-
1
-
-
1242330918
-
-
(a) Angibaud, P. R.; Venet, M. G.; Filliers, W.; Broeckx, R.; Ligny, Y. A.; Muller, P.; Poncelet, V. S.; End, D. W. Eur. J. Org. Chem. 2004, 479.
-
(2004)
Eur. J. Org. Chem
, pp. 479
-
-
Angibaud, P.R.1
Venet, M.G.2
Filliers, W.3
Broeckx, R.4
Ligny, Y.A.5
Muller, P.6
Poncelet, V.S.7
End, D.W.8
-
2
-
-
4243157453
-
-
(b) Andresen, B. M.; Couturier, M.; Cronin, B.; D'Occhio, M.; Ewing, M. D.; Guinn, M.; Hawkins, J. M.; Jasys, V. J.; LaGreca, S. D.; Lyssikatos, J. P.; Moraski, G.; Ng, K.; Raggon, J. W.; Stewart, A. M.; Tickner, D. L.; Tucker, J. L.; Urban, F. J.; Vazquez, E.; Wei, L. Org. Process Res. Dev. 2004, 8, 643.
-
(2004)
Org. Process Res. Dev
, vol.8
, pp. 643
-
-
Andresen, B.M.1
Couturier, M.2
Cronin, B.3
D'Occhio, M.4
Ewing, M.D.5
Guinn, M.6
Hawkins, J.M.7
Jasys, V.J.8
LaGreca, S.D.9
Lyssikatos, J.P.10
Moraski, G.11
Ng, K.12
Raggon, J.W.13
Stewart, A.M.14
Tickner, D.L.15
Tucker, J.L.16
Urban, F.J.17
Vazquez, E.18
Wei, L.19
-
3
-
-
44849085438
-
-
For recent reports, see: a
-
For recent reports, see: (a) Cheng, P.; Zhang, Q.; Ma, Y.-B.; Jiang, Z.-Y.; Zhang, X.-M.; Zhang, F.-X.; Chen, J.-J. Bioorg. Med. Chem. Lett. 2008, 18, 3787.
-
(2008)
Bioorg. Med. Chem. Lett
, vol.18
, pp. 3787
-
-
Cheng, P.1
Zhang, Q.2
Ma, Y.-B.3
Jiang, Z.-Y.4
Zhang, X.-M.5
Zhang, F.-X.6
Chen, J.-J.7
-
4
-
-
57349159315
-
-
(b) Capell, B. C.; Olive, M.; Erdos, M. R.; Cao, K.; Faddah, D. A.; Tavarez, U. L.; Conneely, K. N.; Qu, X.; San, H.; Ganesh, S. K.; Chen, X.; Avallone, H.; Kolodgie, F. D.; Virmani, R.; Nabel, E. G.; Collins, F. S. Proc. Natl. Acad. sci. U. S. A. 2008, 105, 15902.
-
(2008)
Proc. Natl. Acad. sci. U. S. A
, vol.105
, pp. 15902
-
-
Capell, B.C.1
Olive, M.2
Erdos, M.R.3
Cao, K.4
Faddah, D.A.5
Tavarez, U.L.6
Conneely, K.N.7
Qu, X.8
San, H.9
Ganesh, S.K.10
Chen, X.11
Avallone, H.12
Kolodgie, F.D.13
Virmani, R.14
Nabel, E.G.15
Collins, F.S.16
-
5
-
-
40849102934
-
-
(c) Wall, M. J.; Chen, J.; Meegalla, S.; Ballentine, S. K.; Wilson, K. J.; DesJarlais, R. L.; Schubert, C; Chaikin, M. A.; Crysler, C.; Petrounia, I. P.; Donatelli, R. R.; Yurkow, E. J.; Boczon, L.; Mazzulla, M.; Player, M. R.; Patch, R. J.; Manthey, C. L.; Molloy, C; Tomczuk, B.; Illig, C. R. Bioorg. Med. Chem. Lett. 2008, 18, 2097.
