L-arginine limits myocardial cell death secondary to hypoxia- reoxygenation by a cGMP-dependent mechanism

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 276, Issue 5 45-5, 1999, Pages

  Agulló, Luis ^a   García Dorado, David ^a   Inserte, Javier ^a   Paniagua, Amaya ^a   Pyrhonen, Pasi ^a   Llevadot, Joan ^a   Soler Soler, Jordi ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Contractile function; Guanylyl cyclase inhibition; Isolated rat heart; Myocytes; Nitric oxide; Reperfusion; Uptake

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ARGININE; CYCLIC GMP; LACTATE DEHYDROGENASE;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL HYPOXIA; CORONARY ARTERY BLOOD FLOW; ENZYME RELEASE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CELL; HEART PROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION;

EID: 0033022686     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.276.5.h1574     Document Type: Article

References (40)

1. Agulló, L., and A. García. Characterization of noradrenaline-stimulated cyclic GMP formation in brain astrocytes in culture. Biochem. J. 288: 619-624, 1992.
2. Amrani, M., C. C. Gray, R. T. Smolenski, A. T. Goodwin, A. London, and M. H. Yacoub. The effect of L-arginine on myocardial recovery after cardioplegic arrest and ischemia under moderate and deep hypothermia. Circulation 96, Suppl. II: 274-279, 1997.
3. Brunner, F. Interaction of nitric oxide and endothelin-1 in ischemia/reperfusion injury of rat heart. J. Mol. Cell Cardiol. 29: 2363-2374, 1997.
4. Busse, R., and I. Fleming. Regulation and functional consequences of endothelial nitric oxide formation. Ann. Med. 27: 331-340, 1995.
5. Cope, J. T., D. Banks, and O. A. Binns. Sodium nitroprusside exacerbates myocardial ischemia-reperfusion injury. Ann. Thorac. Surg. 64: 1656-1659, 1997.
6. Depré, C., L. Fiérain, and L. Hue. Activation of nitric oxide synthase by ischemia in the perfused heart. Cardiovasc. Res. 33: 82-87, 1997.
7. Depré, C., J. L. Vanoverschelde, J. F. Goudemant, I. Mottet, and L. Hue. Protection against ischemic injury by nonvasoactive concentrations of nitric oxide synthase inhibitors in the perfused rabbit heart. Circulation 92: 1911-1918, 1995.
8. Draper, N. J., and A. M. Shah. Beneficial effects of a nitric oxide donor on recovery of contractile function following brief hypoxia in isolated rat heart. J. Mol. Cell Cardiol. 29: 1195-1205, 1997.
9. Engelman, D. T., M. Watanabe, R. M. Engelman, J. A. Rousou, J. E. Flack III, D. W. Deaton, and D. K. Das. Constitutive nitric oxide release is impaired after ischemia and reperfusion. J. Thorac. Cardiovasc. Surg. 110: 1047-1053, 1995.
10. García-Dorado, D., P. Théroux, J. M. Duran, J. S. Solares, J. Alonso, E. Sanz, R. Munoz, J. Elizaga, J. Botas, F. Fernandez-Avilés, J. Soriano, and E. Esteban. Selective inhibition of the contractile apparatus. Circulation 85: 1160-1174, 1992.
11. Garlick, P. B., M. J. Davies, D. J. Hearse, and T. F. Slater. Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy. Circ. Res. 61: 757-760, 1987.
12. Garthwaite, J., E. Southam, C. L. Boulton, E. B. Nielsen, K. Schmidt, and B. Mayer. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3,-α]quinoxalin-1-one. Mol. Pharmacol. 48: 184-188, 1995.
13. Griffith, O. W., and D. J. Stuehr. Nitric oxide synthases: properties and catalytic mechanism. Annu. Rev. Physiol. 57: 707-736, 1995.
14. Gross, S. S., and M. S. Wolin. Nitric oxide: pathophysiological mechanisms. Annu. Rev. Physiol. 57: 737-769, 1995.
15. Hempel, A., M. Friedrich, K. D. Schlüter, W. G. Forssmann, M. Kuhn, and H. M. Piper. ANP protects against reoxygenation-induced hypercontracture in adult cardiomyocytes. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H244-H249, 1997.
16. Huk, I., J. Nanobashvili, C. Neumayer, A. Punz, M. Mueller, K. Afkhampour, M. Mittlboeck, U. Losert, P. Polterauer, E. Roth, S. Patton, and T. Malinski. L-Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation 96: 667-675, 1997.
17. + exchange occurring during hypoxia in the genesis of reoxygenation-induced myocardial oedema. J. Mol. Cell Cardiol. 29: 1167-1175, 1997.
