Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains

Immunome Research

Volumn 5, Issue 1, 2009, Pages

  Volpe, Joseph M ^a,c   Kepler, Thomas B ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; B LYMPHOCYTE; GENE FREQUENCY; GENE MUTATION; GENE REARRANGEMENT; GENETIC CORRELATION; IMMUNOGLOBULIN GENE; IMMUNOREACTIVITY; PRE B LYMPHOCYTE; SOMATIC MUTATION;

EID: 64649086139     PISSN: None     EISSN: 17457580     Source Type: Journal    
DOI: 10.1186/1745-7580-5-1     Document Type: Article

References (34)

1. Somatic generation of antibody diversity. S Tonegawa, Nature 1983 302 5909 575 581 10.1038/302575a0 6300689
2. Organization of human immunoglobulin heavy chain diversity gene loci. Y Ichiara H Matsuoka Y Kurosawa, EMBO J 1988 7 13 4141 4150 3243276
3. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. I Sanz, J Immunol 1991 147 5 1720 1729 1908883
4. Generation of antibody diversity in the immune response of BALBc mice to influenza virus hemagglutinin. D McKean K Hüppi M Bell L Staudt W Gerhard M Weigert, Proc Natl Acad Sci 1984 81 10 3180 3184 6203114 10.1073/pnas.81.10. 3180
5. Predominant autoantibody production by early human B cell precursors. H Wardemann S Yurasov A Schaefer JW Young E Meffre MC Nussenzweig, Science 2003 301 5638 1374 1377 10.1126/science.1086907 12920303
6. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. C Goodnow J Crosbie S Adelstein TB Lavoie SJ Smith-Gill RA Brink H Pritchard-Briscoe JS Wotherspoon RH Loblay K Raphael RJ Trent A Basten, Nature 1988 334 6184 676 682 10.1038/334676a0 3261841
7. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. DA Nemazee K Bürki, Nature 1989 337 6207 562 566 10.1038/337562a0 2783762
8. Receptor editing in self-reactive bone marrow B cells. SL Tiegs DM Russell D Nemazee, J Exp Med 1993 177 4 1009 1020 8459201 10.1084/jem.177.4.1009
9. Receptor editing: an approach by autoreactive B cells to escape tolerance. D Gay T Saunders S Camper M Weigert, J Exp Med 1993 177 4 999 1008 8459227 10.1084/jem.177.4.999
10. Cellular and genetic mechanisms of self tolerance and autoimmunity. C Goodnow J Sprent B Fazekas de St Groth CG Vinuesa, Nature 2005 435 7042 590 597 10.1038/nature03724 15931211
11. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. Y Ichiyoshi P Casali, J Exp Med 1994 180 3 885 895 8064239 10.1084/jem.180.3.885
12. Structure-function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain. T Martin R Crouzier JC Weber TJ Kipps JL Pasquali, J Immunol 1994 152 12 5988 5996 8207223
13. IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth. S Shiokawa F Mortari JO Lima C Nũez FE Bertrand 3rd PM Kirkham S Zhu AP Dasanayake HW Schroeder Jr, J Immunol 1999 162 10 6060 6070 10229847
14. Molecular structure of eight human autoreactive monoclonal antibodies. I Aguilera J Melero A Nũez Roldan B Sanchez, Immunology 2001 102 3 273 280 11298825 10.1046/j.1365-2567.2001.01159.x
15. Self-reactive antibodies (natural autoantibodies) in healthy individuals. S Lacroix-Desmazes SV Kaveri L Mouthon A Ayouba E Malanchère A Coutinho MD Kazatchkine, J Immunol Methods 1998 216 1-2 117 137 10.1016/S0022-1759(98) 00074-X 9760219
16. Positive selection of natural autoreactive B cells. K Hayakawa M Asano SA Shinton M Gui D Allman CL Stewart J Silver RR Hardy, Science 1999 285 5424 113 116 10.1126/science.285.5424.113 10390361
17. The role of clonal selection and somatic mutation in autoimmunity. MJ Shlomchik A Marshak-Rothstein CB Wolfowicz TL Rothstein M Weigert, Nature 1987 328 6133 805 811 10.1038/328805a0 3498121
18. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. M Shlomchik M Mascelli H Shan MZ Radic D Disetsky A Marshak-Rothstein M Weigert, J Exp Med 1990 171 265 292 2104919 10.1084/jem.171.1.265
19. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. TH Winkler H Fehr JR Kalden, Eur J Immunol 1992 22 7 1719 1728 10.1002/eji.1830220709 1623920
20. The role of somatic mutation in the pathogenic anti-DNA response. B Diamond JB Katz E Paul C Aranow D Lustgarten MD Scharff, Annu Rev Immunol 1992 10 731 757 1591002 10.1146/annurev.iy.10.040192.003503
21. Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen. LP Casson T Manser, J Exp Med 1995 182 3 743 750 7650481 10.1084/jem.182.3.743
22. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. SK Ray C Putterman B Diamond, Proc Natl Acad Sci 1996 93 2019 2024 8700878 10.1073/pnas.93.5.2019
23. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. HP Brezinschek RI Brezinschek PE Lipsky, J Immunol 1995 155 190 202 7602095
24. +B cells. HP Brezinschek SJ Foster RI Brezinschek T Dörner R Domiati-Saad PE Lipsky, J Clin Invest 1997 99 10 2488 2501 9153293 10.1172/JCI119433
25. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. P Kraj DF Friedman F Stevenson LE Silberstein, J Immunol 1995 154 12 6406 6420 7759877
26. Large-scale analysis of human heavy chain V(D)J recombination patterns. J Volpe T Kepler, Immunome Res 2008 4 3 18304322 10.1186/1745-7580-4-3
27. The I binding specificity of human VH4-34 (VH4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3. Y Li MB Spellerberg FK Stevenson JD Capra KN Potter, J Mol Biol 1996 256 3 577 589 10.1006/jmbi.1996.0110 8604140
28. Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs. KN Potter Y Li JD Capra, J Immunol 1996 157 7 2982 2988 8816406
29. Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-Fas(lpr) mice. AJ Feeney BR Lawson DH Kono AN Theofilopoulos, J Immunol 2001 167 6 3486 3493 11544342
30. Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice. IF Robey M Peterson MS Horwitz DH Kono T Stratmann AN Theofilopoulos N Sarvetnick L Teyton AJ Feeney, J Immunol 2004 172 7 4624 4629 15034081
31. Codon bias and plasticity in immunoglobulins. TB Kepler, Mol Biol Evol 1997 14 637 643 9190065
32. Codon bias targets mutation. S Wagner C Milstein M Neuberger, Nature 1995 376 732 732 10.1038/376732a0 7651532
33. Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion. Y Miura CC Chu DM Dines SE Asnis RA Furie N Chiorazzi, Mol Med 2003 9 5-8 166 174 14571324
34. SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations. JM Volpe LG Cowell TB Kepler, Bioinformatics 2006 22 4 438 444 10.1093/bioinformatics/btk004 16357034