4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 2819-2822

  Hewawasam, Piyasena ^a   Fan, Wenhong ^a   Ding, Min ^a   Flint, Kim ^a   Cook, Deborah ^a   Goggins, Gregory D ^a   Myers, Robert A ^a   Gribkoff, Valentin K ^a   Boissard, Christopher G ^a   Dworetzky, Steven I ^a   Starrett Jr , John E ^a   Lodge, Nicholas J ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOQUINOLIN 2 ONE DERIVATIVE; 3 HYDROXYQUINOLIN 2 ONE DERIVATIVE; CROMAKALIM; IBERIOTOXIN; NICORANDIL; PHOSPHODIESTERASE INHIBITOR; PINACIDIL; POTASSIUM CHANNEL AFFECTING AGENT; QUINOLIN 2 ONE DERIVATIVE; QUINOLONE DERIVATIVE; SILDENAFIL; UNCLASSIFIED DRUG;

ARTICLE; CARDIOTOXICITY; CORPUS CAVERNOSUM; DRUG ACTIVITY; ELECTROPHYSIOLOGY; ERECTILE DYSFUNCTION; HUMAN; IN VITRO STUDY; NEUROPROTECTION; RETINA DISEASE; SMOOTH MUSCLE; XENOPUS LAEVIS;

ANIMALS; BLOOD PRESSURE; ELECTRIC STIMULATION; IMPOTENCE; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PENILE ERECTION; PENIS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PRESSURE; QUINOLONES; RABBITS; RATS; RATS, INBRED F344; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037784031     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030005h     Document Type: Article

References (24)

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