18. Kelm, M., S. Schäfer, R. Dahmann, B. Dolu, S. Perings, U. K. M. Decking, J. Schrader, and B. E. Strauer. Nitric oxide induced contractile dysfunction is related to a reduction in myocardial energy generation. Cardiovasc. Res. 36: 185-194, 1987.
19. Knowles, R. G., M. Palacios, R. M. J. Palmer, and S. Moncada. Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc. Natl. Acad. Sci. USA 86: 5159-5162, 1989.
20. Maulik, N., D. T. Engelman, M. Watanabe, R. M. Engelman, J. A. Rousou, J. E. Flack III, D. W. Deaton, N. V. Gorbunov, N. M. Elsayed, V. E. Kagan, and D. K. Das. Nitric oxide/carbon monoxide. A molecular switch for myocardial preservation during ischemia. Circulation 94, Suppl. II: II-398-II-406, 1996.
21. Moro, M. A., R. J. Russell, S. Cellek, I. Lizasoain, Y. Su, V. M. Darley-Usmar, M. W. Radomski, and S. Moncada. cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase. Proc. Natl. Acad. Sci. USA 93: 1480-1485, 1996.
22. Nagase, S., K. Takemura, A. Ueda, A. Hirayama, K. Aoyagi, M. Kondoh, and A. Koyama. A novel nonenzymatic pathway for the generation of nitric oxide by the reaction of hydrogen peroxide and D-or L-arginine. Biochem. Biophys. Res. Commun 233: 150-153, 1997.
23. G-nitro-L-arginine improves myocardial function following ischemia/reperfusion in isolated perfused rat heart. J. Mol. Cell Cardiol. 27: 419-426, 1995.
24. Pabla, R., and M. J. Curtis. Effect of endogenous nitric oxide on cardiac systolic and diastolic function during ischemia and reperfusion in the rat isolated perfused heart. J. Mol. Cell Cardiol. 28: 2111-2121, 1996.
25. Pfitzer, G., J. C. Rüegg, V. Flockerzi, and F. Hofmann. cGMP-dependent protein kinase decreases calcium sensitivity of skinned cardiac fibers. FEBS Lett. 149: 171-175, 1982.
26. Pryor, W. A., and G. L. Squadrito. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am. J. Physiol. 268 (Lung Cell. Mol. Physiol. 12): L699-L722, 1995.
27. Ruiz-Meana, M., D. García-Dorado, M. A. González, J. A. Barrabés, and J. Soler-Soler. Effect of osmotic stress on sarcolemmal integrity of isolated cardiomyocytes following transient metabolic inhibition. Cardiovasc. Res. 30: 64-69, 1995.
28. Shah, A. M., M. J. Lewis, and A. H. Henderson. Effects of 8-bromo-cyclic GMP on contraction and on ionotropic response of ferret cardiac muscle. J. Mol. Cell Cardiol. 23: 55-64, 1991.
29. 2+ in intact cardiac myocytes. Circ. Res. 74: 970-978, 1994.
30. Siegfried, M. R., J. Erhardt, T. Rider, X. Ma, and A. M. Lefer. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J. Pharmacol. Exp. Ther. 260: 668-675, 1992.
31. Siegmund, B., T. Klietz, P. Schwartz, and H. M. Piper. Temporary contractile blockade prevents hypercontracture in anoxic-reoxygenated cardiomyocytes. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H426-H435, 1991.
32. Siegmund, B. A., A. Koop, T. Klietz, P. Schwartz, and H. M. Piper. Sarcolemmal integrity and metabolic competence of cardiac myocytes under anoxia-reoxygenation. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H285-H291, 1990.
33. Tsao, P. S., N. Aoki, D. J. Lefer, G. Johnson, and A. M. Lefer. Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation 82: 1402-1412, 1990.
34. Wahler, G. M., N. J. Rusch, and N. Sperelakis. 8-Bromo-cyclic GMP inhibits the calcium channel current in embryonic chick ventricular myocytes. Can. J. Physiol. Pharmacol. 68: 531-534, 1989.
35. Wang, P., and J. L. Zweier. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. J. Biol. Chem. 271: 29223-29230, 1996.
36. Weyrich, A. S., X. Ma, and A. M. Lefer. The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation 86: 279-288, 1992.
37. Woolfson, R. G., V. C. Patel, G. H. Neild, and D. M. Yellon. Inhibition of nitric oxide synthesis reduces infarct size by an adenosine-dependent mechanism. Circulation 91: 1545-1551, 1995.
38. Yasmin, W., K. D. Strynadka, and R. Schulz. Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovasc. Res. 33: 422-432, 1997.
39. Zharikov, S. I., H. Herrera, and E. R. Block. Role of membrane potential in hypoxic inhibition of L-arginine uptake by lung endothelial cells. Am. J. Physiol. 272 (Lung Cell. Mol. Physiol. 16): L78-L84, 1997.
40. Zweier, J. L., P. Wang, and P. Kuppusamy. Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J. Biol. Chem. 270: 304-307, 1995.