-
(2008)
Bioorg. Med. Chem. Lett
, vol.18
, pp. 2097
-
-
Wall, M.J.1
Chen, J.2
Meegalla, S.3
Ballentine, S.K.4
Wilson, K.J.5
DesJarlais, R.L.6
Schubert, C.7
Chaikin, M.A.8
Crysler, C.9
Petrounia, I.P.10
Donatelli, R.R.11
Yurkow, E.J.12
Boczon, L.13
Mazzulla, M.14
Player, M.R.15
Patch, R.J.16
Manthey, C.L.17
Molloy, C.18
Tomczuk, B.19
Illig, C.R.20
more..
-
6
-
-
0037784031
-
-
(a) Hewawasam, P.; Fan, W.; Ding, M.; Flint, K.; Cook, D.; Goggings, G. D.; Myers, R. A.; Gribkoff, V. K.; Boissard, C. G.; Dworetzky, S. I.; Starret, J. E.; Lodge, N. J. J. Med. Chem. 2003, 46, 2819.
-
(2003)
J. Med. Chem
, vol.46
, pp. 2819
-
-
Hewawasam, P.1
Fan, W.2
Ding, M.3
Flint, K.4
Cook, D.5
Goggings, G.D.6
Myers, R.A.7
Gribkoff, V.K.8
Boissard, C.G.9
Dworetzky, S.I.10
Starret, J.E.11
Lodge, N.J.12
-
7
-
-
2342557311
-
-
(b) Cappelli, A.; Mohr, G. la P.; Gallelli, A.; Rizzo, M.; Anzini, M.; Vomero, S.; Mennuni, L.; Ferrari, F.; Makovec, F.; Menziani, M C.; Benedetti, P. G De B.; Giorgi, G. J. Med. Chem. 2004, 47, 2574.
-
(2004)
J. Med. Chem
, vol.47
, pp. 2574
-
-
Cappelli, A.1
Mohr, G.L.P.2
Gallelli, A.3
Rizzo, M.4
Anzini, M.5
Vomero, S.6
Mennuni, L.7
Ferrari, F.8
Makovec, F.9
Menziani, M.C.10
Benedetti, P.G.D.B.11
Giorgi, G.12
-
9
-
-
0000325598
-
-
(b) Bracken, A.; Pocker, A.; Raistrick, H. Biochem. J. 1954, 57, 587.
-
(1954)
Biochem. J
, vol.57
, pp. 587
-
-
Bracken, A.1
Pocker, A.2
Raistrick, H.3
-
14
-
-
0031922766
-
-
Heguy, A.; Cai, P.; Meyn, P.; Houck, D.; Russo, S.; Mchitsch, R.; Pearce, C.; Katz, B.; Bringmann, G.; Feineis, D.; Taylor, D. L.; Tyms, A. S. Antiviral Chem. Chemother. 1998, 9, 149.
-
(1998)
Antiviral Chem. Chemother
, vol.9
, pp. 149
-
-
Heguy, A.1
Cai, P.2
Meyn, P.3
Houck, D.4
Russo, S.5
Mchitsch, R.6
Pearce, C.7
Katz, B.8
Bringmann, G.9
Feineis, D.10
Taylor, D.L.11
Tyms, A.S.12
-
15
-
-
34548558652
-
-
Ribeiro, N.; Tabaka, H.; Peluso, J.; Fetzer, L.; Nebigil, C.; Dumont, S.; Muller, C. D.; Désaubry, L. Bioorg. Med. Chem. Lett. 2007, 17, 5523.
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 5523
-
-
Ribeiro, N.1
Tabaka, H.2
Peluso, J.3
Fetzer, L.4
Nebigil, C.5
Dumont, S.6
Muller, C.D.7
Désaubry, L.8
-
16
-
-
64349112226
-
-
U. S. Patent 5, 892, 045
-
Sit, S.-Y.; Meanwell, N. A. U. S. Patent 5, 892, 045, 1999.
-
(1999)
-
-
Sit, S.-Y.1
Meanwell, N.A.2
-
20
-
-
0013459959
-
-
(b) Martin, P. K.; Rapoport, H.; Smith, H. W.; Wong, J. L. J. Org. Chem. 1969, 34, 1359.
-
(1969)
J. Org. Chem
, vol.34
, pp. 1359
-
-
Martin, P.K.1
Rapoport, H.2
Smith, H.W.3
Wong, J.L.4
-
21
-
-
0003151465
-
The Friedlander Synthesis of Quinolines
-
For a review, see:, Dauben, W. C, Ed, J. Wiley and Sons: New York
-
(a) For a review, see: Cheng, C.-C.; Yan, S.-J. The Friedlander Synthesis of Quinolines. In Organic Reactions; Dauben, W. C., Ed.; J. Wiley and Sons: New York, 1982; Vol. 28, p 37.
