Effects of α-lipoic acid on transforming growth factor β1-p38 mitogen-activated protein kinase-fibronectin pathway in diabetic nephropathy

Metabolism: Clinical and Experimental

Volumn 58, Issue 5, 2009, Pages 616-623

  Lee, Seong Jin ^a   Kang, Jun Goo ^a   Ryu, Ohk Hyun ^a   Kim, Chul Sik ^a   Ihm, Sung Hee ^a   Choi, Moon Gi ^a   Yoo, Hyung Joon ^a   Kim, Dong Sun ^b   Kim, Tae Wha ^b  

^a Hallym University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; THIOCTIC ACID; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG EFFECT; FOOD INTAKE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT;

ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; BLOTTING, WESTERN; CHOLESTEROL; DIABETIC NEPHROPATHIES; FATTY ACIDS, NONESTERIFIED; FIBRONECTINS; HEMOGLOBIN A, GLYCOSYLATED; INSULIN; MALE; MALONDIALDEHYDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEINURIA; RANDOM ALLOCATION; RATS; RATS, INBRED OLETF; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; THIOCTIC ACID; TRANSFORMING GROWTH FACTOR BETA1;

EID: 64349101086     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2008.12.006     Document Type: Article

References (47)

1. Collart F. Kidney failure, proteinuria, and diabetic nephropathy. Rev Med Brux 24 (2003) A257-A262
2. Kreisberg J.I., Garoni J.A., Radnik R., et al. High glucose and TGFβ1 stimulate fibronectin gene expression through a cAMP response element. Kidney Int 46 (1994) 1019-1024
3. Attisano L., and Wrana J.L. Signal transduction by members of the transforming growth factor-β superfamily. Cytokine Growth Factor Rev 7 (1996) 327-339
4. August P., and Suthanthiran M. Transforming growth factor β signaling, vascular remodeling, and hypertension. N Engl J Med 354 (2006) 2721-2723
5. Border W.A., and Noble N.A. Transforming growth factor β in tissue fibrosis. N Engl J Med 331 (1994) 1286-1292
6. Hayashida T., Poncelet A.C., Hubchak S.C., et al. TGF-β1 activates MAP kinase in human mesangial cells: a possible role in collagen expression. Kidney Int 56 (1999) 1710-1720
7. Border W.A., and Noble N.A. Cytokines in kidney disease: the role of transforming growth factor β. Am J Kidney Dis 22 (1993) 105-113
8. Poncelet A.C., and Schnaper H.W. Regulation of human mesangial cell collagen expression by transforming growth factor-β1. Am J Physiol 275 (1998) F458-F466
9. Yamamoto T., Nakamura T., Noble N.A., et al. Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad U S A 90 (1993) 1814-1818
10. Yagi K., Kim S., Wanibuchi H., et al. Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty Rats. Hypertension 29 (1997) 728-735
11. Shankland S.J., and Scholey J.W. Expression of transforming growth factor-β1 during diabetic renal hypertrophy. Kidney Int 46 (1994) 430-442
12. Hellmich B., Schellner M., Schatz H., et al. Activation of transforming growth factor-β1 in diabetic kidney disease. Metabolism 49 (2000) 353-359
13. Kawano K., Hirashima T., Mori S., et al. Spontaneous long-term hyperglycemic rat with diabetic complications: Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41 (1992) 1422-1428
14. Seger R., and Krebs E.G. The MAPK signaling cascade. FASEB J 9 (1995) 726-798
15. Nishida E., and Gotoh Y. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 18 (1993) 128-131
16. Han J., Lee J.D., Tobias P.S., et al. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265 (1994) 808-811
17. Zu Y.L., Qi J., Gilchrist A., et al. p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation. J Immunol 160 (1998) 1982-1989
18. Dérijard B., Raingeaud J., Barrett T., et al. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267 (1995) 682-685
19. Iordanov M., Bender K., Ade T., et al. CREB is activated by UVC through a p38/HOG-1-dependent protein kinase. EMBO J 16 (1997) 1009-1022
20. Bowlus C.L., McQuillan J.J., and Dean D.C. Characterization of three different elements in the 5′-flanking region of the fibronectin gene which mediate a transcriptional response to cAMP. J Biol Chem 266 (1991) 1122-1127
21. Kang S.W., Adler S.G., Lapage J., et al. p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli. Kidney Int 60 (2001) 543-552
22. Ha H., and Kin K.H. Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C. Diabetes Res Clin Pract 45 (1999) 147-151
