    • Yang XM, Philipp S, Downey JM, et al. Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts. Basic Res Cardiol. 2006; 101: 311-318.
    • (2006) Basic Res Cardiol , vol.101 , pp. 311-318
    • Yang, X.M.1    Philipp, S.2    Downey, J.M.3
  • 77
    • 20844433399 scopus 로고    scopus 로고
    • Experimental study on myocardial protection by adjunct use of carperitide (hANP) in cardiac surgery
    • Wakui S. Experimental study on myocardial protection by adjunct use of carperitide (hANP) in cardiac surgery. Ann Thorac Cardiovasc Surg 2005; 11: 12-20.
    • (2005) Ann Thorac Cardiovasc Surg , vol.11 , pp. 12-20
    • Wakui, S.1
  • 78
    • 20044369754 scopus 로고    scopus 로고
    • Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model
    • du Toit E F, Rossouw E, Salie R, et al. Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model. Cardiovasc Drugs Ther 2005; 19: 23-31.
    • (2005) Cardiovasc Drugs Ther , vol.19 , pp. 23-31
    • du Toit, E.F.1    Rossouw, E.2    Salie, R.3
  • 79
    • 42949087451 scopus 로고    scopus 로고
    • Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG
    • Maas O, Donat U, Frenzel M, et al. Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG. Br J Pharmacol 2008; 154: 25-31.
    • (2008) Br J Pharmacol , vol.154 , pp. 25-31
    • Maas, O.1    Donat, U.2    Frenzel, M.3
  • 80
    • 0035369120 scopus 로고    scopus 로고
    • Intravenous atrial natriuretic peptide prevents left ventricular remodeling in patients with first anterior acute myocardial infarction
    • Hayashi M, Tsutamoto T, Wada A, et al. Intravenous atrial natriuretic peptide prevents left ventricular remodeling in patients with first anterior acute myocardial infarction. J Am Coll Cardiol. 2001; 37: 1820-1826.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1820-1826
    • Hayashi, M.1    Tsutamoto, T.2    Wada, A.3
  • 81
    • 35448998412 scopus 로고    scopus 로고
    • J-WIND investigators. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): Two randomised trials
    • Kitakaze M, Asakura M, Kim J, et al.; J-WIND investigators. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials. Lancet 2007; 370: 1483-1493.
    • (2007) Lancet , vol.370 , pp. 1483-1493
    • Kitakaze, M.1    Asakura, M.2    Kim, J.3
  • 82
    • 41149084540 scopus 로고    scopus 로고
    • Mapping preconditioning's signaling pathways: An engineering approach
    • Downey JM, Krieg T, Cohen M V. Mapping preconditioning's signaling pathways: an engineering approach. Ann NY Acad Sci 2008; 1123: 187-196.
    • (2008) Ann NY Acad Sci , vol.1123 , pp. 187-196
    • Downey, J.M.1    Krieg, T.2    Cohen, M.V.3
  • 83
    • 0036889534 scopus 로고    scopus 로고
    • ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases
    • Krieg T, Qin Q, McIntosh EC, et al. ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases. Am J Physiol Heart Circ Physiol 2002; 283: H2322-2330.
    • (2002) Am J Physiol Heart Circ Physiol , vol.283
    • Krieg, T.1    Qin, Q.2    McIntosh, E.C.3
  • 84
    • 0347628950 scopus 로고    scopus 로고
    • Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection
    • Heart Circ Physiol
    • Oldenburg O, Qin Q, Krieg T, et al. Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection. Am J Physiol Heart Circ Physiol 2004; 286: H468-476.
    • (2004) Am J Physiol , vol.286
    • Oldenburg, O.1    Qin, Q.2    Krieg, T.3
  • 85
    • 3242703181 scopus 로고    scopus 로고
    • Exogenous NO triggers preconditioning via a cGMP- and mitoKATP- dependent mechanism
    • Qin Q, Yang XM, Cui L, et al. Exogenous NO triggers preconditioning via a cGMP- and mitoKATP- dependent mechanism. Am J Physiol Heart Circ Physiol 2004; 287: H712-718.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Qin, Q.1    Yang, X.M.2    Cui, L.3
  • 86
    • 24044492874 scopus 로고    scopus 로고
    • Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria
    • Costa AD, Garlid KD, West IC, et al. Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res 2005; 97: 329-336.
