Synthetic approach to malibatol A

Organic Letters

Volumn 5, Issue 8, 2003, Pages 1191-1192

  Kraus, George A ^a   Kim, Ikyon ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BENZOFURAN DERIVATIVE; MALIBATOL A; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; STILBENE DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ANTI-HIV AGENTS; BENZOFURANS; STILBENES;

EID: 0037587497     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol027574o     Document Type: Article

References (12)

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2. Dai, J. R.; Hallock, Y. F.; Cardellina, J. H.; Boyd, M. J. Nat. Prod. 1998, 61, 351-3. Balanocarpol was also isolated: Diyasena, M. N. C.; Sotheeswaran, S.; Surendrakumar, S.; Balasubramanian, S.; Bokel, M.; Kraus, W. J. Chem. Soc., Perkin Trans. 1 1985, 1807-9.
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12. In compound 8, the two-dimensional NOESY spectrum showed a strong interaction between the two methine hydrogens. The benzylic alcohol methine proton showed a NOE interaction only with the adjacent methine. If the stereochemistry were reversed, molecular models indicate that there would almost certainly be a strong NOE interaction with the hydrogen on C-5 of the benzofuran.