23. Wang J., Huang H., Liu P., et al. Inhibition of phosphorylation of p38 MAPK involved in the protection of nephropathy by emodin in diabetic rats. Eur J Pharmacol 553 (2006) 297-303
24. Chin B.Y., Mohsenin A., Li S.X., et al. Stimulation of pro-α1(I) collagen by TGFβ1 in mesangial cells: role of the p38 MAPK pathway. Am J Renal Physiol 280 (2001) F495-F504
25. Hannigan M., Zhan L., Ai Y., et al. The role of p39 MAP kinase in TGF-β1-induced signal transduction in human neutrophils. Biochem Biophys Res Commun 246 (1998) 55-58
26. Kramer I.M., Koornneef I., De Laat S.W., et al. TGFβ1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CC164 cells. EMBO J 10 (1991) 1083-1089
27. Isono M., Chen S., Hong S.W., et al. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells. Biochem Biophys Res Commun 296 (2002) 1356-1365
28. Fujita H., Omori S., Ishikura K., et al. ERK and p38 mediate high-glucose-induced hypertrophy and TGF-β expression in renal tubular cells. Am J Physiol 286 (2004) F120-F126
29. Gruden G., Zonca S., Hayward A., et al. Mechanical stretch-induced fibronectin and transforming growth factor-beta1 production in human mesangial cells is p38 MAPK-dependent. Diabetes 49 (2000) 655-661
30. Paker L., Witt E.H., and Tritschler J.H. Alpha lipoic acid as a biological antioxidant. Free Radic Biol Med 19 (1995) 227-250
31. Song K.H., Lee W.J., Koh J.M., et al. Alpha-lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun 326 (2005) 197-202
32. Lee W.J., Song K.H., Koh E.H., et al. Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun 332 (2005) 885-891
33. Kim M.S., Park J.Y., Namkoong C., et al. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 10 (2004) 727-733
34. Melhem M.F., Craven P.A., and DeRubertis F.R. Effects of dietary supplementation of α-lipoic acid on early glomerular injury in diabetes. J Am Soc Nephrol 12 (2001) 124-133
35. Melhem M.F., Craven P.A., Liachenko J., et al. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol 13 (2002) 108-116
36. Morcos M., Borcea V., Isermann B., et al. Effect of α-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. Diabetes Res Clin Pract 52 (2001) 175-183
37. Budisavljevic M.N., Hodge L., Barber K., et al. Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. Am J Physiol Renal Physiol 285 (2003) F1138-F1148
38. Catherwood M.A., Powell L.A., Anderson P., et al. Glucose-induced oxidative stress in mesangial cells. Kidney Int 61 (2002) 599-608
39. Hnia K., Hugon G., Rivier F., et al. Modulation of p38 mitogen-activated protein kinase cascade and metalloproteinase activity in diaphragm muscle in response to free radical scavenger administration in dystrophin-deficient Mdx mice. Am J Pathol 170 (2007) 633-643
40. Sato T., Asahi Y., Toide K., et al. Insulin resistance in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a new model of NIDDM. Diabetologia 38 (1995) 1033-1041
41. Ziyadeh F.N., Hoffman B.B., Han D.C., et al. Long-term prevention of renal insufficiency, excess matrix gene expression and glomerular mesangial matrix expression by treatment with monoclonal anti-TGF-β antibody in db/db diabetic mice. Proc Natl Acad U S A 97 (2000) 8015-8020
42. Chen S., Iglesias-de la Cruz M.C., Jim B., et al. Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice. Biochem Biophys Res Commun 300 (2003) 16-22
43. Oksala N.K., Lappalainen J., Laaksonen D.E., et al. Alpha-lipoic acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney. Antioxid Redox Signal 9 (2007) 497-506
44. Furuse Y., Hashimoto N., Maekawa M., et al. Activation of the Smad pathway in glomeruli from a spontaneously diabetic rat model, OLETF rats. Nephron Exp Nephrol 98 (2004) e100-e108
45. McKay N.G., Khong T.F., Haites N.E., et al. The effect of transforming growth factor-β1 on mesangial cell fibronectin synthesis: increased incorporation into the extracellular matrix and reduced pI but no effect on alternative splicing. Exp Mol Pathol 59 (1993) 211-224
46. Igarashi M., Wakasaki H., Takahara N., et al. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest 103 (1999) 185-195
47. Wilmer W.A., Dixon C.L., and Herbert C. Chronic exposure of human mesangial cells to high glucose environment activates the p38 MAPK pathway. Kidney Int 60 (2001) 858-871