    • (2005) Circ Res , vol.97 , pp. 329-336
    • Costa, A.D.1    Garlid, K.D.2    West, I.C.3
  • 87
    • 12344311866 scopus 로고    scopus 로고
    • Ischaemic preconditioning protects by activating prosurvival kinases at reperfusion
    • Hausenloy DJ, Tsang A, Mocanu MM, et al. Ischaemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol 2005; 288: H971-976.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Hausenloy, D.J.1    Tsang, A.2    Mocanu, M.M.3
  • 88
    • 85047692700 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
    • Juhaszova M, Zorov DB, Kim SH, et al. Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest 2004; 113: 1535-1549.
    • (2004) J Clin Invest , vol.113 , pp. 1535-1549
    • Juhaszova, M.1    Zorov, D.B.2    Kim, S.H.3
  • 89
    • 33746207800 scopus 로고    scopus 로고
    • Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection
    • Rodriguez-Sinovas A, Boengler K, Cabestrero A, et al. Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. Circ Res 2006; 99: 93-101.
    • (2006) Circ Res , vol.99 , pp. 93-101
    • Rodriguez-Sinovas, A.1    Boengler, K.2    Cabestrero, A.3
  • 90
    • 38849201088 scopus 로고    scopus 로고
    • Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury
    • Ruiz-Meana M, Rodríguez-Sinovas A, Cabestrero A, et al. Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury. Cardiovasc Res 2008; 77: 325-333.
    • (2008) Cardiovasc Res , vol.77 , pp. 325-333
    • Ruiz-Meana, M.1    Rodríguez-Sinovas, A.2    Cabestrero, A.3
  • 91
    • 25444512382 scopus 로고    scopus 로고
    • Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice
    • Heinzel FR, Luo Y, Li X, et al. Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice. Circ Res 2005; 97: 583-586.
    • (2005) Circ Res , vol.97 , pp. 583-586
    • Heinzel, F.R.1    Luo, Y.2    Li, X.3
  • 92
    • 33745242990 scopus 로고    scopus 로고
    • No loss of cardioprotection by postconditioning in connexin 43-deficient mice
    • Heusch G, Büchert A, Feldhaus S, et al. No loss of cardioprotection by postconditioning in connexin 43-deficient mice. Basic Res Cardiol 2006; 101: 354-356.
    • (2006) Basic Res Cardiol , vol.101 , pp. 354-356
    • Heusch, G.1    Büchert, A.2    Feldhaus, S.3
  • 93
    • 4444309577 scopus 로고    scopus 로고
    • Glycine protects cardiomyocytes against lethal reoxygenation injury by inhibiting mitochondrial permeability transition
    • Ruiz-Meana M, Pina P, Garcia-Dorado D, et al. Glycine protects cardiomyocytes against lethal reoxygenation injury by inhibiting mitochondrial permeability transition. J Physiol 2004; 558: 873-882.
    • (2004) J Physiol , vol.558 , pp. 873-882
    • Ruiz-Meana, M.1    Pina, P.2    Garcia-Dorado, D.3
  • 94
    • 57749191674 scopus 로고    scopus 로고
    • Delayed recovery of intracellular acidosis during reperfusion prevents calpain activation and determines protection in postconditioned myocardium
    • Inserte J, Barba I, Hernando V, et al. Delayed recovery of intracellular acidosis during reperfusion prevents calpain activation and determines protection in postconditioned myocardium. Cardiovasc Res 2009; 81: 116-122.
    • (2009) Cardiovasc Res , vol.81 , pp. 116-122
    • Inserte, J.1    Barba, I.2    Hernando, V.3


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