Evaluation of the safety and bioactivity of purified and semi-purified glucoraphanin

Food and Chemical Toxicology

Volumn 46, Issue 1, 2008, Pages 195-202

  Lai, R H ^a   Keck, A S ^a   Wallig, M A ^a   West, L G ^b   Jeffery, E H ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b Kraft Foods Global Inc   (United States)

Author keywords

Bioactivity; Cecal inflammation; Ethoxyresorufin O deethylase; Glucoraphanin; NAD(P)H quinone oxidoreductase; Safety

Indexed keywords

ANTINEOPLASTIC AGENT; ETHOXYRESORUFIN DEETHYLASE; GLUCORAPHANIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; ENZYME ACTIVITY; HISTOPATHOLOGY; MALE; NONHUMAN; RAT; URINARY EXCRETION;

ANIMALS; ANTICARCINOGENIC AGENTS; BRASSICA; CECUM; COLON; CYTOCHROME P-450 CYP1A1; CYTOSOL; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; GLUCOSINOLATES; IMIDOESTERS; LIVER; LUNG; MALE; MICROSOMES; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; RATS; RATS, INBRED F344; SEEDS;

BRASSICA OLERACEA VAR. ITALICA; RATTUS;

EID: 36849026035     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.07.015     Document Type: Article

References (27)

1. Barillari J., Gueyrard D., Rollin P., and Iori R. Barbarea verna as a source of 2-phenylethyl glucosinolate, precursor of cancer chemopreventive phenylethyl isothiocyanate. Fitoterapia 72 (2001) 760-764
2. Barker C.W., Fagan J.B., and Pasco D.S. Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress. J. Biol. Chem. 269 (1994) 3985-3990
3. Bheemreddy R.M., and Jeffery E.H. The metabolic fate of purified glucoraphanin in F344 rats. J. Agric. Food Chem. 55 (2007) 2861-2866
4. Bones A.M., and Rossiter J.T. The enzymic and chemically induced decomposition of glucosinolates. Phytochemistry 67 (2006) 1053-1067
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
6. Canistro D., Croce C.D., Iori R., Barillari J., Bronzetti G., Poi G., Cini M., Caltavuturo L., Perocco P., and Paolini M. Genetic and metabolic effects of gluconasturtiin, a glucosinolate derived from cruciferae. Mutat. Res. 545 (2004) 23-35
7. Cohen J.H., Kristal A.R., and Stanford J.L. Fruit and vegetable intakes and prostate cancer risk. J. Natl. Cancer Inst. 92 (2000) 61-68
8. Engel E., Baty C., Le Corre D., Souchon I., and Martin N. Flavor-active compounds potentially implicated in cooked cauliflower acceptance. J. Agric. Food Chem. 50 (2002) 6459-6467
9. Fenwick G.R., Heaney R.K., and Mullin W.J. Glucosinolates and their breakdown products in food and food plants. Crit. Rev. Food Sci. Nutr. 18 (1983) 123-201
10. Fowke J.H., Fahey J.W., Stephenson K.K., and Hebert J.R. Using isothiocyanate excretion as a biological marker of Brassica vegetable consumption in epidemiological studies: evaluating the sources of variability. Public Health Nutr. 4 (2001) 837-846
11. Getahun S.M., and Chung F.L. Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress. Cancer Epidemiol. Biomar. Prev. 8 (1999) 447-451
12. Haschek W.M., Rousseaux C.G., and Wallig M.A. Gastrointestinal Tract. In: Haschek W.M., Rousseaux C.G., and Wallig M.A. (Eds). Fundamentals of Toxicologic Pathology. First ed. (1998), Academic Press, San Diego, CA 57-89
13. Heiss E., Herhaus C., Klimo K., Bartsch H., and Gerhauser C. Nuclear factor κB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J. Biol. Chem. 276 (2001) 32008-32015
14. Holtzclaw W.D., Dinkova-Kostova A.T., and Talalay P. Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers. Adv. Enzyme Regul. 44 (2004) 335-367
15. Iori R., Bernardi R., Gueyrard D., Rollin P., and Palmieri S. Formation of glucoraphanin by chemoselective oxidation of natural glucoerucin: a chemoenzymatic route to sulforaphane. Bioorg. Med. Chem. Lett. 9 (1999) 1047-1048
16. Keck A.S., Qiao Q., and Jeffery E.H. Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of F344 rats. J. Agric. Food Chem. 51 (2003) 3320-3327
17. Kushad M.M., Brown A.F., Kurilich A.C., Juvik J.A., Klein B.P., Wallig M.A., and Jeffery E.H. Variation of glucosinolates in vegetable crops of Brassica oleracea. J. Agric. Food Chem. 47 (1999) 1541-1548
18. Maheo K., Morel F., Langouet S., Kramer H., Le Ferrec E., Ketterer B., and Guillouzo A. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 57 (1997) 3649-3652
19. Paolini M., Perocco P., Canistro D., Valgimigli L., Pedulli G.F., Iori R., Croce C.D., Cantelli-Forti G., Legator M.S., and Abdel-Rahman S.Z. Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming and DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli. Carcinogenesis 25 (2004) 61-67
20. Parnaud G., Li P., Cassar G., Rouimi P., Tulliez J., Combaret L., and Gamet-Payrastre L. Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells. Nutr. Cancer. 48 (2004) 198-206
21. Prochaska H.J., and Santamaria A.B. Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers. Anal. Biochem. 169 (1988) 328-336
22. Rouzaud G., Rabot S., Ratcliffe B., and Duncan A.J. Influence of plant and bacterial myrosinase activity on the metabolic fate of glucosinolates in gnotobiotic rats. Brit. J. Nutr. 90 (2003) 395-404
23. Steinmetz K.A., and Potter J.D. Vegetables, fruit, and cancer prevention: a review. J. Am. Diet. Assoc. 96 (1996) 1027-1039
24. Verhoeven D.T., Goldbohm R.A., van Poppel G., Verhagen H., and van den Brandt P.A. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol. Biomar. Prev. 5 (1996) 733-748
25. West L., Tsui I., and Haas G. Single column approach for the liquid chromatographic separation of polar and non-polar glucosinolates from broccoli sprouts and seeds. J. Chromatogr. A 966 (2002) 227-232
26. Yu X., and Kensler T. Nrf2 as a target for cancer chemoprevention. Mutat. Res. 591 (2005) 93-102
27. Zhang Y., Talalay P., Cho C.G., and Posner G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 2399-2403