-
(1982)
Organic Reactions
, vol.28
, pp. 37
-
-
Cheng, C.-C.1
Yan, S.-J.2
-
22
-
-
0015786853
-
-
(b) Terada, A.; Yabe, Y.; Miyadera, T.; Tachikawa, R. Chem. Pharm. Bull. 1973, 21, 807.
-
(1973)
Chem. Pharm. Bull
, vol.21
, pp. 807
-
-
Terada, A.1
Yabe, Y.2
Miyadera, T.3
Tachikawa, R.4
-
23
-
-
45249118399
-
-
Arshad, N.; Hashim, J.; Kappe, C. O. J. Org. Chem. 2008, 73, 4755.
-
(2008)
J. Org. Chem
, vol.73
, pp. 4755
-
-
Arshad, N.1
Hashim, J.2
Kappe, C.O.3
-
25
-
-
64349095096
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-
Cyanoacetanilides (7a-f) were prepared by reacting cyanoacetic acid with the corresponding aniline up to a 20-g scale (77-96% yields). For experimental details, see the Supporting Information.
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Cyanoacetanilides (7a-f) were prepared by reacting cyanoacetic acid with the corresponding aniline up to a 20-g scale (77-96% yields). For experimental details, see the Supporting Information.
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26
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64349089347
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All spectral data were in full accord with those reported in the literature; see the Supporting Information
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All spectral data were in full accord with those reported in the literature; see the Supporting Information.
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27
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0001586671
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-
For reviews of Friedel-Crafts and related reactions, see: a, Trost, B. M, Fleming I, Eds, Pergamon: Oxford, Chapter 1.8
-
For reviews of Friedel-Crafts and related reactions, see: (a) Olah, G. A.; Krishnamurti, R.; Prakash, G. S. S. In Comprehensive Organic Synthesis; Trost, B. M., Fleming I., Eds.; Pergamon: Oxford, 1991; Vol. 3, Chapter 1.8.
-
(1991)
Comprehensive Organic Synthesis
, vol.3
-
-
Olah, G.A.1
Krishnamurti, R.2
Prakash, G.S.S.3
-
30
-
-
84952096388
-
-
For recent examples, see: For a review of epoxide-arene cyclizations, see: a
-
For a review of epoxide-arene cyclizations, see: (a) Taylor, S. K. Org. Prep. Proced. Int. 1992, 24, 245. For recent examples, see:
-
(1992)
Org. Prep. Proced. Int
, vol.24
, pp. 245
-
-
Taylor, S.K.1
-
31
-
-
33644554790
-
-
(b) Islas-González, G.; Benet-Buchholz, J.; Maestro, M. A.; Riera, A.; Pericàs, M. A. J. Org. Chem. 2006, 71, 1537.
-
(2006)
J. Org. Chem
, vol.71
, pp. 1537
-
-
Islas-González, G.1
Benet-Buchholz, J.2
Maestro, M.A.3
Riera, A.4
Pericàs, M.A.5
-
33
-
-
0037128514
-
-
(d) Nagumo, S.; Miyoshi, I.; Akita, H.; Kawahara, N. Tetrahedron Lett. 2002, 43, 2223.
-
(2002)
Tetrahedron Lett
, vol.43
, pp. 2223
-
-
Nagumo, S.1
Miyoshi, I.2
Akita, H.3
Kawahara, N.4
-
34
-
-
34147122576
-
-
(e) Yang, L.; Deng, G.; Wang, D.-X.; Huang, Z.-T.; Zhu, J.-P.; Wang, M.-X. Org. Lett. 2007, 9, 1387.
-
(2007)
Org. Lett
, vol.9
, pp. 1387
-
-
Yang, L.1
Deng, G.2
Wang, D.-X.3
Huang, Z.-T.4
Zhu, J.-P.5
Wang, M.-X.6
-
36
-
-
58049196944
-
-
(g) Marcos, R.; Rodríguez-Escrich, C.; Herrerías, C. I.; Pericàs, M. A. J. Am. Chem. Soc. 2008, 130, 16838.
