In vitro regulation of proliferation and differentiation within a postnatal growth plate of the cranial base by parathyroid hormone-related peptide (PTHrP)

Journal of Cellular Physiology

Volumn 219, Issue 3, 2009, Pages 688-697

  Wealthall, Rosamund J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; ALKALINE PHOSPHATASE; COLLAGEN TYPE 10; CYCLIC AMP DEPENDENT PROTEIN KINASE; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR; TRANSCRIPTION FACTOR RUNX2; PARATHYROID HORMONE RECEPTOR 1; PRIMER DNA;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ETHMOID BONE; GENE EXPRESSION; HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; MINERALIZATION; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SKULL BASE; ANIMAL; BONE MARROW CELL; BONE MINERALIZATION; CYTOLOGY; DRUG EFFECT; GENETICS; GROWTH PLATE; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PHYSIOLOGY; TISSUE CULTURE TECHNIQUE;

ALKALINE PHOSPHATASE; ANIMALS; BASE SEQUENCE; BONE MARROW CELLS; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA PRIMERS; ETHMOID BONE; GENE EXPRESSION; GROWTH PLATE; MICE; OSTEOBLASTS; PARATHYROID HORMONE-RELATED PROTEIN; RECEPTOR, PARATHYROID HORMONE, TYPE 1; SKULL BASE; TISSUE CULTURE TECHNIQUES;

EID: 64549098204     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21716     Document Type: Article

References (60)

