Genome-wide cDNA microarray screening to correlate gene expression profiles with sensitivity of 85 human cancer xenografts to anticancer drugs

Cancer Research

Volumn 62, Issue 2, 2002, Pages 518-527

  Zembutsu, Hitoshi ^a,e   Furukawa, Yoichi ^a   Katagiri, Toyomasa ^a   Kitahara, Osamu ^a   Yanagawa, Rempei ^a   Nakamura, Yusuke ^a   Ohnishi, Yasuyuki ^b   Tamaoki, Norikazu ^b   Nomura, Tatsuji ^b   Tsunoda, Tatsuhiko ^c   Ueyama, Yoshito ^d   Hirata, Koichi ^e  

^a UNIVERSITY OF TOKYO   (Japan)

^b CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^c INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^d TOKAI UNIVERSITY   (Japan)

^e SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; COMPLEMENTARY DNA; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; METHOTREXATE; MITOMYCIN C; NIMUSTINE; VINBLASTINE; VINCRISTINE;

ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER TRANSPLANTATION; CHEMOSENSITIVITY; DIGESTIVE SYSTEM CANCER; GENE EXPRESSION; GENOME; GLIOMA; GYNECOLOGIC CANCER; HUMAN; HUMAN TISSUE; LUNG CANCER; MAJOR CLINICAL STUDY; MOUSE; NEUROBLASTOMA; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0037081081     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Clinical applications of the histoculture drug response assay
2. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
3. The human multidrug resistance (mdr1) gene. Cdna cloning and transcription initiation
4. Gene expression and amplification in breast carcinoma cells with intrinsic and acquired doxorubicin resistance
5. Systematic variation in gene expression patterns in human cancer cell lines
6. A gene expression database for the molecular pharmacology of cancer
7. Responsiveness of human gastric tumors implanted in nude mice to clinically equivalent doses of various antitumor agents
8. Anticancer drug sensitivities of human tumors transplanted in nude mice
9. Identification by cDNA microarray of genes involved in ovarian carcinogenesis
10. Prediction of sensitivity of esophageal tumors to adjuvant chemotherapy by cDNA microarray analysis of gene-expression profiles
11. Responsiveness of subcutaneous human glioma xenografts to various antitumor agents
12. Evaluation of antitumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose
13. Responsiveness of human lung cancer/nude mouse to antitumor agents in a model using clinically equivalent doses
14. Considerations in the use of nude mice for cancer research
15. Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis
16. Ultrastructural and morphometric features of poorly differentiated and undifferentiated lung tumors
17. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
18. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
19. Decreased DNA topoisomerase II α expression and cold-sensitive growth in a mouse mammary cancer cell line resistant to etoposide and doxorubicin
20. Doxorubicin-induced DNA breaks, topoisomerase II activity and gene expression in human melanoma cells
21. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
22. Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells
23. Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells
24. r 193, 000 vault protein is up-regulated in multidrug-resistant cancer cell lines
25. Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffinembedded tissues
26. Expression of cytochromes P450 in human breast tissue and tumors
27. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
28. Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans
29. Pharmacogenetics of anticancer agents: Lessons from amonafide and irinotecan
30. Identification and characterization of genes associated with human hepatocellular carcinogenesis
31. Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression
32. A family of drug transporters: The multidrug resistance-associated proteins
33. 1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-hydroxystaurosporine)
34. The mouse mitotic checkpoint gene bubIb, a novel bubI family member, is expressed in a cell cycle-dependent manner
35. 2 phase arrest by different antitumor agents
36. 2-arrest in Chinese hamster ovary cells treated with anticancer drugs
37. Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human a class glutathione S-transferase gene
38. Inhibition of cyclin DI expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes
39. Sensitivity of cyclin E-overexpressing cells to cisplatin/Taxol combinations