Wnt/β-catenin signaling regulates cranial base development and growth

Journal of Dental Research

Volumn 87, Issue 3, 2008, Pages 244-249

  Nagayama, M ^a,b   Iwamoto, M ^a   Hargett, A ^a   Kamiya, N ^c   Tamamura, Y ^a   Young, B ^a   Morrison, T ^a   Takeuchi, H ^b   Pacifici, M ^a   Enomoto Iwamoto, M ^a   Koyama, E ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b ASAHI UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cranial base synchondrosis; Hedgehog signaling; PTHrP; sFRP 1; Wnt catenin

Indexed keywords

BETA CATENIN; COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 2; IHH PROTEIN, MOUSE; LEF1 PROTEIN, MOUSE; LYMPHOID ENHANCER FACTOR 1; MEMBRANE PROTEIN; OSTERIX PROTEIN, MOUSE; PARATHYROID HORMONE RELATED PROTEIN; SFRP1 PROTEIN, MOUSE; SIGNAL PEPTIDE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN; ZINC FINGER PROTEIN;

ANIMAL; ARTICLE; BONE DEVELOPMENT; CARTILAGE; CARTILAGE CELL; CRANIAL SUTURE; GENETIC TRANSCRIPTION; GENETICS; GROWTH PLATE; GROWTH, DEVELOPMENT AND AGING; HYPERTROPHY; MOUSE; MUTATION; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKULL BASE; TRANSGENIC MOUSE;

ANIMALS; BETA CATENIN; CARTILAGE; CHONDROCYTES; COLLAGEN TYPE I; COLLAGEN TYPE II; COLLAGEN TYPE X; CRANIAL SUTURES; GROWTH PLATE; HEDGEHOG PROTEINS; HYPERTROPHY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOID ENHANCER-BINDING FACTOR 1; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; OSTEOGENESIS; PARATHYROID HORMONE-RELATED PROTEIN; SIGNAL TRANSDUCTION; SKULL BASE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; WNT PROTEINS; ZINC FINGERS;

EID: 41149142409     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910808700309     Document Type: Article

References (35)

1. Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, et al. (2001). Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128:1253-1264.
2. Church V, Nohno T, Linker C, Marcelle C, Francis-West P (2002). Wnt regulation of chondrocyte differentiation. J Cell Sci 115:4809-4818.
3. DasGupta R, Fuchs E (1999), Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126:4557-4568.
4. Day TF, Guo X, Garrett-Beal L, Yang Y (2005). Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8:739-750.
5. Eastman Q, Grosschedl R (1999). Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr Opin Cell Biol 11:233-240.
6. Enomoto-Iwamoto M, Kitagaki J, Koyama E, Tamamura Y, Wu C, Kanatani N, et al. (2002), The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis. Dev Biol 251:142-156.
7. Gaur T, Rich L, Lengner CJ, Hussain S, Trevant B, Ayers D, et al. (2006). Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation. J Cell Physiol 208:87-96.
8. Hartmann C, Tabin CJ (2001). Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton. Cell 104:341-351.
9. He J, Sheng T, Stelter AA, Li C, Zhang X, Sinha M, et al. (2006). Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J BiolChem 281:35598-35602.
10. Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C (2005). Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8:727-738.
11. Hu H, Hilton MJ, Tu X, Yu K, Omitz DM, Long F (2005). Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132:49-60.
12. Huelsken J, Birchmeier W (2001). New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 11:547-553.
13. Ingeivall B, Thilander B (1972). The human spheno-occipital synchondrosis. I. The time of closure appraised macroscopically, Acta Odontol Scand 30:349-356.
14. Kjaer I (1990). Radiographic determination of prenatal basicranial ossification. J Craniofac Genet Dev Biol 10:113-123.
15. Koyama E, Leatherman JL, Noji S, Pacifici M (1996). Early chick limb cartilaginous elements possess polarizing activity and express Hedgehog-related morphogenetic factors. Dev Dyn 207:344-354.
16. Koyama E, Young B, Nagayama M, Shibukawa Y, Enomoto-Iwamoto M, Iwamoto M, et al. (2007). Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development 134:2159-2169.
17. Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, et al. (1996). PTH/PTHrP receptor in early development and Indian hedgehogregulated bone growth. Science 273:663-666.
18. Lieberman DE, McCarthy RC (1999). The ontogeny of cranial base angulation in humans and chimpanzees and its implications for reconstructing pharyngeal dimensions. J Hum Evol 36:487-517.
19. Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP (2004). Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131:1309-1318.
20. Miller JR, Hocking AM, Brown JD, Moon RT (1999). Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways. Oncogene 18:7860-7872.
21. Mooney MP, Losken HW, Tschakaloff A, Siegel MI, Losken A, Lalikos JF (1993). Congenital bilateral coronal suture synostosis in a rabbit and craniofacial growth comparisons with experimental models. Cleft Palate Craniofac J 30:121-128.
22. Nakamura T, Aikawa T, Iwamoto-Enomoto M, Iwamoto M, Higuchi Y, Pacifici M, et al. (1997), Induction of osteogenic differentiation by hedgehog proteins. Biochem Biophys Res Commun 237:465-469; erratum in Biochem Biophys Res Commun 247:910, 1998.
23. Nusse R, Varmus HE (1992). Wnt genes. Cell 69:1073-1087.
24. Roberts GJ, Blackwood HJ (1983), Growth of the cartilages of the mid-line cranial base: a radiographic and histological study. J Anat 136:307-320.
25. Rodda SJ, McMahon AP (2006). Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133:3231-3244.
26. Shibukawa Y, Young B, Wu C, Yamada S, Long F, Pacifici M, et al. (2007). Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn 236:426-434.
27. Spater D, Hill TP, O'Sullivan RJ, Gruber M, Conner DA, Hartmann C (2006). Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis, Development 133:3039-3049.
28. Sperber GH (2001). Cranial base. In: Craniofacial development. Hamilton, Canada: B.C. Decker, pp. 89-101.
29. St-Jacques B, Hammerschmidt M, McMahon AP (1999). Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13:2072-2086; erratum in Genes Dev 13:2617, 1999.
30. Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, et al. (2005). Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem 280:19185-19195.
31. Thorogood P (1988). The developmental specification of the vertebrate skull. Development 103(Suppl):141-153.
32. Veeman MT, Axelrod JD, Moon RT (2003). A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 5:367-377.
33. Wang FS, Lin CL, Chen YJ, Wang CJ, Yang KD, Huang YT, et al. (2005). Secreted frizzled-related protein 1 modulates glucocorticoid attenuation of osteogenic activities and bone mass. Endocrinology 146:2415-2423.
34. Yang Y, Topol L, Lee H, Wu J (2003). Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development 130:1003-1015.
35. Young B, Minugh-Purvis N, Shimo T, St-Jacques B, Iwamoto M, Enomoto-Iwamoto M, et al. (2006). Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Dev Biol 299:272-282.