1. Abou-Samra A-B, Jüppner H, Force T, Freeman MW, Kong X-F, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT, Jr., Kronenberg HM, Segre GV. 1992. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736.
2. Adams SL, Cohen AJ, Lassová L. 2007. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. J Cell Physiol 213:635-641. (Pubitemid 350058255)
3. Anderson HC, Sipe JB, Hessle L, Dhanyamraju R, Atti E, Camacho NP, Millan JL. 2004. Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Am J Pathol 164:841-847. (Pubitemid 38235466)
4. Ballock RT, O'Keefe RJ. 2003. Physiology and pathophysiology of the growth plate. Birth Defects Res C Embryo Today 69:123-143. (Pubitemid 37238405)
5. Bancroft JD, Gamble M. 2008. Theory and practice of histological techniques. Edinburgh: Churchill Livingstone.
6. Chan GK, Miao D, Deckelbaum R, Bolivar I, Karaplis A, Goltzman D. 2003. Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T1/2 mesenchymal cells. Endocrinology 144:5511-5520. (Pubitemid 37476081)
7. Chen L, Li C, Qiao W, Xu X, Deng C. 2001. A Ser365!Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Hum Mol Genet 10:457-465. (Pubitemid 32181668)
8. Chen X, Macica CM, Dreyer BE, Hammond VE, Hens JR, Philbrick WM, Broadus AE. 2006. Initial characterization of PTH-related protein gene-driven lacZ expression in the mouse. J Bone Miner Res 21:113-123. (Pubitemid 43023233)
9. Chen X, Macica C, Nasiri A, Judex S, Broadus AE. 2007. Mechanical regulation of PTHrP expression in entheses. Bone 41:752-759. (Pubitemid 47576843)
10. Copray JC, Duterloo HS. 1986. A comparative study on the growth of craniofacial cartilages in vitro. Eur J Orthod 8:157-166.
11. Dabovic B, Chen Y, Colarossi C, Obata H, Zambuto L, Perle MA, Rifkin DB. 2002. Bone abnormalities in latent TGF-β binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-β bioavailability. J Cell Biol 156:227-232. (Pubitemid 34839904)
12. Enomoto H, Enomoto-Iwamoto M, Iwamoto M, Nomura S, Himeno M, Kitamura Y, Kishimoto T, Komori T. 2000. Cbfa1 is a positive regulatory factor in chondrocyte maturation. J Biol Chem 275:8695-8702. (Pubitemid 30180221)
13. Farquharson C, Jefferies D, Seawright E, Houston B. 2001. Regulation of chondrocyte terminal differentiation in the postembryonic growth plate: The role of the PTHrP-Indian hedgehog axis. Endocrinology 142:4131-4140. (Pubitemid 32802686)
14. Gakunga PT, Kuboki Y, Opperman LA. 2000. Hyaluronan is essential for the expansion of the cranial base growth plates. J Craniofac Genet Dev Biol 20:53-63.
15. Garimella R, Bi X, Camacho N, Sipe JB, Anderson HC. 2004. Primary culture of rat growth plate chondrocytes: An in vitro model of growth plate histotype, matrix vesicle biogenesis and mineralization. Bone 34:961-970. (Pubitemid 38749233)
16. Gerstenfeld L, Landis W. 1991. Gene expression and extracellular matrix ultrastructure of a mineralizing chondrocyte cell culture system. J Cell Biol 112:501-513. (Pubitemid 21926004)
17. Gillespie MT, Martin TJ. 1994. The parathyroid hormone-related protein gene and its expression. Mol Cell Endocrinol 100:143-147. (Pubitemid 24109541)
18. Goltzman D. 2008. Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone. Arch Biochem Biophys 473:218-224.
19. Guo J, Chung U-I, Kondo H, Bringhurst FR, Kronenberg HM. 2002. The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating Phospholipase C. Dev Cell 3:183-194.
20. Guo J, Chung U-I, Yang D, Karsenty G, Bringhurst FR, Kronenberg HM. 2006. PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Dev Biol 292:116-128.
21. Harrington EK, Lunsford LE, Svoboda KK. 2004. Chondrocyte terminal differentiation, apoptosis, and type X collagen expression are downregulated by parathyroid hormone. Anat Rec 281A:1286-1295. (Pubitemid 39602110)
22. Harrington EK, Roddy GW, West R, Svoboda KKH. 2007. Parathyroid hormone/parathyroid hormone-related peptide modulates growth of avian sternal cartilage via chondrocytic proliferation. Anat Rec 290:155-167. (Pubitemid 46407081)
23. Horton WA, Hall JG, Hecht JT. 2007. Achondroplasia. Lancet 370:162-172.
24. Ionescu AM, Schwarz EM, Vinson C, Puzas JE, Rosier R, Reynolds PR, O'Keefe RJ. 2001. PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling. J Biol Chem 276:11639-11647. (Pubitemid 37385316)
25. Ishii-Suzuki M, Suda N, Yamazaki K, Kuroda T, Senior PV, Beck F, Hammond VE. 1999. Differential responses to parathyroid hormone-related protein (PTHrP) deficiency in the various craniofacial cartilages. Anat Rec 255:452-457. (Pubitemid 29357762)
26. Ishizuya T, Yokose S, Hori M, Noda T, Suda T, Yoshiki S, Yamaguchi A. 1997. Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells. J Clin Invest 99:2961-2970. (Pubitemid 27278673)
27. Isogai Y, Akatsu T, Ishizuya T, Yamaguchi A, Hori M, Takahashi N, Suda T. 1996. Parathyroid hormone regulates osteoblast differentiation positively or negatively depending on the differentiation stages. J Bone Miner Res 11:1384-1393. (Pubitemid 26330991)
28. Iwamoto M, Jikko A, Murakami H, Shimazu A, Nakashima K, Takigawa M, Baba H, Suzuki F, Kato Y. 1994. Changes in parathyroid hormone receptors during chondrocyte cytodifferentiation. J Biol Chem 269:17245-17251. (Pubitemid 24204049)
29. Jobert AS, Zhang P, Couvineau A, Bonaventure J, Roume J, Le Merrer M, Silve C. 1998. Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. J Clin Invest 102:34-40. (Pubitemid 28323827)
30. Jongen JW, Willemstein-van Hove EC, van der Meer JM, Bos MP, Jüppner H, Segre GV, Abou-Samra AB, Feyen JH, Herrmann-Erlee MP. 1996. Down-regulation of the receptor for parathyroid hormone (PTH) and PTH-related peptide by PTH in primary fetal rat osteoblasts. J Bone Miner Res 11:1218-1225. (Pubitemid 26282521)
31. Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF, Jr., Hock J, Potts JT, Jr., Kronenberg HM, Segre GV. 1991. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1026. (Pubitemid 21917436)
32. Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, Mulligan RC. 1994. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 8:277-289. (Pubitemid 24065970)
33. Kim IS, Otto F, Zabel B, Mundlos S. 1999. Regulation of chondrocyte differentiation by Cbfa1. Mech Dev 80:159-170. (Pubitemid 29125427)
34. Kindblom J, Nilsson O, Hurme T, Ohlsson C, Savendahl L. 2002. Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. J Endocrinol 174:R1-R6. (Pubitemid 34965776)
35. Koyama E, Young B, Nagayama M, Shibukawa Y, Enomoto-Iwamoto M, Iwamoto M, Maeda Y, Lanske B, Song B, Serra R, Pacifici M. 2007. Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development 134:2159-2169. (Pubitemid 46979802)
36. Kronenberg HM. 2003. Developmental regulation of the growth plate. Nature 423:332-336. (Pubitemid 40852707)
37. Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LHK, Ho C, Mulligan RC, Abou-Samra A-B, Jüppner H, Segre GV, Kronenberg HM. 1996. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273:663-666. (Pubitemid 26262123)
38. Li T-F, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. 2004. Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Exp Cell Res 299:128-136. (Pubitemid 39078388)
39. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M. 2008. Endochondral ossification: How cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol 40:46-62. (Pubitemid 350052658)
40. Macsai CE, Foster BK, Xian CJ. 2008. Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair. J Cell Physiol 215:578-587.
41. Magee C, Nurminskaya M, Faverman L, Galera P, Linsenmayer TF. 2005. SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes. J Biol Chem 280:25331-25338. (Pubitemid 40962235)
42. Martin TJ. 2005. Osteoblast-derived PTHrP is a physiological regulator of bone formation. J Clin Invest 115:2322-2324. (Pubitemid 41266192)
43. Miao D, Scutt A. 2002. Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage. J Histochem Cytochem 50:333-340. (Pubitemid 34171058)
44. Miao D, Tong X-K, Chan GK, Panda D, McPherson PS, Goltzman D. 2001. Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem 276:32204-32213. (Pubitemid 37384884)
45. Nagayama M, Iwamoto M, Hargett A, Kamiya N, Tamamura Y, Young B, Morrison T, Takeuchi H, Pacifici M, Enomoto-Iwamoto M, Koyama E. 2008. Wnt/{beta}-catenin signaling regulates cranial base development and growth. J Dent Res 87:244-249.
46. Othman H, Thonar EJ, Mao JJ. 2007. Modulation of neonatal growth plate development by ex vivo intermittent mechanical stress. J Biomech 40:2686-2693. (Pubitemid 47241238)
47. Perlyn CA, DeLeon VB, Babbs C, Govier D, Burell L, Darvann T, Kreiborg S, Morriss-Kay G. 2006. The craniofacial phenotype of the Crouzon mouse: Analysis of a model for syndromic craniosynostosis using three-dimensional MicroCT. Cleft Palate Craniofac J 43:740-748. (Pubitemid 44788781)
48. Riemer S, Gebhard S, Beier F, Pöschl E, von der Mark K. 2002. Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: Localization of a PTH/PTHrP-responsive region in the human COL10A1 enhancer. J Cell Biochem 86:688-699. (Pubitemid 34839970)
49. Rodriguez L, Cheng Z, Chen T-H, Tu C, Chang W. 2005. Extracellular calcium and parathyroid hormone-related peptide signaling modulate the pace of growth plate chondrocyte differentiation. Endocrinology 146:4597-4608. (Pubitemid 41446597)
50. Schipani E, Provot S. 2003. PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development. Birth Defects Res C Embryo Today 69:352-362. (Pubitemid 38076458)
51. Schipani E, Kruse K, Jüppner H. 1995. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 268:98-100.
52. Schwartz Z, Semba S, Graves D, Dean DD, Sylvia VL, Boyan BD. 1997. Rapid and long-term effects of PTH(1-34) on growth plate chondrocytes are mediated through two different pathways in a cell-maturation-dependent manner. Bone 21:249-259.
53. Serra R, Karaplis A, Sohn P. 1999. Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation. J Cell Biol 145:783-794. (Pubitemid 29240855)
54. Shum L, Wang X, Kane AA, Nuckolls GH. 2003. BMP4 promotes chondrocyte proliferation and hypertrophy in the endochondral cranial base. Int J Dev Biol 47:423-431. (Pubitemid 37362473)
55. Suda N, Gillespie MT, Traianedes K, Zhou H, Ho PW, Hards DK, Allan EH, Martin TJ, Moseley JM. 1996. Expression of parathyroid hormone-related protein in cells of osteoblast lineage. J Cell Physiol 166:94-104. (Pubitemid 26017783)
56. Susperregui ARG, Viñals F, Ho PWM, Gillespie MT, Martin TJ, Ventura F. 2008. BMP-2 regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells. J Cell Physiol 216:144-152.
57. Tawfeek HAW, Abou-Samra AB. 2008. Negative regulation of parathyroid hormone (PTH)-activated phospholipase C by PTH/PTH-related peptide receptor phosphorylation and protein kinase A. Endocrinology 149:4016-4023.
58. Thomas D, Sunters A, Gentry A, Grigoriadis A. 2000. Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene. J Cell Sci 113:439-450. (Pubitemid 30116650)
59. Ueta C, Iwamoto M, Kanatani N, Yoshida C, Liu Y, Enomoto-Iwamoto M, Ohmori T, Enomoto H, Nakata K, Takada K, Kurisu K, Komori T. 2001. Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol 153:87-100. (Pubitemid 34280196)
60. van der Eerden BC, Karperien M, Gevers EF, Lowik CW, Wit JM. 2000. Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: Evidence for a locally acting growth restraining feedback loop after birth. J Bone Miner Res 15:1045-1055. (Pubitemid 30350067)