Localization determines function: N-terminally truncated NS5A fragments accumulate in the nucleus and impair HCV replication

Journal of Hepatology

Volumn 50, Issue 5, 2009, Pages 861-871

  Sauter, Daniel ^a   Himmelsbach, Kiyoshi ^a   Kriegs, Malte ^a,b   Carvajal Yepes, Monica ^a,c   Hildt, Eberhard ^a,c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Hepatitis C virus; NS5A; Regulatory protein; Signal transduction

Indexed keywords

CASPASE; NONSTRUCTURAL PROTEIN 5A; RAF PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL FRACTIONATION; CELL NUCLEUS; CONFOCAL MICROSCOPY; ENDOPLASMIC RETICULUM; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIFE CYCLE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; PROTEIN SYNTHESIS REGULATION; REPLICON; SIGNAL TRANSDUCTION; VIRUS INACTIVATION; VIRUS REPLICATION;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL NUCLEUS; HEPACIVIRUS; HUMANS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS C-RAF; REPLICON; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 64549120119     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.11.024     Document Type: Article

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