Activation of the Smad pathway in glomeruli from a spontaneously diabetic rat model, OLETF rats

Nephron - Experimental Nephrology

Volumn 98, Issue 3, 2004, Pages

  Furuse, Yoko ^a   Hashimoto, Naotake ^b   Maekawa, Mamiko ^a   Toyama, Yoshiro ^a   Nakao, Atsuhito ^c   Iwamoto, Itsuo ^a   Sakurai, Kenichi ^a   Suzuki, Yoshifumi ^d   Yagui, Kazuo ^a   Yuasa, Shigeki ^e   Toshimori, Kiyotaka ^a   Saito, Yasushi ^a  

^a CHIBA UNIVERSITY   (Japan)

^b ASAHI GENERAL HOSPITAL   (Japan)

^c UNIVERSITY OF YAMANASHI   (Japan)

^d Matsudo City Hospital   (Japan)

^e NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Diabetic nephropathy; Glomerulus; OLETF; Smads; Transforming growth factor

Indexed keywords

FIBRONECTIN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TGFB1 PROTEIN, RAT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE MODEL; EXPERIMENTAL RAT; GLOMERULUS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL EXPERIMENT; HISTOPATHOLOGY; MESANGIUM; PROTEIN BLOOD LEVEL; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION PROFILING; GENETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BLOTTING, WESTERN; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; FIBRONECTINS; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; KIDNEY GLOMERULUS; MALE; RATS; RATS, INBRED OLETF; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 8344273474     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080685     Document Type: Article

References (32)

1. Mauer SM, Steffes MW, Brown DM: The kidney in diabetes. Am J Med 1981;70:603-612.
2. Steffes MW, Osterby R, Chavers B, Mauer SM: Mesangial expansion as a central loss of kidney function in diabetic patients. Diabetes 1989;38:1077-1081.
3. 1 enhances glomerular collagen synthesis in diabetic rats. Diabetes 1993;42:1673-1677.
4. Pankewycz OG, Guan JX, Bolton WK, Gomez A, Benedict JF: Renal TGF-β regulation in spontaneously diabetic NOD mice with correlations in mesangial cells. Kidney Int 1994;46:748-758.
5. 1 during diabetic renal hypertrophy. Kidney Int 1994;46:430-442.
6. Yamamoto T, Nakamura T, Noble NA, Ruoslahti E, Border WA: Expression of transforming growth factor-β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA1993;90:1814-1818.
7. 1 and fibronectin synthesis. Kidney Int 1998;54:1872-1878.
8. Van Det NF, Verhagen NA, Tamsma JT, Berden JH, Bruijn JA, Daha MR, van der Woude FJ: Regulation of glomerular epithelial cell production of fibronectin and transforming growth factor-β by high glucose, not by angiotensin II. Diabetes 1997;46:834-840.
9. Rocco MV, Chen Y, Goldfarb S, Ziyadeh FN: Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule. Kidney Int 1992;41:107-114.
10. Ziyadeh FN, Sharma K, Ericksen M, Wolf G: Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β. J Clin Invest 1994;93:536-542.
11. 1 regulates mesangial production of heparan sulfate proteoglycan. Am J Physiol 1996;270:F812-F821.
12. 1 induces accumulation of glomerular extracellular matrix in transgenic mice. Diabetes 1999;48:182-192.
13. Graff JM, Bansal A, Melton DA: Xenopus Mad proteins transduce distinct subsets of signals for the TGF-β superfamily. Cell 1996;85:479-487.
14. Heldin CH, Miyazono K, ten Dijke P: TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-471.
15. Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P: TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 1997;16:5353-5362.
16. Chen Y, Bhushan A, Vale W: Smad8 mediates the signaling of the ALK-2 receptor serine kinase. Proc Natl Acad Sci USA 1997;94:12938-12943.
17. Lagna G, Hata A, Hemmati-Brivanlou A, Massague J: Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 1996;383:832-836
18. Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P: Identification of Smad7, a TGF-β-inducible antagonist of TGF-β signalling. Nature 1997;389:631-635.
19. Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T: Spontaneous long-term hyperglycemic rat with diabetic complications, Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 1992;41:1422-1428.
20. Sato T, Asahi Y, Toide K, Nakayama N: Insulin resistance in skeletal muscle of the male Ostuka Long-Evans Tokushima Fatty rat, a new model of NIDDM. Diabetologia 1995;38:1033-1041.
21. Ishida K, Mizuno A, Min Z, Sano T, Shima K: Which is the primary etiologic event in Otsuka Long-Evans Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus, insulin resistance, or impaired insulin secretion? Metabolism 1995;44:940-945.
22. Fukuzawa Y, Watanabe Y, Inaguma D, Hotta N: Evaluation of glomerular lesion and abnormal urinary findings in OLETF rats resulting from a long-term diabetic state. J Lab Clin Med 1996;128:568-578.
23. Seki N, Hashimoto N, Suzuki Y, Mori S, Amano K, Saito Y: The role of SRC homology 2-containing tyrosine phosphatase-2 on proliferation of rat smooth muscle cells. Arterioscler Thromb Vasc Biol 2002;22:1081-1085.
24. Isaka Y, Fujiwara Y, Ueda N, Kaneda Y, Kamada T, Imai E: Glomerulosclerosis induced by in vivo transfection of transforming growth factor-β or platelet-derived growth factor gene into the rat kidney. J Clin Invest 1993;92:2597-2601.
25. Yagi K, Kim S, Wanibuchi H, Yamashita Y, Iwano H: Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats. Hypertension 1997;29:728-735.
26. Kushiro M, Shikata K, Sugimoto H, Ikeda K, Horiuchi S, Makino H: Accumulation of NU-σ(carboxymethyl)lysine and changes in glomerular extracellular matrix components in Otsuka Long-Evans Tokushima Fatty rats: A model of spontaneous NIDDM. Nephron 1998;79:458-468.
27. Isono M, Chen S, Hong SW, Iglesias-de la Cruz MC, Ziyadeh FN: Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells. Biochem Biophys Res Commun 2002;296:1356-1365.
28. 1 in human pancreatic cancer. Dig Dis Sci 1999;44:1793-1802.
29. Tamura K, Kanzaki T, Tashiro J, Yokote K, Mori S, Ueda S, Saito Y, Morisaki N: Increased atherogenesis in Otsuka Long-Evans Tokushima Fatty rats before the onset of diabetes mellitus: Association with overexpression of PDGF β-receptors in aortic smooth muscle cells. Atherosclerosis 2000;149:351-358.
30. Mogensen CE: Microalbumiuria predicts clinical proteinuria and early mortality in maturity onset diabetes. N Engl J Med 1984;310:356-360.
31. Mattock MB, Keen H, Viberti GC, el-Gohari MR, Murrells TJ, Scott GS, Wing JR, Jackson PG: Coronary heart disease and urinary albumin excretion rate in type 2 (non-insulindependent) diabetic patients. Diabetologia 1998;31:82-87.
32. Mykkanen L, Zaccaro DJ, O'Leary DH, Howard G, Robbins DC, Haffner SM: Microalbuminuria and carotid artery intima-media thickness in nondiabetic and NIDDM subjects. The Insulin Resistance Atherosclerosis Study (IRAS). Stroke 1997;28:1710-1716.