Comparative inhibitory activities of sulforaphane and phenethyl isothiocyanate against leukemia resistant CEM/C2 cancer cells

Journal of Functional Foods

Volumn 1, Issue 2, 2009, Pages 229-235

  Losso, Jack N ^a   Truax, Robert E ^a  

^a LOUISIANA STATE UNIVERSITY AGRICULTURAL CENTER   (United States)

Author keywords

Angiogenesis; CEM C2 cells; Functional foods; Leukemia; Phenethyl isothiocyanate; Sulforaphane

Indexed keywords

EID: 64349104730     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2009.02.003     Document Type: Article

References (24)

1. Bertl E., Bartsch H., and Gerhäuser C. Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention. Molecular Cancer Therapeutics 5 (2006) 575-585
2. Chiao J.W., Chung F.L., Kancherla R., Ahmed T., Mittelman A., and Conaway C.C. Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. International Journal of Oncology 20 (2002) 1-6
3. Conaway C.C., Jiao D., and Chung F.L. Inhibition of rat liver cytochrome P450 isozymes by isothiocyanates and their conjugates: a structure-activity relationship study. Carcinogenesis 17 (1996) 2423-2427
4. Dinkova-Kostova A.T., and Talalay P. Direct and indirect antioxidant properties of 15 inducers of cytoprotective proteins. Molecular Nutrition and Food Research 52 (2008) S128-S138
5. García A., Haza A.I., Arranz N., Rafter J., and Morales P. Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. Journal of Applied Toxicology 28 (2008) 196-204
6. Guo L., Liu X., Nishikawa K., and Plunkett W. Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials. Molecular Cancer Therapeutics 6 (2007) 1501-1508
7. Hanlon N., Coldham N., Gielbert A., Kuhnert N., Sauer M.J., King L.J., and Ioannides C. Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat. British Journal of Nutrition 10 (2007) 1-6
8. Higdon J.V., Delage B., Williams D.E., and Dashwood R.H. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacological Research 55 (2007) 224-236
9. Hwang E.S., and Jeffery E.H. Evaluation of urinary N-acetyl cysteinyl allyl isothiocyanate as a biomarker for intake and bioactivity of Brussels sprouts. Food and Chemical Toxicology 41 (2003) 1817-1825
10. Hwang E.S., and Lee H.J. Phenylethyl isothiocyanate and its N-acetylcysteine conjugate 40 suppress the metastasis of SK-Hep1 human hepatoma cells. Journal of Nutritional Biochemistry 17 (2006) 837-846
11. Ishizaki, H, Brady, J. F, Ning, S. M, & Yang, C. S. (1990). Effect of phenethyl isothiocyanate on microsomal N-nitrosodimethylamine metabolism and other monooxygenase activities. 45 Xenobiotica, 20, 255-264.
12. Jackson S.J., and Singletary K.W. Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization. Journal of Nutrition 134 (2004) 2229-2236
13. Jeffery E.H., and Keck A.S. Translating knowledge generated by epidemiological and in 5 vitro studies into dietary cancer prevention. Molecular Nutrition and Food Research 10 (2008) 7-17
14. Lai R.H., Keck A.S., Wallig M.A., West L.G., and Jeffery E.H. Evaluation of the safety and bioactivity of purified and semi-purified glucoraphanin. Food and Chemical Toxicology 46 (2008) 195-202
15. Mennicke W.H., Görler K., and Krumbiegel G. Metabolism of some naturally occurring isothiocyanates in the rat. Xenobiotica 13 (1983) 203-207
16. Pappa G., Bartsch H., and Gerhäuser C. Biphasic modulation of cell proliferation by 15 sulforaphane at physiologically relevant exposure times in a human colon cancer cell line. Molecular Nutrition and Food Research 51 (2007) 977-984
17. Parnaud G., Li P., Cassar G., Rouimi P., Tulliez J., Combaret L., and Gamet-Payrastre L. Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon 20 cancer cells. Nutrition and Cancer-An International Journal 48 (2004) 198-206
18. Prestera T., and Talalay P. Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. Proceedings of the National Academy of Sciences of the United States of America 92 (1995) 8965-8969
19. Qanungo S., Wang M., and Nieminen A.L. N-Acetyl-l-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts. Journal of Biological Chemistry 279 (2004) 50455-50464
20. Saitoh Y., Yamamoto N.M., Dewan Z., Sugimoto H., Martinez Bruyn V.J., Iwasaki Y., Matsubara K., Qi X., Saitoh T., Imoto I., Inazawa J., Utsunomiya A., Watanabe T., Masuda T., Yamamoto N., and Yamaoka S. Overexpressed NF-B-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Blood 111 (2008) 5118-5129
21. Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat Med. 10 (2004) 789-799
22. Yao H., Wang H., Zhang Z., Jiang B.H., Luo J., and Shi X. Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells. International Journal of Cancer 123 (2008) 1255-1261
23. Zhang, Y., Talalay, P., Cho, C. G., & Posner, G. H. (1992). A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proceedings of the National Academy of Sciences of the United States of America, 89, 2399-2403.
24. Zhu M., Zhang Y., Cooper S., Sikorski E., Rohwer J., and Bowden G.T. Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism. Molecular Carcinogenesis 41 (2004) 179-186