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 16838
-
-
Marcos, R.1
Rodríguez-Escrich, C.2
Herrerías, C.I.3
Pericàs, M.A.4
-
37
-
-
56949097429
-
-
For a recent example of related cyclizations, see
-
(h) Nagumo, S.; Ishii, Y.; Sato, G.; Mizukami, M.; Imai, M.; Kawahara, N.; Akita, H. Tetrahedron Lett. 2009, 50, 26. For a recent example of related cyclizations, see:
-
(2009)
Tetrahedron Lett
, vol.50
, pp. 26
-
-
Nagumo, S.1
Ishii, Y.2
Sato, G.3
Mizukami, M.4
Imai, M.5
Kawahara, N.6
Akita, H.7
-
39
-
-
64349109768
-
-
2 was used as the oxidant instead of t-BuOOH, we observed partial hydrolysis of the CN group of 9aa.
-
2 was used as the oxidant instead of t-BuOOH, we observed partial hydrolysis of the CN group of 9aa.
-
-
-
-
40
-
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64349113690
-
-
Note that a tertiary anilide must be used to ensure a smooth annulation reaction. This is because the reaction of the secondary anilide (R1 = H) does not proceed at all, most probably due to conformational reasons; see: (a) Pederson, B. F.; Pederson, B. Tetrahedron Lett. 1965, 2995.
-
Note that a tertiary anilide must be used to ensure a smooth annulation reaction. This is because the reaction of the secondary anilide (R1 = H) does not proceed at all, most probably due to conformational reasons; see: (a) Pederson, B. F.; Pederson, B. Tetrahedron Lett. 1965, 2995.
-
-
-
-
41
-
-
0012412028
-
-
(b) Nanjan, M. J.; Kannappan, V.; Ganesan, R. IndianJ. Chem. 1979, 18B, 461.
-
(1979)
IndianJ. Chem
, vol.18 B
, pp. 461
-
-
Nanjan, M.J.1
Kannappan, V.2
Ganesan, R.3
-
42
-
-
0024460631
-
-
(c) Itai, A.; Toriumi, Y.; Tomioka, N.; Kagechika, H.; Azumaya, I.; Shudo, K. Tetrahedron Lett. 1989, 30, 6177.
-
(1989)
Tetrahedron Lett
, vol.30
, pp. 6177
-
-
Itai, A.1
Toriumi, Y.2
Tomioka, N.3
Kagechika, H.4
Azumaya, I.5
Shudo, K.6
-
43
-
-
0036857568
-
-
The term telescoping has been used before to describe sequential multistep/multipot processes with shortened or omitted isolation procedures for the involved intermediates; see, e.g.: Dale, D. J.; Draper, J.; Dunn, P. J.; Hughes, M. L.; Hussain, F.; Levett, P. C.; Ward, G. B.; Wood, A. S. Org. Process Res. Dev. 2002, 6, 767.
-
The term "telescoping" has been used before to describe sequential multistep/multipot processes with shortened or omitted isolation procedures for the involved intermediates; see, e.g.: Dale, D. J.; Draper, J.; Dunn, P. J.; Hughes, M. L.; Hussain, F.; Levett, P. C.; Ward, G. B.; Wood, A. S. Org. Process Res. Dev. 2002, 6, 767.
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-
-
-
44
-
-
33847247279
-
-
For recent examples of other reactions fully exploiting the CN groups, see: a
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For recent examples of other reactions fully exploiting the CN groups, see: (a) Kobayashi, Y.; Kamisaki, H.; Takeda, H.; Yasui, Y.; Yanada, R.; Takemoto, Y. Tetrahedron 2007, 63, 2978.
-
(2007)
Tetrahedron
, vol.63
, pp. 2978
-
-
Kobayashi, Y.1
Kamisaki, H.2
Takeda, H.3
Yasui, Y.4
Yanada, R.5
Takemoto, Y.6
-
45
-
-
67650329691
-
-
(b) Nakao, Y.; Ebata, S.; Yada, A.; Hiyama, T.; Ikawa, M.; Ogoshi, S. J. Am. Chem. Soc. 2008, 130, 12874.
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 12874
-
-
Nakao, Y.1
Ebata, S.2
Yada, A.3
Hiyama, T.4
Ikawa, M.5
Ogoshi, S.6
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