Substrate flexibility of the adenylation reaction in the Tyrocidine non-ribosomal peptide synthetase

Journal of Molecular Catalysis B: Enzymatic

Volumn 59, Issue 1-3, 2009, Pages 140-144

  Schaffer, Michelle L ^a   Otten, Linda G ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Adenylation; ATP PPi exchange assay; Combinatorial biosynthesis; Enzymatic promiscuity; Non ribosomal peptide synthetase (NRPS); Substrate specificity

Indexed keywords

ADENYLATION; ATP-PPI EXCHANGE ASSAY; COMBINATORIAL BIOSYNTHESIS; ENZYMATIC PROMISCUITY; NON-RIBOSOMAL PEPTIDE SYNTHETASE (NRPS); SUBSTRATE SPECIFICITY;

AMINES; AMINO ACIDS; ANTIBIOTICS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CHEMICAL ACTIVATION; ORGANIC ACIDS; PUMPING PLANTS;

SUBSTRATES;

ADENOSINE TRIPHOSPHATE; NATURAL PRODUCT; PEPTIDYL CARRIER PROTEIN; PHENYLALANINE; TYROCIDINE;

ADENYLATION; ARTICLE; BIOSYNTHESIS; CATALYSIS; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; NONRIBOSOMAL PEPTIDE SYNTHESIS; PROTEIN DOMAIN;

EID: 64649092262     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcatb.2009.02.004     Document Type: Article

References (33)

1. von Dohren H., Keller U., Vater J., and Zocher R. Chem. Rev. 97 (1997) 2675-2706
2. Mootz H.D., Schwarzer D., and Marahiel M.A. ChemBioChem 3 (2002) 490-504
3. Sieber S.A., and Marahiel M.A. Chem. Rev. 105 (2005) 715-738
4. Weissman K.J., and Muller R. ChemBioChem 9 (2008) 826-848
5. Walsh C.T. Science 303 (2004) 1805-1810
6. Vosburg D.A., and Walsh C.T. Ernst Schering Res. Found. Workshop (2005) 261-284
7. Stachelhaus T., Huser A., and Marahiel M.A. Chem. Biol. 3 (1996) 913-921
8. Stachelhaus T., Mootz H.D., Bergendahl V., and Marahiel M.A. J. Biol. Chem. 273 (1998) 22773-22781
9. Stachelhaus T., Mootz H.D., and Marahiel M.A. Chem. Biol. 6 (1999) 493-505
10. von Dohren H., Dieckmann R., and Pavela-Vrancic M. Chem. Biol. 6 (1999) R273-R279
11. Challis G.L., Ravel J., and Townsend C.A. Chem. Biol. 7 (2000) 211-224
12. Mootz H.D., Schwarzer D., and Marahiel M.A. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 5848-5853
13. Fischbach M.A., Lai J.R., Roche E.D., Walsh C.T., and Liu D.R. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 11951-11956
14. Butz D., Schmiederer T., Hadatsch B., Wohlleben W., Weber T., and Sussmuth R.D. ChemBioChem 9 (2008) 1195-1200
15. Baltz R.H. Curr. Top. Med. Chem. 8 (2008) 618-638
16. Eppelmann K., Stachelhaus T., and Marahiel M.A. Biochemistry 41 (2002) 9718-9726
17. Lee S.G., and Lipmann F. Methods Enzymol. 43 (1975) 585-602
18. Marahiel M.A., Krause M., and Skarpeid H.J. Mol. Gen. Genet. 201 (1985) 231-236
19. Mootz H.D., and Marahiel M.A. J. Bacteriol. 179 (1997) 6843-6850
20. Ruttenberg M.A., and Mach B. Biochemistry 5 (1966) 2864-2869
21. Fujikawa K., Sakamoto Y., Suzuki T.J., and Kurahashi K. Biochim. Biophys. Acta (BBA)-Nucleic Acids Protein Synth. 169 (1968) 520-533
22. Conti E., Stachelhaus T., Marahiel M.A., and Brick P. EMBO J. 16 (1997) 4174-4183
23. Tanovic A., Samel S.A., Essen L.O., and Marahiel M.A. Science 321 (2008) 659-663
24. May J.J., Kessler N., Marahiel M.A., and Stubbs M.T. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 12120-12125
25. Luo L., and Walsh C.T. Biochemistry 40 (2001) 5329-5337
26. Luo L., Burkart M.D., Stachelhaus T., and Walsh C.T. J. Am. Chem. Soc. 123 (2001) 11208-11218
27. Gruenewald S. In vitro- und in vivo-Untersuchungen zur Evolution nichtribosomaler Peptidsynthetasen, Ph.D. Thesis (2005), Philipps-Universität Marburg, Marburg DE
28. Pfeifer E., Pavela-Vrancic M., von Dohren H., and Kleinkauf H. Biochemistry 34 (1995) 7450-7459
29. Otten L.G., Schaffer M.L., Villiers B.R.M., Stachelhaus T., and Hollfelder F. Biotechnol. J. 2 (2007) 232-240
30. Skarpeid H.J., Zimmer T.L., Shen B., and von Dohren H. Eur. J. Biochem. 187 (1990) 627-633
31. Dieckmann R., Lee Y.O., van Liempt H., von Dohren H., and Kleinkauf H. FEBS Lett. 357 (1995) 212-216
32. Vater J., and Kleinkauf H. Biochim. Biophys. Acta 429 (1976) 1062-1072
33. Wallace A.C., Laskowski R.A., and Thornton J.M. Protein Eng. 8 (1995) 127-134